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WT1

GENERAL INFORMATION

Gene name

 WT1

Gene description

 Wilms tumor 1

Protein class

 Cancer-related genes
Disease related genes
Predicted intracellular proteins
Transcription factors

Predicted localization

 Intracellular

Number of transcripts

 8
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HUMAN PROTEIN ATLAS INFORMATION

RNA category
TCGA (cancer tissue):Tissue enriched (ovarian cancer)
HPA (cell line):Cell line enhanced (HEL, HMC-1, K-562, NB-4, THP-1)
HPA (normal tissue):Tissue enhanced (endometrium, fallopian tube, smooth muscle)

Protein evidence

 Evidence at protein level

Protein expression
normal tissue

 Nuclear expression in few tissues including fallopian tube, endometrium and testis.

ANTIBODY IHC RELIABILITY

Data reliability
description

 Antibody staining consistent with RNA expression data. External characterization data supports antibody staining.

Reliability score

 Supported based on 1 antibody.
CAB000327
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PROGNOSTIC SUMMARY
Gene product is not prognostic.
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RNA EXPRESSION OVERVIEW
TCGA dataset
RNA cancer category: Tissue enriched (ovarian cancer)

PROTEIN EXPRESSION
Colorectal cancer
Breast cancer
Prostate cancer
Lung cancer
Melanoma

STAINING SUMMARY
CAB000327

GENE INFORMATION

Gene name

 WT1 (HGNC Symbol)

Synonyms

 AWT1, GUD, WAGR, WIT-2

Description

 Wilms tumor 1 (HGNC Symbol)

Entrez gene summary

 This gene encodes a transcription factor that contains four zinc-finger motifs at the C-terminus and a proline/glutamine-rich DNA-binding domain at the N-terminus. It has an essential role in the normal development of the urogenital system, and it is mutated in a small subset of patients with Wilms tumor. This gene exhibits complex tissue-specific and polymorphic imprinting pattern, with biallelic, and monoallelic expression from the maternal and paternal alleles in different tissues. Multiple transcript variants have been described. In several variants, there is evidence for the use of a non-AUG (CUG) translation initiation codon upstream of, and in-frame with the first AUG. Authors of PMID:7926762 also provide evidence that WT1 mRNA undergoes RNA editing in human and rat, and that this process is tissue-restricted and developmentally regulated. [provided by RefSeq, Mar 2015]

Chromosome

 11

Cytoband

 p13

Chromosome location (bp)

 32387775 - 32435630

Protein evidence

 Evidence at protein level (all genes)

Ensembl

 ENSG00000184937 (version 83.38)

Entrez gene

 7490

UniProt

 P19544 (UniProt - Evidence at protein level)

neXtProt

 NX_P19544

Antibodypedia

 WT1 antibodies

PROTEIN BROWSER
WT1-001
WT1-002
WT1-003
WT1-004
WT1-006
WT1-007
WT1-008
WT1-009

PROTEIN INFORMATION

Splice variant

UniProt

Protein class

Gene ontology

Length & mass

Signal peptide
(predicted)

