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PRMT3

GENERAL INFORMATION

Gene name

 PRMT3

Gene description

 Protein arginine methyltransferase 3

Protein class

 Predicted intracellular proteins

Predicted localization

 Intracellular

Number of transcripts

 2
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HUMAN PROTEIN ATLAS INFORMATION

RNA tissue category
HPA:Expressed in all
GTEx:Expressed in all
FANTOM5:Expressed in all

Protein evidence

 Evidence at protein level

Protein expression

 Ubiquitous cytoplasmic expression.

DATA RELIABILITY

Data reliability
description

 Antibody staining mainly not consistent with RNA expression data. Pending external verification.

Reliability score

 Uncertain based on 2 antibodies.
HPA007832 , CAB022083
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RNA AND PROTEIN EXPRESSION SUMMARY
RNA expression (TPM) Protein expression (score)
Brain
Caudate
N/A
Endocrine tissues
Bone marrow & immune system
Muscle tissues
Lung
Bronchus
N/A
Liver & gallbladder
Pancreas
Gastrointestinal tract
Kidney & urinary bladder
Male tissues
Female tissues
Vagina
N/A
Adipose & soft tissue
Skin
Cerebral cortex

Lymph node

Liver

Colon

Kidney

Testis

PROTEIN EXPRESSION OVERVIEW
Organ
Expression
Alphabetical

RNA EXPRESSION OVERVIEW
HPA dataset
Organ
Expression
Alphabetical
RNA tissue category: Expressed in all
GTEx dataset
Organ
Expression
Alphabetical
RNA tissue category: Expressed in all
FANTOM5 dataset
Organ
Expression
Alphabetical
RNA tissue category: Expressed in all

GENE INFORMATION

Gene name

 PRMT3 (HGNC Symbol)

Synonyms

 HRMT1L3

Description

 Protein arginine methyltransferase 3 (HGNC Symbol)

Entrez gene summary

 This gene belongs to the protein arginine methyltransferase (PRMT) family. The encoded enzyme catalyzes the methylation of guanidino nitrogens of arginyl residues of proteins. The enzyme acts on 40S ribosomal protein S2 (rpS2), which is its major in-vivo substrate, and is involved in the proper maturation of the 80S ribosome. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Aug 2013]

Chromosome

 11

Cytoband

 p15.1

Chromosome location (bp)

 20387530 - 20509294

Protein evidence

 Evidence at protein level (all genes)

Ensembl

 ENSG00000185238 (version 83.38)

Entrez gene

 10196

UniProt

 O60678 (UniProt - Evidence at protein level)

neXtProt

 NX_O60678

Antibodypedia

 PRMT3 antibodies

PROTEIN BROWSER
PRMT3-001
PRMT3-003

PROTEIN INFORMATION

Splice variant

UniProt

Protein class

Gene ontology

Length & mass

Signal peptide
(predicted)

Transmembrane regions
(predicted)
PRMT3-001
ENSP00000331879
ENST00000331079
O60678 [Direct mapping]
Protein arginine N-methyltransferase 3
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   SPOCTOPUS predicted membrane proteins
Predicted intracellular proteins
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0005515 [protein binding]
GO:0005737 [cytoplasm]
GO:0005829 [cytosol]
GO:0005840 [ribosome]
GO:0006355 [regulation of transcription, DNA-templated]
GO:0006479 [protein methylation]
GO:0008168 [methyltransferase activity]
GO:0008469 [histone-arginine N-methyltransferase activity]
GO:0016274 [protein-arginine N-methyltransferase activity]
GO:0019919 [peptidyl-arginine methylation, to asymmetrical-dimethyl arginine]
GO:0031397 [negative regulation of protein ubiquitination]
GO:0034969 [histone arginine methylation]
GO:0035242 [protein-arginine omega-N asymmetric methyltransferase activity]
GO:0046872 [metal ion binding]
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 531 aa
59.9 kDa 		No 0
PRMT3-003
ENSP00000397766
ENST00000437750
A0A0A0MSN7 [Direct mapping]
Protein arginine N-methyltransferase 3
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   SPOCTOPUS predicted membrane proteins
   SPOCTOPUS predicted secreted proteins
Predicted intracellular proteins
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0005829 [cytosol]
GO:0006355 [regulation of transcription, DNA-templated]
GO:0006479 [protein methylation]
GO:0008168 [methyltransferase activity]
GO:0008469 [histone-arginine N-methyltransferase activity]
GO:0019919 [peptidyl-arginine methylation, to asymmetrical-dimethyl arginine]
GO:0034969 [histone arginine methylation]
GO:0035242 [protein-arginine omega-N asymmetric methyltransferase activity]
Show all
 469 aa
52.9 kDa 		No 0

Contact

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.