Expression of CA13 in cancer - Summary - The Human Protein Atlas

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CA13

TISSUE

CELL

PATHOLOGY

PATHOLOGY ATLAS

GENE/PROTEIN

Antibody validation

Dictionary


Level of antibody staining/expression
	High Medium Low Not detected

GENERAL INFORMATION
Gene name	CA13
Gene description	Carbonic anhydrase XIII
Protein class	Enzymes Predicted intracellular proteins
Predicted localization	Intracellular
Number of transcripts	1
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HUMAN PROTEIN ATLAS INFORMATION

RNA category

TCGA (cancer tissue):	Expressed in all
HPA (cell line):	Cell line enhanced (HEL)
HPA (normal tissue):	Mixed

Protein evidence

Evidence at protein level

Protein expression
normal tissue

General cytoplasmic expression, most abundant in the intestinal tract.

ANTIBODY IHC RELIABILITY
Data reliability description	Antibody staining mainly consistent with RNA expression data. Pending external verification.
Reliability score	Approved based on 2 antibodies. HPA024689 , CAB025567
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PROGNOSTIC SUMMARY
Prognostic marker in renal cancer (favourable).
Renal cancer p<0.001 Show all

RNA EXPRESSION OVERVIEW
TCGA dataset RNA cancer category: Expressed in all

PROTEIN EXPRESSION

Colorectal cancer

Prostate cancer

STAINING SUMMARY

HPA024689	CAB025567

GENE INFORMATION
Gene name	CA13 (HGNC Symbol)
Synonyms	CAXIII, FLJ37995, MGC59868
Description	Carbonic anhydrase XIII (HGNC Symbol)
Entrez gene summary	Carbonic anhydrases (CAs) are a family of zinc metalloenzymes. For background information on the CA family, see MIM 114800.[supplied by OMIM, Mar 2008]
Chromosome	8
Cytoband	q21.2
Chromosome location (bp)	85220587 - 85284073
Protein evidence	Evidence at protein level (all genes)
Ensembl	ENSG00000185015 (version 83.38)
Entrez gene	377677
UniProt	Q8N1Q1 (UniProt - Evidence at protein level)
neXtProt	NX_Q8N1Q1
Antibodypedia	CA13 antibodies

PROTEIN BROWSER

CA13-001

PROTEIN INFORMATION
Splice variant	UniProt	Protein class	Gene ontology	Length & mass	Signal peptide (predicted)	Transmembrane regions (predicted)
CA13-001 ENSP00000318912 ENST00000321764	Q8N1Q1 [Direct mapping] Carbonic anhydrase 13 Show all	Enzymes ENZYME proteins Lyases Predicted intracellular proteins Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0004089 [carbonate dehydratase activity] GO:0005829 [cytosol] GO:0006730 [one-carbon metabolic process] GO:0008270 [zinc ion binding] GO:0015701 [bicarbonate transport] GO:0043209 [myelin sheath] GO:0043231 [intracellular membrane-bounded organelle] GO:0044281 [small molecule metabolic process] Show all	262 aa 29.4 kDa	No	0

Contact

contact@proteinatlas.org

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.