Transmembrane regions
(predicted)
WT1-001
ENSP00000331327
ENST00000332351
J3KNN9 [Direct mapping]
Wilms tumor protein
Show all
Predicted intracellular proteins
Cancer-related genes
   Mutated cancer genes
   Mutational cancer driver genes
   COSMIC somatic mutations in cancer genes
   COSMIC Splicing Mutations
   COSMIC Somatic Mutations
   COSMIC Nonsense Mutations
   COSMIC Missense Mutations
   COSMIC Large Deletions
   COSMIC Germline Mutations
   COSMIC Frameshift Mutations
Protein evidence (Kim et al 2014)
Show all
GO:0001570 [vasculogenesis]
GO:0001656 [metanephros development]
GO:0001823 [mesonephros development]
GO:0003690 [double-stranded DNA binding]
GO:0003700 [transcription factor activity, sequence-specific DNA binding]
GO:0003723 [RNA binding]
GO:0005634 [nucleus]
GO:0005654 [nucleoplasm]
GO:0005737 [cytoplasm]
GO:0006355 [regulation of transcription, DNA-templated]
GO:0006357 [regulation of transcription from RNA polymerase II promoter]
GO:0006915 [apoptotic process]
GO:0007281 [germ cell development]
GO:0007283 [spermatogenesis]
GO:0007338 [single fertilization]
GO:0008584 [male gonad development]
GO:0009888 [tissue development]
GO:0010468 [regulation of gene expression]
GO:0030317 [sperm motility]
GO:0043010 [camera-type eye development]
GO:0043565 [sequence-specific DNA binding]
GO:0045944 [positive regulation of transcription from RNA polymerase II promoter]
GO:0046872 [metal ion binding]
GO:0060009 [Sertoli cell development]
GO:0072112 [glomerular visceral epithelial cell differentiation]
GO:0072520 [seminiferous tubule development]
GO:1900212 [negative regulation of mesenchymal cell apoptotic process involved in metanephros development]
Show all
 517 aa
56.3 kDa 		No 0
WT1-002
ENSP00000368370
ENST00000379079
P19544 [Direct mapping]
Wilms tumor protein
Show all
Predicted intracellular proteins
Transcription factors
   Zinc-coordinating DNA-binding domains
Cancer-related genes
   Candidate cancer biomarkers
   Mutated cancer genes
   Mutational cancer driver genes
   COSMIC somatic mutations in cancer genes
   COSMIC Splicing Mutations
   COSMIC Somatic Mutations
   COSMIC Nonsense Mutations
   COSMIC Missense Mutations
   COSMIC Large Deletions
   COSMIC Germline Mutations
   COSMIC Frameshift Mutations
Disease related genes
Protein evidence (Kim et al 2014)
Show all
GO:0000122 [negative regulation of transcription from RNA polymerase II promoter]
GO:0001077 [transcriptional activator activity, RNA polymerase II core promoter proximal region sequence-specific binding]
GO:0001570 [vasculogenesis]
GO:0001657 [ureteric bud development]
GO:0001658 [branching involved in ureteric bud morphogenesis]
GO:0001822 [kidney development]
GO:0003156 [regulation of organ formation]
GO:0003700 [transcription factor activity, sequence-specific DNA binding]
GO:0003723 [RNA binding]
GO:0005515 [protein binding]
GO:0005634 [nucleus]
GO:0005654 [nucleoplasm]
GO:0005730 [nucleolus]
GO:0005737 [cytoplasm]
GO:0006355 [regulation of transcription, DNA-templated]
GO:0006357 [regulation of transcription from RNA polymerase II promoter]
GO:0006366 [transcription from RNA polymerase II promoter]
GO:0007281 [germ cell development]
GO:0007356 [thorax and anterior abdomen determination]
GO:0007507 [heart development]
GO:0007530 [sex determination]
GO:0008270 [zinc ion binding]
GO:0008285 [negative regulation of cell proliferation]
GO:0008380 [RNA splicing]
GO:0008406 [gonad development]
GO:0008584 [male gonad development]
GO:0009888 [tissue development]
GO:0016607 [nuclear speck]
GO:0017148 [negative regulation of translation]
GO:0030308 [negative regulation of cell growth]
GO:0030325 [adrenal gland development]
GO:0030539 [male genitalia development]
GO:0030855 [epithelial cell differentiation]
GO:0032835 [glomerulus development]
GO:0032836 [glomerular basement membrane development]
GO:0035802 [adrenal cortex formation]
GO:0043010 [camera-type eye development]
GO:0043065 [positive regulation of apoptotic process]
GO:0043066 [negative regulation of apoptotic process]
GO:0043565 [sequence-specific DNA binding]
GO:0044212 [transcription regulatory region DNA binding]
GO:0045892 [negative regulation of transcription, DNA-templated]
GO:0045893 [positive regulation of transcription, DNA-templated]
GO:0045944 [positive regulation of transcription from RNA polymerase II promoter]
