Expression of MUC1 in cancer - Summary - The Human Protein Atlas

GENERAL INFORMATION
Gene name	MUC1
Gene description	Mucin 1, cell surface associated
Protein class	Cancer-related genes CD markers Disease related genes Predicted intracellular proteins Predicted membrane proteins Predicted secreted proteins
Predicted localization	Intracellular,Membrane,Secreted
Number of transcripts	23
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HUMAN PROTEIN ATLAS INFORMATION

RNA category

TCGA (cancer tissue):	Expressed in all
HPA (cell line):	Group enriched (CAPAN-2, RPTEC TERT1, T-47d)
HPA (normal tissue):	Tissue enhanced (lung, stomach)

Protein evidence

Evidence at protein level

Protein expression
normal tissue

Cytoplasmic and membranous expression in a majority of tissues.

ANTIBODY IHC RELIABILITY
Data reliability description	Antibody staining mainly consistent with RNA expression data. Presumed off target binding observed and disregarded. Caution, Splice and/or transcript discrepancy exists.
Reliability score	Supported based on 5 antibodies. HPA004179 , HPA007235 , HPA008855 , CAB000036 , CAB001986
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PROGNOSTIC SUMMARY
Prognostic marker in pancreatic cancer (unfavourable).
Pancreatic cancer p<0.001 Show all

RNA EXPRESSION OVERVIEW
TCGA dataset RNA cancer category: Expressed in all

PROTEIN EXPRESSION

STAINING SUMMARY

HPA004179	HPA007235	HPA008855	CAB000036	CAB001986

GENE INFORMATION
Gene name	MUC1 (HGNC Symbol)
Synonyms	ADMCKD, ADMCKD1, CD227, MCD, MCKD, MCKD1, PEM, PUM
Description	Mucin 1, cell surface associated (HGNC Symbol)
Entrez gene summary	This gene encodes a membrane-bound protein that is a member of the mucin family. Mucins are O-glycosylated proteins that play an essential role in forming protective mucous barriers on epithelial surfaces. These proteins also play a role in intracellular signaling. This protein is expressed on the apical surface of epithelial cells that line the mucosal surfaces of many different tissues including lung, breast stomach and pancreas. This protein is proteolytically cleaved into alpha and beta subunits that form a heterodimeric complex. The N-terminal alpha subunit functions in cell-adhesion and the C-terminal beta subunit is involved in cell signaling. Overexpression, aberrant intracellular localization, and changes in glycosylation of this protein have been associated with carcinomas. This gene is known to contain a highly polymorphic variable number tandem repeats (VNTR) domain. Alternate splicing results in multiple transcript variants.[provided by RefSeq, Feb 2011]
Chromosome	1
Cytoband	q22
Chromosome location (bp)	155185824 - 155192916
Protein evidence	Evidence at protein level (all genes)
Ensembl	ENSG00000185499 (version 83.38)
Entrez gene	4582
UniProt	P15941 (UniProt - Evidence at protein level)
neXtProt	NX_P15941
Antibodypedia	MUC1 antibodies

PROTEIN BROWSER

MUC1-001	MUC1-002	MUC1-003	MUC1-005	MUC1-006	MUC1-007	MUC1-008	MUC1-009	MUC1-012	MUC1-013	MUC1-014	MUC1-017	MUC1-018	MUC1-020	MUC1-201	MUC1-202	MUC1-203	MUC1-204	MUC1-205	MUC1-206	MUC1-207	MUC1-208	MUC1-209

