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The product of this gene is a heat-shock transcription factor. Transcription of heat-shock genes is rapidly induced after temperature stress. Hsp90, by itself and/or associated with multichaperone complexes, is a major repressor of this gene. [provided by RefSeq, Jul 2008]
Q00613 [Direct mapping] Heat shock factor protein 1
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Predicted intracellular proteins Plasma proteins Transcription factors Helix-turn-helix domains Cancer-related genes Candidate cancer biomarkers Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014)
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GO:0000122 [negative regulation of transcription from RNA polymerase II promoter] GO:0000978 [RNA polymerase II core promoter proximal region sequence-specific DNA binding] GO:0001078 [transcriptional repressor activity, RNA polymerase II core promoter proximal region sequence-specific binding] GO:0001162 [RNA polymerase II intronic transcription regulatory region sequence-specific DNA binding] GO:0001701 [in utero embryonic development] GO:0001892 [embryonic placenta development] GO:0003677 [DNA binding] GO:0003682 [chromatin binding] GO:0003700 [transcription factor activity, sequence-specific DNA binding] GO:0005515 [protein binding] GO:0005634 [nucleus] GO:0005654 [nucleoplasm] GO:0005737 [cytoplasm] GO:0005829 [cytosol] GO:0006355 [regulation of transcription, DNA-templated] GO:0006468 [protein phosphorylation] GO:0006952 [defense response] GO:0007143 [female meiotic division] GO:0007283 [spermatogenesis] GO:0008285 [negative regulation of cell proliferation] GO:0009299 [mRNA transcription] GO:0009408 [response to heat] GO:0032496 [response to lipopolysaccharide] GO:0032720 [negative regulation of tumor necrosis factor production] GO:0034605 [cellular response to heat] GO:0040018 [positive regulation of multicellular organism growth] GO:0043234 [protein complex] GO:0043565 [sequence-specific DNA binding] GO:0045120 [pronucleus] GO:0045944 [positive regulation of transcription from RNA polymerase II promoter] GO:0060136 [embryonic process involved in female pregnancy] GO:1900034 [regulation of cellular response to heat]