GO:0046872 [metal ion binding]
GO:0060231 [mesenchymal to epithelial transition]
GO:0060421 [positive regulation of heart growth]
GO:0060539 [diaphragm development]
GO:0060923 [cardiac muscle cell fate commitment]
GO:0061032 [visceral serous pericardium development]
GO:0070742 [C2H2 zinc finger domain binding]
GO:0071320 [cellular response to cAMP]
GO:0071371 [cellular response to gonadotropin stimulus]
GO:0072075 [metanephric mesenchyme development]
GO:0072112 [glomerular visceral epithelial cell differentiation]
GO:0072166 [posterior mesonephric tubule development]
GO:0072207 [metanephric epithelium development]
GO:0072284 [metanephric S-shaped body morphogenesis]
GO:0072302 [negative regulation of metanephric glomerular mesangial cell proliferation]
GO:2000020 [positive regulation of male gonad development]
GO:2000195 [negative regulation of female gonad development]
GO:2001076 [positive regulation of metanephric ureteric bud development]
Show all
 302 aa
34.4 kDa 		No 0
WT1-003
ENSP00000435307
ENST00000530998
P19544 [Direct mapping]
Wilms tumor protein
Show all
Predicted intracellular proteins
Transcription factors
   Zinc-coordinating DNA-binding domains
Cancer-related genes
   Candidate cancer biomarkers
   Mutated cancer genes
   Mutational cancer driver genes
   COSMIC somatic mutations in cancer genes
   COSMIC Splicing Mutations
   COSMIC Somatic Mutations
   COSMIC Nonsense Mutations
   COSMIC Missense Mutations
   COSMIC Large Deletions
   COSMIC Germline Mutations
   COSMIC Frameshift Mutations
Disease related genes
Protein evidence (Kim et al 2014)
Show all
GO:0000122 [negative regulation of transcription from RNA polymerase II promoter]
GO:0001077 [transcriptional activator activity, RNA polymerase II core promoter proximal region sequence-specific binding]
GO:0001570 [vasculogenesis]
GO:0001657 [ureteric bud development]
GO:0001658 [branching involved in ureteric bud morphogenesis]
GO:0001822 [kidney development]
GO:0003156 [regulation of organ formation]
GO:0003700 [transcription factor activity, sequence-specific DNA binding]
GO:0003723 [RNA binding]
GO:0005515 [protein binding]
GO:0005634 [nucleus]
GO:0005654 [nucleoplasm]
GO:0005730 [nucleolus]
GO:0005737 [cytoplasm]
GO:0006355 [regulation of transcription, DNA-templated]
GO:0006357 [regulation of transcription from RNA polymerase II promoter]
GO:0006366 [transcription from RNA polymerase II promoter]
GO:0007281 [germ cell development]
GO:0007356 [thorax and anterior abdomen determination]
GO:0007507 [heart development]
GO:0007530 [sex determination]
GO:0008270 [zinc ion binding]
GO:0008285 [negative regulation of cell proliferation]
GO:0008380 [RNA splicing]
GO:0008406 [gonad development]
GO:0008584 [male gonad development]
GO:0009888 [tissue development]
GO:0016607 [nuclear speck]
GO:0017148 [negative regulation of translation]
GO:0030308 [negative regulation of cell growth]
GO:0030325 [adrenal gland development]
GO:0030539 [male genitalia development]
GO:0030855 [epithelial cell differentiation]
GO:0032835 [glomerulus development]
GO:0032836 [glomerular basement membrane development]
GO:0035802 [adrenal cortex formation]
GO:0043010 [camera-type eye development]
GO:0043065 [positive regulation of apoptotic process]
GO:0043066 [negative regulation of apoptotic process]
GO:0043565 [sequence-specific DNA binding]
GO:0044212 [transcription regulatory region DNA binding]
GO:0045892 [negative regulation of transcription, DNA-templated]
GO:0045893 [positive regulation of transcription, DNA-templated]
GO:0045944 [positive regulation of transcription from RNA polymerase II promoter]
GO:0046872 [metal ion binding]
GO:0060231 [mesenchymal to epithelial transition]
GO:0060421 [positive regulation of heart growth]
GO:0060539 [diaphragm development]
GO:0060923 [cardiac muscle cell fate commitment]
GO:0061032 [visceral serous pericardium development]
GO:0070742 [C2H2 zinc finger domain binding]
GO:0071320 [cellular response to cAMP]
GO:0071371 [cellular response to gonadotropin stimulus]
GO:0072075 [metanephric mesenchyme development]
GO:0072112 [glomerular visceral epithelial cell differentiation]
GO:0072166 [posterior mesonephric tubule development]
GO:0072207 [metanephric epithelium development]
GO:0072284 [metanephric S-shaped body morphogenesis]