PROTEIN INFORMATION
Splice variant	UniProt	Protein class	Gene ontology	Length & mass	Signal peptide (predicted)	Transmembrane regions (predicted)
MUC1-001 ENSP00000481231 ENST00000620103	A0A0C4DGW3 [Direct mapping] Mucin-1 Show all	Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based 1TM proteins predicted by MDM Cancer-related genes COSMIC somatic mutations in cancer genes COSMIC Somatic Mutations COSMIC Translocations Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0016021 [integral component of membrane] Show all	475 aa 49.2 kDa	Yes	1
MUC1-002 ENSP00000357377 ENST00000368392	P15941 [Direct mapping] Mucin-1 Mucin-1 subunit alpha Mucin-1 subunit beta Show all	CD markers Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based 1TM proteins predicted by MDM Cancer-related genes Candidate cancer biomarkers COSMIC somatic mutations in cancer genes COSMIC Somatic Mutations COSMIC Translocations Disease related genes Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0000790 [nuclear chromatin] GO:0000978 [RNA polymerase II core promoter proximal region sequence-specific DNA binding] GO:0002039 [p53 binding] GO:0003712 [transcription cofactor activity] GO:0005515 [protein binding] GO:0005615 [extracellular space] GO:0005796 [Golgi lumen] GO:0005887 [integral component of plasma membrane] GO:0006493 [protein O-linked glycosylation] GO:0006977 [DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest] GO:0006978 [DNA damage response, signal transduction by p53 class mediator resulting in transcription of p21 class mediator] GO:0010944 [negative regulation of transcription by competitive promoter binding] GO:0016266 [O-glycan processing] GO:0016324 [apical plasma membrane] GO:0031982 [vesicle] GO:0033629 [negative regulation of cell adhesion mediated by integrin] GO:0036003 [positive regulation of transcription from RNA polymerase II promoter in response to stress] GO:0043618 [regulation of transcription from RNA polymerase II promoter in response to stress] GO:0043687 [post-translational protein modification] GO:0044267 [cellular protein metabolic process] GO:0070062 [extracellular exosome] GO:0090240 [positive regulation of histone H4 acetylation] GO:1902166 [negative regulation of intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator] Show all	264 aa 28.4 kDa	Yes	1
MUC1-003 ENSP00000389098 ENST00000438413	B1AVQ7 [Direct mapping] Mucin-1 Show all	Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based 1TM proteins predicted by MDM Cancer-related genes COSMIC somatic mutations in cancer genes COSMIC Somatic Mutations COSMIC Translocations Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0016021 [integral component of membrane] Show all	229 aa 24.4 kDa	Yes	1
MUC1-005 ENSP00000357374 ENST00000368389	P15941 [Direct mapping] Mucin-1 Mucin-1 subunit alpha Mucin-1 subunit beta Show all	CD markers THUMBUP predicted membrane proteins Predicted secreted proteins Secreted proteins predicted by MDSEC SignalP predicted secreted proteins Phobius predicted secreted proteins SPOCTOPUS predicted secreted proteins Cancer-related genes Candidate cancer biomarkers COSMIC somatic mutations in cancer genes COSMIC Somatic Mutations COSMIC Translocations Disease related genes Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0000790 [nuclear chromatin] GO:0000978 [RNA polymerase II core promoter proximal region sequence-specific DNA binding] GO:0002039 [p53 binding] GO:0003712 [transcription cofactor activity] GO:0005515 [protein binding] GO:0005615 [extracellular space] GO:0005796 [Golgi lumen] GO:0005887 [integral component of plasma membrane] GO:0006493 [protein O-linked glycosylation] GO:0006977 [DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest] GO:0006978 [DNA damage response, signal transduction by p53 class mediator resulting in transcription of p21 class mediator] GO:0010944 [negative regulation of transcription by competitive promoter binding] GO:0016266 [O-glycan processing] GO:0016324 [apical plasma membrane] GO:0031982 [vesicle] GO:0033629 [negative regulation of cell adhesion mediated by integrin] GO:0036003 [positive regulation of transcription from RNA polymerase II promoter in response to stress] GO:0043618 [regulation of transcription from RNA polymerase II promoter in response to stress] GO:0043687 [post-translational protein modification] GO:0044267 [cellular protein metabolic process] GO:0070062 [extracellular exosome] GO:0090240 [positive regulation of histone H4 acetylation] GO:1902166 [negative regulation of intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator] Show all	168 aa 18.3 kDa	Yes	0
