Expression of H1FX in cancer - Summary - The Human Protein Atlas

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H1FX

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TISSUE

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CELL

PATHOLOGY

PATHOLOGY ATLAS

GENE/PROTEIN

Antibody validation

Dictionary


Level of antibody staining/expression
	High Medium Low Not detected

GENERAL INFORMATION
Gene name	H1FX
Gene description	H1 histone family, member X
Protein class	Plasma proteins Predicted intracellular proteins
Predicted localization	Intracellular
Number of transcripts	1
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HUMAN PROTEIN ATLAS INFORMATION

RNA category

TCGA (cancer tissue):	Expressed in all
HPA (cell line):	Expressed in all
HPA (normal tissue):	Tissue enriched (bone marrow)

Protein evidence

Evidence at protein level

Protein expression
normal tissue

General nuclear expression.

ANTIBODY IHC RELIABILITY
Data reliability description	Antibody staining mainly not consistent with RNA expression data.
Reliability score	Supported based on 2 antibodies. HPA040099 , CAB012235
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PROGNOSTIC SUMMARY
Gene product is not prognostic.
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RNA EXPRESSION OVERVIEW
TCGA dataset RNA cancer category: Expressed in all

PROTEIN EXPRESSION

Colorectal cancer

Prostate cancer

STAINING SUMMARY

HPA040099	CAB012235

GENE INFORMATION
Gene name	H1FX (HGNC Symbol)
Synonyms	H1X, MGC15959, MGC8350
Description	H1 histone family, member X (HGNC Symbol)
Entrez gene summary	Histones are basic nuclear proteins that are responsible for the nucleosome structure of the chromosomal fiber in eukaryotes. Nucleosomes consist of approximately 146 bp of DNA wrapped around a histone octamer composed of pairs of each of the four core histones (H2A, H2B, H3, and H4). The chromatin fiber is further compacted through the interaction of a linker histone, H1, with the DNA between the nucleosomes to form higher order chromatin structures. This gene encodes a replication-independent histone that is a member of the histone H1 family. [provided by RefSeq, Oct 2015]
Chromosome	3
Cytoband	q21.3
Chromosome location (bp)	129314771 - 129316277
Protein evidence	Evidence at protein level (all genes)
Ensembl	ENSG00000184897 (version 83.38)
Entrez gene	8971
UniProt	Q92522 (UniProt - Evidence at protein level)
neXtProt	NX_Q92522
Antibodypedia	H1FX antibodies

PROTEIN BROWSER

H1FX-001

PROTEIN INFORMATION
Splice variant	UniProt	Protein class	Gene ontology	Length & mass	Signal peptide (predicted)	Transmembrane regions (predicted)
H1FX-001 ENSP00000329662 ENST00000333762	Q92522 [Direct mapping] Histone H1x Show all	Predicted intracellular proteins Plasma proteins Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0000786 [nucleosome] GO:0003677 [DNA binding] GO:0005515 [protein binding] GO:0005634 [nucleus] GO:0005730 [nucleolus] GO:0006334 [nucleosome assembly] GO:0044822 [poly(A) RNA binding] Show all	213 aa 22.5 kDa	No	0

Contact

contact@proteinatlas.org

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.