GO:0072302 [negative regulation of metanephric glomerular mesangial cell proliferation]
GO:2000020 [positive regulation of male gonad development]
GO:2000195 [negative regulation of female gonad development]
GO:2001076 [positive regulation of metanephric ureteric bud development]
Show all
 288 aa
33.1 kDa 		No 0
WT1-004
ENSP00000415516
ENST00000452863
A0A0A0MT54 [Direct mapping]
Wilms tumor protein
Show all
Predicted intracellular proteins
Cancer-related genes
   Mutated cancer genes
   Mutational cancer driver genes
   COSMIC somatic mutations in cancer genes
   COSMIC Splicing Mutations
   COSMIC Somatic Mutations
   COSMIC Nonsense Mutations
   COSMIC Missense Mutations
   COSMIC Large Deletions
   COSMIC Germline Mutations
   COSMIC Frameshift Mutations
Protein evidence (Kim et al 2014)
Show all
GO:0003676 [nucleic acid binding]
GO:0003700 [transcription factor activity, sequence-specific DNA binding]
GO:0005634 [nucleus]
GO:0005737 [cytoplasm]
GO:0006355 [regulation of transcription, DNA-templated]
GO:0046872 [metal ion binding]
GO:0072112 [glomerular visceral epithelial cell differentiation]
Show all
 497 aa
54.3 kDa 		No 0
WT1-006
ENSP00000435351
ENST00000527775
E9PKS2 [Direct mapping]
Wilms tumor protein
Show all
Predicted intracellular proteins
Cancer-related genes
   Mutated cancer genes
   Mutational cancer driver genes
   COSMIC somatic mutations in cancer genes
   COSMIC Splicing Mutations
   COSMIC Somatic Mutations
   COSMIC Nonsense Mutations
   COSMIC Missense Mutations
   COSMIC Large Deletions
   COSMIC Germline Mutations
   COSMIC Frameshift Mutations
Show all
GO:0003700 [transcription factor activity, sequence-specific DNA binding]
GO:0005634 [nucleus]
GO:0005737 [cytoplasm]
GO:0006355 [regulation of transcription, DNA-templated]
GO:0072112 [glomerular visceral epithelial cell differentiation]
Show all
 131 aa
14.2 kDa 		No 0
WT1-007
ENSP00000436292
ENST00000526685
E9PPW3 [Direct mapping]
Wilms tumor protein
Show all
Predicted intracellular proteins
Cancer-related genes
   Mutated cancer genes
   Mutational cancer driver genes
   COSMIC somatic mutations in cancer genes
   COSMIC Splicing Mutations
   COSMIC Somatic Mutations
   COSMIC Nonsense Mutations
   COSMIC Missense Mutations
   COSMIC Large Deletions
   COSMIC Germline Mutations
   COSMIC Frameshift Mutations
Show all
GO:0003676 [nucleic acid binding]
GO:0003700 [transcription factor activity, sequence-specific DNA binding]
GO:0005737 [cytoplasm]
GO:0006355 [regulation of transcription, DNA-templated]
GO:0046872 [metal ion binding]
GO:0072112 [glomerular visceral epithelial cell differentiation]
Show all
 25 aa
3 kDa 		No 0
WT1-008
ENSP00000435624
ENST00000527882
H0YED9 [Direct mapping]
Wilms tumor protein
Show all
Predicted intracellular proteins
Cancer-related genes
   Mutated cancer genes
   Mutational cancer driver genes
   COSMIC somatic mutations in cancer genes
   COSMIC Splicing Mutations
   COSMIC Somatic Mutations
   COSMIC Nonsense Mutations
   COSMIC Missense Mutations
   COSMIC Large Deletions
   COSMIC Germline Mutations
   COSMIC Frameshift Mutations
Show all
GO:0003676 [nucleic acid binding]
GO:0003700 [transcription factor activity, sequence-specific DNA binding]
GO:0005634 [nucleus]
GO:0005737 [cytoplasm]
GO:0006355 [regulation of transcription, DNA-templated]
GO:0046872 [metal ion binding]
GO:0072112 [glomerular visceral epithelial cell differentiation]
Show all
 178 aa
20.1 kDa 		No 0
WT1-009
ENSP00000413452
ENST00000448076
H0Y7K5 [Direct mapping]
Wilms tumor protein
Show all
Predicted intracellular proteins
Cancer-related genes
   Mutated cancer genes
   Mutational cancer driver genes
   COSMIC somatic mutations in cancer genes
   COSMIC Splicing Mutations
   COSMIC Somatic Mutations
   COSMIC Nonsense Mutations
   COSMIC Missense Mutations
   COSMIC Large Deletions
   COSMIC Germline Mutations
   COSMIC Frameshift Mutations
Protein evidence (Kim et al 2014)
Show all
GO:0003676 [nucleic acid binding]
GO:0003700 [transcription factor activity, sequence-specific DNA binding]
GO:0005634 [nucleus]
GO:0005654 [nucleoplasm]
GO:0005737 [cytoplasm]
GO:0006355 [regulation of transcription, DNA-templated]
GO:0046872 [metal ion binding]
GO:0072112 [glomerular visceral epithelial cell differentiation]
Show all
 514 aa
55.9 kDa 		No 0

Contact

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.