MUC1-006 ENSP00000357381 ENST00000368396	P15941 [Direct mapping] Mucin-1 Mucin-1 subunit alpha Mucin-1 subunit beta Show all	CD markers MEMSAT3 predicted membrane proteins Predicted secreted proteins Secreted proteins predicted by MDSEC SignalP predicted secreted proteins Phobius predicted secreted proteins SPOCTOPUS predicted secreted proteins Cancer-related genes Candidate cancer biomarkers COSMIC somatic mutations in cancer genes COSMIC Somatic Mutations COSMIC Translocations Disease related genes Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0000790 [nuclear chromatin] GO:0000978 [RNA polymerase II core promoter proximal region sequence-specific DNA binding] GO:0002039 [p53 binding] GO:0003712 [transcription cofactor activity] GO:0005515 [protein binding] GO:0005615 [extracellular space] GO:0005796 [Golgi lumen] GO:0005887 [integral component of plasma membrane] GO:0006493 [protein O-linked glycosylation] GO:0006977 [DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest] GO:0006978 [DNA damage response, signal transduction by p53 class mediator resulting in transcription of p21 class mediator] GO:0010944 [negative regulation of transcription by competitive promoter binding] GO:0016266 [O-glycan processing] GO:0016324 [apical plasma membrane] GO:0031982 [vesicle] GO:0033629 [negative regulation of cell adhesion mediated by integrin] GO:0036003 [positive regulation of transcription from RNA polymerase II promoter in response to stress] GO:0043618 [regulation of transcription from RNA polymerase II promoter in response to stress] GO:0043687 [post-translational protein modification] GO:0044267 [cellular protein metabolic process] GO:0070062 [extracellular exosome] GO:0090240 [positive regulation of histone H4 acetylation] GO:1902166 [negative regulation of intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator] Show all	159 aa 17.1 kDa	Yes	0
MUC1-007 ENSP00000338983 ENST00000337604	P15941 [Direct mapping] Mucin-1 Mucin-1 subunit alpha Mucin-1 subunit beta Show all	CD markers Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based 1TM proteins predicted by MDM Cancer-related genes Candidate cancer biomarkers COSMIC somatic mutations in cancer genes COSMIC Somatic Mutations COSMIC Translocations Disease related genes Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0000790 [nuclear chromatin] GO:0000978 [RNA polymerase II core promoter proximal region sequence-specific DNA binding] GO:0002039 [p53 binding] GO:0003712 [transcription cofactor activity] GO:0005515 [protein binding] GO:0005615 [extracellular space] GO:0005796 [Golgi lumen] GO:0005887 [integral component of plasma membrane] GO:0006493 [protein O-linked glycosylation] GO:0006977 [DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest] GO:0006978 [DNA damage response, signal transduction by p53 class mediator resulting in transcription of p21 class mediator] GO:0010944 [negative regulation of transcription by competitive promoter binding] GO:0016266 [O-glycan processing] GO:0016324 [apical plasma membrane] GO:0031982 [vesicle] GO:0033629 [negative regulation of cell adhesion mediated by integrin] GO:0036003 [positive regulation of transcription from RNA polymerase II promoter in response to stress] GO:0043618 [regulation of transcription from RNA polymerase II promoter in response to stress] GO:0043687 [post-translational protein modification] GO:0044267 [cellular protein metabolic process] GO:0070062 [extracellular exosome] GO:0090240 [positive regulation of histone H4 acetylation] GO:1902166 [negative regulation of intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator] Show all	273 aa 29.6 kDa	Yes	1
MUC1-008 ENSP00000339690 ENST00000343256	P15941 [Direct mapping] Mucin-1 Mucin-1 subunit alpha Mucin-1 subunit beta Show all	CD markers Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based 1TM proteins predicted by MDM Cancer-related genes Candidate cancer biomarkers COSMIC somatic mutations in cancer genes COSMIC Somatic Mutations COSMIC Translocations Disease related genes Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0000790 [nuclear chromatin] GO:0000978 [RNA polymerase II core promoter proximal region sequence-specific DNA binding] GO:0002039 [p53 binding] GO:0003712 [transcription cofactor activity] GO:0005515 [protein binding] GO:0005615 [extracellular space] GO:0005796 [Golgi lumen] GO:0005887 [integral component of