Cell atlas - ROR1 - The Human Protein Atlas

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ROR1

TISSUE

CELL

PATHOLOGY

CELL ATLAS RNA EXPRESSION HUMAN CELLS CELL CYCLE

GENE/PROTEIN

Antibody validation

Dictionary
	Cytokinetic bridge
	Microtubules

Human cell
	Microtubules

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GENERAL INFORMATION
Gene name	ROR1
Gene description	Receptor tyrosine kinase-like orphan receptor 1
Protein class	Enzymes Predicted membrane proteins Predicted secreted proteins
Predicted localization	Membrane,Secreted
Number of transcripts	3
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HUMAN PROTEIN ATLAS INFORMATION
Summary	Mainly localized to the microtubules. In addition localized to the cytokinetic bridge.
RNA cell category	Cell line enhanced (NTERA-2, ASC TERT1, CACO-2)
Protein evidence	Evidence at protein level
Main location	Localized to the Microtubules (uncertain)
Additional location	In addition localized to the Cytokinetic bridge (uncertain)
Single-cell variation	Single-cell variation in protein expression observed.
Cell cycle dependency	Cell cycle dependent expression determined by biological definition

DATA RELIABILITY
Reliability score	Uncertain based on 1 antibody. HPA057016
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ASSAYS

RNA EXPRESSION OVERVIEW
RNA cell line category: Cell line enhanced (NTERA-2, ASC TERT1, CACO-2) Organ Origin Category Expression Alphabetical Cell lines sorted after organ of phenotypic resemblance. Cell lines sorted after biological source for establishment. Cell lines sorted after the cell line category according to Cellosaurus. Cell lines sorted on descending RNA expression. Cell lines sorted alphabetically.

HUMAN CELLS

Summary

Mainly localized to the microtubules. In addition localized to the cytokinetic bridge.

Main location

Microtubules (uncertain)

Additional location

Cytokinetic bridge (uncertain)


	Toggle channels	Low High G1 S G2 M N/A

Thumbnail	Antibody	Cell line	Location	Single-cell variation	Cell cycle dependent variation
	HPA057016	A-431	Microtubules
	HPA057016	CACO-2	Microtubules
	HPA057016	CACO-2	Cytokinetic bridge	Intensity	Intensity
	HPA057016	U-2 OS	Microtubules

CELL CYCLE
Summary	Expression has cell cycle dependency according to biological definition
Intensity variation	Cytokinetic bridge

GENE INFORMATION
Gene name	ROR1 (HGNC Symbol)
Synonyms	NTRKR1
Description	Receptor tyrosine kinase-like orphan receptor 1 (HGNC Symbol)
Entrez gene summary	This gene encodes a receptor tyrosine kinase-like orphan receptor that modulates neurite growth in the central nervous system. The encoded protein is a glycosylated type I membrane protein that belongs to the ROR subfamily of cell surface receptors. It is a pseudokinase that lacks catalytic activity and may interact with the non-canonical Wnt signalling pathway. This gene is highly expressed during early embryonic development but expressed at very low levels in adult tissues. Increased expression of this gene is associated with B-cell chronic lymphocytic leukaemia. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Jun 2012]
Chromosome	1
Cytoband	p31.3
Chromosome location (bp)	63774022 - 64181498
Protein evidence	Evidence at protein level (all genes)
Ensembl	ENSG00000185483 (version 83.38)
Entrez gene	4919
UniProt	Q01973 (UniProt - Evidence at protein level)
neXtProt	NX_Q01973
Antibodypedia	ROR1 antibodies

PROTEIN BROWSER

ROR1-001	ROR1-002	ROR1-201

PROTEIN INFORMATION
Splice variant	UniProt	Protein class	Gene ontology	Length & mass	Signal peptide (predicted)	Transmembrane regions (predicted)
ROR1-001 ENSP00000360120 ENST00000371079	Q01973 [Direct mapping] Inactive tyrosine-protein kinase transmembrane receptor ROR1 Show all	Enzymes Kinases Tyr protein kinases Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based 1TM proteins predicted by MDM Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0004672 [protein kinase activity] GO:0004714 [transmembrane receptor protein tyrosine kinase activity] GO:0005515 [protein binding] GO:0005524 [ATP binding] GO:0005737 [cytoplasm] GO:0005886 [plasma membrane] GO:0005887 [integral component of plasma membrane] GO:0006468 [protein phosphorylation] GO:0007169 [transmembrane receptor protein tyrosine kinase signaling pathway] GO:0016055 [Wnt signaling pathway] GO:0017147 [Wnt-protein binding] GO:0018108 [peptidyl-tyrosine phosphorylation] GO:0043235 [receptor complex] Show all	937 aa 104.3 kDa	Yes	1
ROR1-002 ENSP00000360121 ENST00000371080	Q01973 [Direct mapping] Inactive tyrosine-protein kinase transmembrane receptor ROR1 Show all	Enzymes Kinases Tyr protein kinases Predicted secreted proteins Secreted proteins predicted by MDSEC SignalP predicted secreted proteins Phobius predicted secreted proteins SPOCTOPUS predicted secreted proteins Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0004714 [transmembrane receptor protein tyrosine kinase activity] GO:0005515 [protein binding] GO:0005524 [ATP binding] GO:0005737 [cytoplasm] GO:0005886 [plasma membrane] GO:0005887 [integral component of plasma membrane] GO:0007169 [transmembrane receptor protein tyrosine kinase signaling pathway] GO:0016055 [Wnt signaling pathway] GO:0017147 [Wnt-protein binding] GO:0018108 [peptidyl-tyrosine phosphorylation] GO:0043235 [receptor complex] Show all	393 aa 43.8 kDa	Yes	0
ROR1-201 ENSP00000441637 ENST00000545203	A0A0A0MTJ5 [Direct mapping] Tyrosine-protein kinase transmembrane receptor Show all	Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based 1TM proteins predicted by MDM Protein evidence (Ezkurdia et al 2014) Show all	GO:0004672 [protein kinase activity] GO:0004714 [transmembrane receptor protein tyrosine kinase activity] GO:0005515 [protein binding] GO:0005524 [ATP binding] GO:0006468 [protein phosphorylation] GO:0007169 [transmembrane receptor protein tyrosine kinase signaling pathway] GO:0016021 [integral component of membrane] GO:0018108 [peptidyl-tyrosine phosphorylation] Show all	882 aa 98.4 kDa	No	1

Contact

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The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.