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KRT6B

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GENERAL INFORMATION

Gene name

 KRT6B

Gene description

 Keratin 6B, type II

Protein class

 Disease related genes
Plasma proteins
Predicted intracellular proteins

Predicted localization

 Intracellular

Number of transcripts

 1
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HUMAN PROTEIN ATLAS INFORMATION

Summary

 Localized to the intermediate filaments. Caution: Based on antibodies targeting proteins from multiple genes.

RNA cell category

 Cell line enhanced (hTCEpi, RPMI-8226, HaCaT)

Protein evidence

 Evidence at protein level

Main location

 Localized to the Intermediate filaments (approved)

Single-cell variation

 Single-cell variation in protein expression observed.

DATA RELIABILITY

Reliability score

 Approved based on 1 antibody.
HPA045697
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ASSAYS
RNA expression
Human cells

RNA EXPRESSION OVERVIEW
RNA cell line category: Cell line enhanced (hTCEpi, RPMI-8226, HaCaT)
Organ
Origin
Category
Expression
Alphabetical
Cell lines sorted after organ of phenotypic resemblance.

HUMAN CELLS

Summary

 Localized to the intermediate filaments. Caution: Based on antibodies targeting proteins from multiple genes.

Main location

 Intermediate filaments (approved)

 

 

 
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Low
High
G1
S
G2
M
N/A

Thumbnail

Antibody

Cell line

Location

Single-cell variation

Cell cycle dependent variation
HPA045697 HaCaT Intermediate filaments Intensity
HPA045697 SiHa No staining    
HPA045697 U-2 OS Intermediate filaments Intensity

GENE INFORMATION

Gene name

 KRT6B (HGNC Symbol)

Synonyms

 KRTL1

Description

 Keratin 6B, type II (HGNC Symbol)

Entrez gene summary

 The protein encoded by this gene is a member of the keratin gene family. The type II cytokeratins consist of basic or neutral proteins which are arranged in pairs of heterotypic keratin chains coexpressed during differentiation of simple and stratified epithelial tissues. As many as six of this type II cytokeratin (KRT6) have been identified; the multiplicity of the genes is attributed to successive gene duplication events. The genes are expressed with family members KRT16 and/or KRT17 in the filiform papillae of the tongue, the stratified epithelial lining of oral mucosa and esophagus, the outer root sheath of hair follicles, and the glandular epithelia. Mutations in these genes have been associated with pachyonychia congenita. The type II cytokeratins are clustered in a region of chromosome 12q12-q13. [provided by RefSeq, Jul 2008]

Chromosome

 12

Cytoband

 q13.13

Chromosome location (bp)

 52446651 - 52452126

Protein evidence

 Evidence at protein level (all genes)

Ensembl

 ENSG00000185479 (version 83.38)

Entrez gene

 3854

UniProt

 P04259 (UniProt - Evidence at protein level)

neXtProt

 NX_P04259

Antibodypedia

 KRT6B antibodies

PROTEIN BROWSER
KRT6B-001

PROTEIN INFORMATION

Splice variant

UniProt

Protein class

Gene ontology

Length & mass

Signal peptide
(predicted)

Transmembrane regions
(predicted)
KRT6B-001
ENSP00000252252
ENST00000252252
P04259 [Direct mapping]
Keratin, type II cytoskeletal 6B
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Predicted intracellular proteins
Plasma proteins
Disease related genes
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
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GO:0005198 [structural molecule activity]
GO:0005200 [structural constituent of cytoskeleton]
GO:0005515 [protein binding]
GO:0005882 [intermediate filament]
GO:0007398 [ectoderm development]
GO:0045095 [keratin filament]
GO:0070062 [extracellular exosome]
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 564 aa
60.1 kDa 		No 0

Contact

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.