plasma membrane] GO:0006493 [protein O-linked glycosylation] GO:0006977 [DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest] GO:0006978 [DNA damage response, signal transduction by p53 class mediator resulting in transcription of p21 class mediator] GO:0010944 [negative regulation of transcription by competitive promoter binding] GO:0016266 [O-glycan processing] GO:0016324 [apical plasma membrane] GO:0031982 [vesicle] GO:0033629 [negative regulation of cell adhesion mediated by integrin] GO:0036003 [positive regulation of transcription from RNA polymerase II promoter in response to stress] GO:0043618 [regulation of transcription from RNA polymerase II promoter in response to stress] GO:0043687 [post-translational protein modification] GO:0044267 [cellular protein metabolic process] GO:0070062 [extracellular exosome] GO:0090240 [positive regulation of histone H4 acetylation] GO:1902166 [negative regulation of intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator] Show all	203 aa 21.6 kDa	Yes	1
MUC1-009 ENSP00000342814 ENST00000342482	P15941 [Direct mapping] Mucin-1 Mucin-1 subunit alpha Mucin-1 subunit beta Show all	CD markers Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based 1TM proteins predicted by MDM Cancer-related genes Candidate cancer biomarkers COSMIC somatic mutations in cancer genes COSMIC Somatic Mutations COSMIC Translocations Disease related genes Protein evidence (Ezkurdia et al 2014) Show all	GO:0000790 [nuclear chromatin] GO:0000978 [RNA polymerase II core promoter proximal region sequence-specific DNA binding] GO:0002039 [p53 binding] GO:0003712 [transcription cofactor activity] GO:0005515 [protein binding] GO:0005615 [extracellular space] GO:0005796 [Golgi lumen] GO:0005887 [integral component of plasma membrane] GO:0006493 [protein O-linked glycosylation] GO:0006977 [DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest] GO:0006978 [DNA damage response, signal transduction by p53 class mediator resulting in transcription of p21 class mediator] GO:0010944 [negative regulation of transcription by competitive promoter binding] GO:0016266 [O-glycan processing] GO:0016324 [apical plasma membrane] GO:0031982 [vesicle] GO:0033629 [negative regulation of cell adhesion mediated by integrin] GO:0036003 [positive regulation of transcription from RNA polymerase II promoter in response to stress] GO:0043618 [regulation of transcription from RNA polymerase II promoter in response to stress] GO:0043687 [post-translational protein modification] GO:0044267 [cellular protein metabolic process] GO:0070062 [extracellular exosome] GO:0090240 [positive regulation of histone H4 acetylation] GO:1902166 [negative regulation of intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator] Show all	166 aa 17.3 kDa	Yes	1
MUC1-012 ENSP00000484730 ENST00000471283	Q7Z536 [Direct mapping] Mucin short variant SV10; Mucin-1 Show all	THUMBUP predicted membrane proteins Predicted secreted proteins Secreted proteins predicted by MDSEC SignalP predicted secreted proteins Phobius predicted secreted proteins SPOCTOPUS predicted secreted proteins Cancer-related genes COSMIC somatic mutations in cancer genes COSMIC Somatic Mutations COSMIC Translocations Protein evidence (Ezkurdia et al 2014) Show all		149 aa 16.3 kDa	Yes	0
MUC1-013 ENSP00000357383 ENST00000368398	P15941 [Direct mapping] Mucin-1 Mucin-1 subunit alpha Mucin-1 subunit beta Show all	CD markers Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based 1TM proteins predicted by MDM Cancer-related genes Candidate cancer biomarkers COSMIC somatic mutations in cancer genes COSMIC Somatic Mutations COSMIC Translocations Disease related genes Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0000790 [nuclear chromatin] GO:0000978 [RNA polymerase II core promoter proximal region sequence-specific DNA binding] GO:0002039 [p53 binding] GO:0003712 [transcription cofactor activity] GO:0005515 [protein binding] GO:0005615 [extracellular space] GO:0005796 [Golgi lumen] GO:0005887 [integral component of plasma membrane] GO:0006493 [protein O-linked glycosylation] GO:0006977 [DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest] GO:0006978 [DNA damage response, signal transduction by p53 class mediator resulting in transcription of p21 class mediator] GO:0010944 [negative regulation of transcription by competitive promoter binding] GO:0016266 [O-glycan processing] GO:0016324 [apical plasma membrane] GO:0031982 [vesicle] GO:0033629 [negative regulation of cell adhesion mediated by integrin] GO:0036003 [positive regulation of transcription from RNA polymerase II promoter in response to stress] GO:0043618 [regulation of transcription from RNA polymerase II promoter in response to stress] GO:0043687 [post-translational protein modification] GO:0044267 [cellular protein metabolic process] GO:0070062 [extracellular exosome] GO:0090240 [positive regulation of histone H4 acetylation] GO:1902166 [negative regulation of intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator] Show all	230 aa 24.6 kDa	Yes	1
