Expression of TNFAIP2 in cancer - Summary

GENERAL INFORMATION
Gene name	TNFAIP2
Gene description	Tumor necrosis factor, alpha-induced protein 2
Protein class	Cancer-related genes Plasma proteins Predicted intracellular proteins Transporters
Predicted localization	Intracellular
Number of transcripts	5
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HUMAN PROTEIN ATLAS INFORMATION

RNA category

TCGA (cancer tissue):	Expressed in all
HPA (cell line):	Cell line enhanced (RT4)
HPA (normal tissue):	Expressed in all

Protein evidence

Evidence at protein level

Protein expression
normal tissue

Cytoplasmic and nuclear expression in several tissues, most abundant in immune cells and urinary bladder.

ANTIBODY IHC RELIABILITY
Data reliability description	Antibody staining mainly consistent with RNA expression data.
Reliability score	Supported based on 1 antibody. CAB004598
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PROGNOSTIC SUMMARY
Prognostic marker in stomach cancer (favourable), urothelial cancer (favourable) and renal cancer (unfavourable).
Stomach cancer p<0.001 Urothelial cancer p<0.001 Renal cancer p<0.001 Show all

RNA EXPRESSION OVERVIEW
TCGA dataset RNA cancer category: Expressed in all

PROTEIN EXPRESSION

STAINING SUMMARY

CAB004598

GENE INFORMATION
Gene name	TNFAIP2 (HGNC Symbol)
Synonyms	B94, EXOC3L3
Description	Tumor necrosis factor, alpha-induced protein 2 (HGNC Symbol)
Entrez gene summary	This gene was identified as a gene whose expression can be induced by the tumor necrosis factor alpha (TNF) in umbilical vein endothelial cells. The expression of this gene was shown to be induced by retinoic acid in a cell line expressing a oncogenic version of the retinoic acid receptor alpha fusion protein, which suggested that this gene may be a retinoic acid target gene in acute promyelocytic leukemia. [provided by RefSeq, Jul 2008]
Chromosome	14
Cytoband	q32.32
Chromosome location (bp)	103123442 - 103137439
Protein evidence	Evidence at protein level (all genes)
Ensembl	ENSG00000185215 (version 83.38)
Entrez gene	7127
UniProt	Q03169 (UniProt - Evidence at transcript level)
neXtProt	NX_Q03169
Antibodypedia	TNFAIP2 antibodies

PROTEIN BROWSER

TNFAIP2-001	TNFAIP2-004	TNFAIP2-005	TNFAIP2-006	TNFAIP2-201

PROTEIN INFORMATION
Splice variant	UniProt	Protein class	Gene ontology	Length & mass	Signal peptide (predicted)	Transmembrane regions (predicted)
TNFAIP2-001 ENSP00000452634 ENST00000560869	Q03169 [Direct mapping] Tumor necrosis factor alpha-induced protein 2 Show all	Transporters Transporter channels and pores Predicted intracellular proteins Plasma proteins Cancer-related genes Candidate cancer biomarkers Protein evidence (Ezkurdia et al 2014) Show all	GO:0000145 [exocyst] GO:0000149 [SNARE binding] GO:0001525 [angiogenesis] GO:0005615 [extracellular space] GO:0006887 [exocytosis] GO:0030154 [cell differentiation] GO:0051601 [exocyst localization] Show all	654 aa 72.7 kDa	No	0
TNFAIP2-004 ENSP00000453142 ENST00000560670	H0YLC0 [Direct mapping] Tumor necrosis factor alpha-induced protein 2 Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0000145 [exocyst] GO:0000149 [SNARE binding] GO:0006887 [exocytosis] GO:0051601 [exocyst localization] Show all	347 aa 39.1 kDa	No	0
TNFAIP2-005 ENSP00000452914 ENST00000559255	H0YKR7 [Direct mapping] Tumor necrosis factor alpha-induced protein 2 Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0000145 [exocyst] GO:0000149 [SNARE binding] GO:0006887 [exocytosis] GO:0051601 [exocyst localization] Show all	243 aa 27.2 kDa	No	0
TNFAIP2-006 ENSP00000453103 ENST00000558056	H0YL88 [Direct mapping] Tumor necrosis factor alpha-induced protein 2 Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0000145 [exocyst] GO:0000149 [SNARE binding] GO:0006887 [exocytosis] GO:0051601 [exocyst localization] Show all	39 aa 4.3 kDa	No	0
TNFAIP2-201 ENSP00000332326 ENST00000333007	Q03169 [Direct mapping] Tumor necrosis factor alpha-induced protein 2 Show all	Transporters Transporter channels and pores Predicted intracellular proteins Plasma proteins Cancer-related genes Candidate cancer biomarkers Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0000145 [exocyst] GO:0000149 [SNARE binding] GO:0001525 [angiogenesis] GO:0005615 [extracellular space] GO:0006887 [exocytosis] GO:0030154 [cell differentiation] GO:0051601 [exocyst localization] Show all	654 aa 72.7 kDa	No	0