Expression of MC2R in cancer - Summary - The Human Protein Atlas

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MC2R

TISSUE

CELL

PATHOLOGY

GENERAL INFORMATION
Gene name	MC2R
Gene description	Melanocortin 2 receptor (adrenocorticotropic hormone)
Protein class	Disease related genes FDA approved drug targets G-protein coupled receptors Predicted membrane proteins Transporters
Predicted localization	Membrane
Number of transcripts	2
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HUMAN PROTEIN ATLAS INFORMATION

RNA category

TCGA (cancer tissue):	Not detected
HPA (cell line):	Not detected
HPA (normal tissue):	Tissue enriched (adrenal gland)

Protein evidence

Evidence at protein level

ANTIBODY IHC RELIABILITY
Reliability score	Pending cancer tissue analysis.

PROGNOSTIC SUMMARY
Gene product is not prognostic.
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RNA EXPRESSION OVERVIEW
TCGA dataset RNA cancer category: Not detected

PROTEIN EXPRESSION
Pending cancer tissue analysis
STAINING SUMMARY

GENE INFORMATION
Gene name	MC2R (HGNC Symbol)
Synonyms	ACTHR
Description	Melanocortin 2 receptor (adrenocorticotropic hormone) (HGNC Symbol)
Entrez gene summary	MC2R encodes one member of the five-member G-protein associated melanocortin receptor family. Melanocortins (melanocyte-stimulating hormones and adrenocorticotropic hormone) are peptides derived from pro-opiomelanocortin (POMC). MC2R is selectively activated by adrenocorticotropic hormone, whereas the other four melanocortin receptors recognize a variety of melanocortin ligands. Mutations in MC2R can result in familial glucocorticoid deficiency. Alternate transcript variants have been found for this gene. [provided by RefSeq, May 2014]
Chromosome	18
Cytoband	p11.21
Chromosome location (bp)	13882044 - 13915707
Protein evidence	Evidence at protein level (all genes)
Ensembl	ENSG00000185231 (version 83.38)
Entrez gene	4158
UniProt	Q01718 (UniProt - Evidence at protein level)
neXtProt	NX_Q01718
Antibodypedia	MC2R antibodies

PROTEIN BROWSER

MC2R-001	MC2R-002

PROTEIN INFORMATION
Splice variant	UniProt	Protein class	Gene ontology	Length & mass	Signal peptide (predicted)	Transmembrane regions (predicted)
MC2R-001 ENSP00000333821 ENST00000327606	Q01718 [Direct mapping] Adrenocorticotropic hormone receptor Show all	Transporters G-protein coupled receptors GPCRs excl olfactory receptors Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins GPCRHMM predicted membrane proteins # TM segments-based 7TM proteins predicted by MDM Disease related genes FDA approved drug targets Biotech drugs Protein evidence (Kim et al 2014) Show all	GO:0001890 [placenta development] GO:0004930 [G-protein coupled receptor activity] GO:0004977 [melanocortin receptor activity] GO:0004978 [corticotropin receptor activity] GO:0005515 [protein binding] GO:0005737 [cytoplasm] GO:0005886 [plasma membrane] GO:0005887 [integral component of plasma membrane] GO:0007186 [G-protein coupled receptor signaling pathway] GO:0007187 [G-protein coupled receptor signaling pathway, coupled to cyclic nucleotide second messenger] GO:0007218 [neuropeptide signaling pathway] GO:0016021 [integral component of membrane] GO:0030819 [positive regulation of cAMP biosynthetic process] Show all	297 aa 33.9 kDa	No	7
MC2R-002 ENSP00000382718 ENST00000399821	R4GMM0 [Direct mapping] Adrenocorticotropic hormone receptor Show all	Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based 3TM proteins predicted by MDM Show all	GO:0004930 [G-protein coupled receptor activity] GO:0004978 [corticotropin receptor activity] GO:0007186 [G-protein coupled receptor signaling pathway] GO:0007218 [neuropeptide signaling pathway] GO:0016021 [integral component of membrane] Show all	123 aa 13.8 kDa	No	3

Contact

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The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.