Cell atlas - H1FX - The Human Protein Atlas

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H1FX

TISSUE

CELL

PATHOLOGY

CELL ATLAS RNA EXPRESSION HUMAN CELLS

GENE/PROTEIN

Antibody validation

Dictionary
	Nucleoli
	Nucleus

Human cell
	Nucleoli
	Nucleoplasm

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GENERAL INFORMATION
Gene name	H1FX
Gene description	H1 histone family, member X
Protein class	Plasma proteins Predicted intracellular proteins
Predicted localization	Intracellular
Number of transcripts	1
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HUMAN PROTEIN ATLAS INFORMATION
Summary	Localized to the nucleus & nucleoli.
RNA cell category	Expressed in all
Protein evidence	Evidence at protein level
Main location	Localized to the Nucleus (validated), Nucleoli (validated)

DATA RELIABILITY
Reliability score	Validated based on 2 antibodies. CAB012235 , HPA040099
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ASSAYS

RNA expression

Human cells

RNA EXPRESSION OVERVIEW
RNA cell line category: Expressed in all Organ Origin Category Expression Alphabetical Cell lines sorted after organ of phenotypic resemblance. Cell lines sorted after biological source for establishment. Cell lines sorted after the cell line category according to Cellosaurus. Cell lines sorted on descending RNA expression. Cell lines sorted alphabetically.

HUMAN CELLS

Summary

Localized to the nucleus & nucleoli.

Main location

Nucleus (validated), Nucleoli (validated)


	Toggle channels	Low High G1 S G2 M N/A

Antibody	Cell line	Location
CAB012235	A-431	Nucleus
CAB012235	A-431	Nucleoli
CAB012235	U-2 OS	Nucleus
CAB012235	U-2 OS	Nucleoli
CAB012235	U-251 MG	Nucleus
CAB012235	U-251 MG	Nucleoli
HPA040099	A-431	Nucleus
HPA040099	A-431	Nucleoli
HPA040099	U-2 OS	Nucleus
HPA040099	U-2 OS	Nucleoli
HPA040099	U-251 MG	No staining

GENE INFORMATION
Gene name	H1FX (HGNC Symbol)
Synonyms	H1X, MGC15959, MGC8350
Description	H1 histone family, member X (HGNC Symbol)
Entrez gene summary	Histones are basic nuclear proteins that are responsible for the nucleosome structure of the chromosomal fiber in eukaryotes. Nucleosomes consist of approximately 146 bp of DNA wrapped around a histone octamer composed of pairs of each of the four core histones (H2A, H2B, H3, and H4). The chromatin fiber is further compacted through the interaction of a linker histone, H1, with the DNA between the nucleosomes to form higher order chromatin structures. This gene encodes a replication-independent histone that is a member of the histone H1 family. [provided by RefSeq, Oct 2015]
Chromosome	3
Cytoband	q21.3
Chromosome location (bp)	129314771 - 129316277
Protein evidence	Evidence at protein level (all genes)
Ensembl	ENSG00000184897 (version 83.38)
Entrez gene	8971
UniProt	Q92522 (UniProt - Evidence at protein level)
neXtProt	NX_Q92522
Antibodypedia	H1FX antibodies

PROTEIN BROWSER

H1FX-001

PROTEIN INFORMATION
Splice variant	UniProt	Protein class	Gene ontology	Length & mass	Signal peptide (predicted)	Transmembrane regions (predicted)
H1FX-001 ENSP00000329662 ENST00000333762	Q92522 [Direct mapping] Histone H1x Show all	Predicted intracellular proteins Plasma proteins Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0000786 [nucleosome] GO:0003677 [DNA binding] GO:0005515 [protein binding] GO:0005634 [nucleus] GO:0005730 [nucleolus] GO:0006334 [nucleosome assembly] GO:0044822 [poly(A) RNA binding] Show all	213 aa 22.5 kDa	No	0

Contact

contact@proteinatlas.org

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.