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AP3M1

GENERAL INFORMATION

Gene name

 AP3M1

Gene description

 Adaptor-related protein complex 3, mu 1 subunit

Protein class

 Predicted intracellular proteins

Predicted localization

 Intracellular

Number of transcripts

 2
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HUMAN PROTEIN ATLAS INFORMATION

RNA category
TCGA (cancer tissue):Expressed in all
HPA (cell line):Expressed in all
HPA (normal tissue):Expressed in all

Protein evidence

 Evidence at protein level

Protein expression
normal tissue

 Cytoplasmic expression in several different tissue types.

ANTIBODY IHC RELIABILITY

Data reliability
description

 Caution, targets protein from more than one gene. Pending external verification.

Reliability score

 Uncertain based on 2 antibodies.
HPA045591 , HPA048380
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PROGNOSTIC SUMMARY
Gene product is not prognostic.
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RNA EXPRESSION OVERVIEW
TCGA dataset
RNA cancer category: Expressed in all

PROTEIN EXPRESSION
Colorectal cancer
Breast cancer
Prostate cancer
Lung cancer

STAINING SUMMARY
HPA045591
HPA048380

GENE INFORMATION

Gene name

 AP3M1

Synonyms

Description

 Adaptor-related protein complex 3, mu 1 subunit (HGNC Symbol)

Entrez gene summary

 The protein encoded by this gene is the medium subunit of AP-3, which is an adaptor-related protein complex associated with the Golgi region as well as more peripheral intracellular structures. AP-3 facilitates the budding of vesicles from the Golgi membrane and may be directly involved in protein sorting to the endosomal/lysosomal system. AP-3 is a heterotetrameric protein complex composed of two large subunits (delta and beta3), a medium subunit (mu3), and a small subunit (sigma 3). Mutations in one of the large subunits of AP-3 have been associated with the Hermansky-Pudlak syndrome, a genetic disorder characterized by defective lysosome-related organelles. Alternatively spliced transcript variants encoding the same protein have been observed. [provided by RefSeq, Jul 2008]

Chromosome

 10

Cytoband

 q22.2

Chromosome location (bp)

 74120255 - 74151063

Protein evidence

 Evidence at protein level (all genes)

Ensembl

 ENSG00000185009 (version 83.38)

Entrez gene

 26985

UniProt

 Q9Y2T2 (UniProt - Evidence at protein level)

neXtProt

 NX_Q9Y2T2

Antibodypedia

 AP3M1 antibodies

PROTEIN BROWSER
AP3M1-001
AP3M1-002

PROTEIN INFORMATION

Splice variant

UniProt

Protein class

Gene ontology

Length & mass

Signal peptide
(predicted)

Transmembrane regions
(predicted)
AP3M1-001
ENSP00000347408
ENST00000355264
Q9Y2T2 [Direct mapping]
AP-3 complex subunit mu-1
A0A024QZR5 [Target identity:100%; Query identity:100%]
Adaptor-related protein complex 3, mu 1 subunit, isoform CRA_a
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Predicted intracellular proteins
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
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GO:0005515 [protein binding]
GO:0005764 [lysosome]
GO:0005765 [lysosomal membrane]
GO:0005794 [Golgi apparatus]
GO:0006622 [protein targeting to lysosome]
GO:0006810 [transport]
GO:0006886 [intracellular protein transport]
GO:0008089 [anterograde axon cargo transport]
GO:0016192 [vesicle-mediated transport]
GO:0017137 [Rab GTPase binding]
GO:0030131 [clathrin adaptor complex]
GO:0030659 [cytoplasmic vesicle membrane]
GO:0048490 [anterograde synaptic vesicle transport]
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 418 aa
46.9 kDa 		No 0
AP3M1-002
ENSP00000361831
ENST00000372745
Q9Y2T2 [Direct mapping]
AP-3 complex subunit mu-1
A0A024QZR5 [Target identity:100%; Query identity:100%]
Adaptor-related protein complex 3, mu 1 subunit, isoform CRA_a
Show all
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0005515 [protein binding]
GO:0005764 [lysosome]
GO:0005765 [lysosomal membrane]
GO:0005794 [Golgi apparatus]
GO:0006622 [protein targeting to lysosome]
GO:0006810 [transport]
GO:0006886 [intracellular protein transport]
GO:0008089 [anterograde axon cargo transport]
GO:0016192 [vesicle-mediated transport]
GO:0017137 [Rab GTPase binding]
GO:0030131 [clathrin adaptor complex]
GO:0030659 [cytoplasmic vesicle membrane]
GO:0048490 [anterograde synaptic vesicle transport]
Show all
 418 aa
46.9 kDa 		No 0

Contact

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.