Expression of KRT6B in cancer - Summary - The Human Protein Atlas

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KRT6B

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TISSUE

CELL

PATHOLOGY

PATHOLOGY ATLAS

GENE/PROTEIN

Antibody validation

Dictionary


Level of antibody staining/expression
	High Medium Low Not detected

GENERAL INFORMATION
Gene name	KRT6B
Gene description	Keratin 6B, type II
Protein class	Disease related genes Plasma proteins Predicted intracellular proteins
Predicted localization	Intracellular
Number of transcripts	1
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HUMAN PROTEIN ATLAS INFORMATION

RNA category

TCGA (cancer tissue):	Tissue enhanced (head and neck cancer)
HPA (cell line):	Cell line enhanced (HaCaT, hTCEpi, RPMI-8226)
HPA (normal tissue):	Tissue enriched (esophagus)

Protein evidence

Evidence at protein level

Protein expression
normal tissue

Distinct cytoplasmic expression in squamous and respiratory epithelia.

ANTIBODY IHC RELIABILITY
Data reliability description	Antibody staining consistent with RNA expression data. Caution, targets protein from more than one gene.
Reliability score	Supported based on 3 antibodies. HPA045697 , HPA061168 , CAB000130
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PROGNOSTIC SUMMARY
Prognostic marker in breast cancer (favourable) and urothelial cancer (unfavourable).
Breast cancer p<0.001 Urothelial cancer p<0.001 Show all

RNA EXPRESSION OVERVIEW
TCGA dataset RNA cancer category: Tissue enhanced (head and neck cancer)

PROTEIN EXPRESSION

Colorectal cancer

Prostate cancer

STAINING SUMMARY

HPA045697	HPA061168	CAB000130

GENE INFORMATION
Gene name	KRT6B (HGNC Symbol)
Synonyms	KRTL1
Description	Keratin 6B, type II (HGNC Symbol)
Entrez gene summary	The protein encoded by this gene is a member of the keratin gene family. The type II cytokeratins consist of basic or neutral proteins which are arranged in pairs of heterotypic keratin chains coexpressed during differentiation of simple and stratified epithelial tissues. As many as six of this type II cytokeratin (KRT6) have been identified; the multiplicity of the genes is attributed to successive gene duplication events. The genes are expressed with family members KRT16 and/or KRT17 in the filiform papillae of the tongue, the stratified epithelial lining of oral mucosa and esophagus, the outer root sheath of hair follicles, and the glandular epithelia. Mutations in these genes have been associated with pachyonychia congenita. The type II cytokeratins are clustered in a region of chromosome 12q12-q13. [provided by RefSeq, Jul 2008]
Chromosome	12
Cytoband	q13.13
Chromosome location (bp)	52446651 - 52452126
Protein evidence	Evidence at protein level (all genes)
Ensembl	ENSG00000185479 (version 83.38)
Entrez gene	3854
UniProt	P04259 (UniProt - Evidence at protein level)
neXtProt	NX_P04259
Antibodypedia	KRT6B antibodies

PROTEIN BROWSER

KRT6B-001

PROTEIN INFORMATION
Splice variant	UniProt	Protein class	Gene ontology	Length & mass	Signal peptide (predicted)	Transmembrane regions (predicted)
KRT6B-001 ENSP00000252252 ENST00000252252	P04259 [Direct mapping] Keratin, type II cytoskeletal 6B Show all	Predicted intracellular proteins Plasma proteins Disease related genes Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0005198 [structural molecule activity] GO:0005200 [structural constituent of cytoskeleton] GO:0005515 [protein binding] GO:0005882 [intermediate filament] GO:0007398 [ectoderm development] GO:0045095 [keratin filament] GO:0070062 [extracellular exosome] Show all	564 aa 60.1 kDa	No	0

Contact

contact@proteinatlas.org

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.