MUC1-014 ENSP00000357375 ENST00000368390	P15941 [Direct mapping] Mucin-1 Mucin-1 subunit alpha Mucin-1 subunit beta Show all	CD markers Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based 1TM proteins predicted by MDM Cancer-related genes Candidate cancer biomarkers COSMIC somatic mutations in cancer genes COSMIC Somatic Mutations COSMIC Translocations Disease related genes Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0000790 [nuclear chromatin] GO:0000978 [RNA polymerase II core promoter proximal region sequence-specific DNA binding] GO:0002039 [p53 binding] GO:0003712 [transcription cofactor activity] GO:0005515 [protein binding] GO:0005615 [extracellular space] GO:0005796 [Golgi lumen] GO:0005887 [integral component of plasma membrane] GO:0006493 [protein O-linked glycosylation] GO:0006977 [DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest] GO:0006978 [DNA damage response, signal transduction by p53 class mediator resulting in transcription of p21 class mediator] GO:0010944 [negative regulation of transcription by competitive promoter binding] GO:0016266 [O-glycan processing] GO:0016324 [apical plasma membrane] GO:0031982 [vesicle] GO:0033629 [negative regulation of cell adhesion mediated by integrin] GO:0036003 [positive regulation of transcription from RNA polymerase II promoter in response to stress] GO:0043618 [regulation of transcription from RNA polymerase II promoter in response to stress] GO:0043687 [post-translational protein modification] GO:0044267 [cellular protein metabolic process] GO:0070062 [extracellular exosome] GO:0090240 [positive regulation of histone H4 acetylation] GO:1902166 [negative regulation of intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator] Show all	255 aa 27.6 kDa	Yes	1
MUC1-017 ENSP00000479471 ENST00000462317	A0A087WVJ0 [Direct mapping] Mucin-1 Show all	Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based 1TM proteins predicted by MDM Cancer-related genes COSMIC somatic mutations in cancer genes COSMIC Somatic Mutations COSMIC Translocations Protein evidence (Ezkurdia et al 2014) Show all	GO:0016021 [integral component of membrane] Show all	228 aa 25.6 kDa	No	1
MUC1-018 ENSP00000478068 ENST00000485118	A0A087WTR1 [Direct mapping] Mucin-1 Show all	SPOCTOPUS predicted secreted proteins Predicted intracellular proteins Cancer-related genes COSMIC somatic mutations in cancer genes COSMIC Somatic Mutations COSMIC Translocations Protein evidence (Ezkurdia et al 2014) Show all		85 aa 8.9 kDa	No	0
MUC1-020 ENSP00000357378 ENST00000368393	P15941 [Direct mapping] Mucin-1 Mucin-1 subunit alpha Mucin-1 subunit beta Show all	CD markers THUMBUP predicted membrane proteins Predicted secreted proteins Secreted proteins predicted by MDSEC SignalP predicted secreted proteins Phobius predicted secreted proteins SPOCTOPUS predicted secreted proteins Cancer-related genes Candidate cancer biomarkers COSMIC somatic mutations in cancer genes COSMIC Somatic Mutations COSMIC Translocations Disease related genes Protein evidence (Ezkurdia et al 2014) Show all	GO:0000790 [nuclear chromatin] GO:0000978 [RNA polymerase II core promoter proximal region sequence-specific DNA binding] GO:0002039 [p53 binding] GO:0003712 [transcription cofactor activity] GO:0005515 [protein binding] GO:0005615 [extracellular space] GO:0005796 [Golgi lumen] GO:0005887 [integral component of plasma membrane] GO:0006493 [protein O-linked glycosylation] GO:0006977 [DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest] GO:0006978 [DNA damage response, signal transduction by p53 class mediator resulting in transcription of p21 class mediator] GO:0010944 [negative regulation of transcription by competitive promoter binding] GO:0016266 [O-glycan processing] GO:0016324 [apical plasma membrane] GO:0031982 [vesicle] GO:0033629 [negative regulation of cell adhesion mediated by integrin] GO:0036003 [positive regulation of transcription from RNA polymerase II promoter in response to stress] GO:0043618 [regulation of transcription from RNA polymerase II promoter in response to stress] GO:0043687 [post-translational protein modification] GO:0044267 [cellular protein metabolic process] GO:0070062 [extracellular exosome] GO:0090240 [positive regulation of histone H4 acetylation] GO:1902166 [negative regulation of intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator] Show all	198 aa 21.7 kDa	Yes	0
MUC1-201 ENSP00000343482 ENST00000338684	A0A0A0MRB3 [Direct mapping] Mucin-1 Show all	Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based 1TM proteins predicted by MDM Cancer-related genes COSMIC somatic mutations in cancer genes COSMIC Somatic Mutations COSMIC Translocations Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0016021 [integral component of membrane] Show all	241 aa 25.7 kDa	Yes	1
MUC1-202 ENSP00000388172 ENST00000457295	A0A0A0MSH4 [Direct mapping] Mucin-1 Show all	Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based 1TM proteins predicted by MDM Cancer-related genes COSMIC somatic mutations in cancer genes COSMIC Somatic Mutations COSMIC Translocations Protein evidence (Ezkurdia et al 2014) Show all	GO:0016021 [integral component of membrane] Show all	268 aa 29.6 kDa	Yes	1
MUC1-203 ENSP00000480335 ENST00000462215	A0A087WWM2 [Direct mapping] Mucin-1 Show all	MEMSAT3 predicted membrane proteins Predicted secreted proteins Secreted proteins predicted by MDSEC SignalP predicted secreted proteins Phobius predicted secreted proteins SPOCTOPUS predicted secreted proteins Cancer-related genes COSMIC somatic mutations in cancer genes COSMIC Somatic Mutations COSMIC Translocations Protein evidence (Ezkurdia et al 2014) Show all		135 aa 14.2 kDa	Yes	0
MUC1-204 ENSP00000483482 ENST00000610359	A0A087X0L2 [Direct mapping] Mucin-1 Show all	Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based 1TM proteins predicted by MDM Cancer-related genes COSMIC somatic mutations in cancer genes COSMIC Somatic Mutations COSMIC Translocations Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0016021 [integral component of membrane] Show all	239 aa 25.4 kDa	Yes	1
MUC1-205 ENSP00000480333 ENST00000611571	A0A087WWM1 [Direct mapping] Mucin-1 Show all	Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based 1TM proteins predicted by MDM Cancer-related genes COSMIC somatic mutations in cancer genes COSMIC Somatic Mutations COSMIC Translocations Protein evidence (Ezkurdia et al 2014) Show all	GO:0016021 [integral component of membrane] Show all	1262 aa 123 kDa	Yes	1
MUC1-206 ENSP00000483581 ENST00000611577	A6ZIE3 [Direct mapping] MUC1 isoform M9; Mucin-1 Show all	Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based 1TM proteins predicted by MDM Cancer-related genes COSMIC somatic mutations in cancer genes COSMIC Somatic Mutations COSMIC Translocations Protein evidence (Ezkurdia et al 2014) Show all	GO:0016021 [integral component of membrane] Show all	213 aa 21.9 kDa	Yes	1
MUC1-207 ENSP00000484824 ENST00000612778	A0A087X2A4 [Direct mapping] Mucin-1 Show all	Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based 1TM proteins predicted by MDM Cancer-related genes COSMIC somatic mutations in cancer genes COSMIC Somatic Mutations COSMIC Translocations Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0001666 [response to hypoxia] GO:0001701 [in utero embryonic development] GO:0005737 [cytoplasm] GO:0005886 [plasma membrane] GO:0007565 [female pregnancy] GO:0016021 [integral component of membrane] GO:0016324 [apical plasma membrane] GO:0030855 [epithelial cell differentiation] GO:0071300 [cellular response to retinoic acid] Show all	484 aa 50.1 kDa	Yes	1
MUC1-208 ENSP00000482988 ENST00000614519	A0A087WZZ6 [Direct mapping] Mucin-1 Show all	Predicted secreted proteins Secreted proteins predicted by MDSEC SignalP predicted secreted proteins Phobius predicted secreted proteins SPOCTOPUS predicted secreted proteins Cancer-related genes COSMIC somatic mutations in cancer genes COSMIC Somatic Mutations COSMIC Translocations Protein evidence (Ezkurdia et al 2014) Show all		123 aa 13.3 kDa	Yes	0
MUC1-209 ENSP00000483473 ENST00000615517	A6ZIE4 [Direct mapping] MUC1 isoform M10; Mucin-1 Show all	Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based 1TM proteins predicted by MDM Cancer-related genes COSMIC somatic mutations in cancer genes COSMIC Somatic Mutations COSMIC Translocations Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0016021 [integral component of membrane] Show all	189 aa 20 kDa	Yes	1