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This gene encodes a membrane-bound protein that is a member of the mucin family. Mucins are O-glycosylated proteins that play an essential role in forming protective mucous barriers on epithelial surfaces. These proteins also play a role in intracellular signaling. This protein is expressed on the apical surface of epithelial cells that line the mucosal surfaces of many different tissues including lung, breast stomach and pancreas. This protein is proteolytically cleaved into alpha and beta subunits that form a heterodimeric complex. The N-terminal alpha subunit functions in cell-adhesion and the C-terminal beta subunit is involved in cell signaling. Overexpression, aberrant intracellular localization, and changes in glycosylation of this protein have been associated with carcinomas. This gene is known to contain a highly polymorphic variable number tandem repeats (VNTR) domain. Alternate splicing results in multiple transcript variants.[provided by RefSeq, Feb 2011]
CD markers Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based 1TM proteins predicted by MDM Cancer-related genes Candidate cancer biomarkers COSMIC somatic mutations in cancer genes COSMIC Somatic Mutations COSMIC Translocations Disease related genes Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014)
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GO:0000790 [nuclear chromatin] GO:0000978 [RNA polymerase II core promoter proximal region sequence-specific DNA binding] GO:0002039 [p53 binding] GO:0003712 [transcription cofactor activity] GO:0005515 [protein binding] GO:0005615 [extracellular space] GO:0005796 [Golgi lumen] GO:0005887 [integral component of plasma membrane] GO:0006493 [protein O-linked glycosylation] GO:0006977 [DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest] GO:0006978 [DNA damage response, signal transduction by p53 class mediator resulting in transcription of p21 class mediator] GO:0010944 [negative regulation of transcription by competitive promoter binding] GO:0016266 [O-glycan processing] GO:0016324 [apical plasma membrane] GO:0031982 [vesicle] GO:0033629 [negative regulation of cell adhesion mediated by integrin] GO:0036003 [positive regulation of transcription from RNA polymerase II promoter in response to stress] GO:0043618 [regulation of transcription from RNA polymerase II promoter in response to stress] GO:0043687 [post-translational protein modification] GO:0044267 [cellular protein metabolic process] GO:0070062 [extracellular exosome] GO:0090240 [positive regulation of histone H4 acetylation] GO:1902166 [negative regulation of intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator]
CD markers THUMBUP predicted membrane proteins Predicted secreted proteins Secreted proteins predicted by MDSEC SignalP predicted secreted proteins Phobius predicted secreted proteins SPOCTOPUS predicted secreted proteins Cancer-related genes Candidate cancer biomarkers COSMIC somatic mutations in cancer genes COSMIC Somatic Mutations COSMIC Translocations Disease related genes Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014)
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GO:0000790 [nuclear chromatin] GO:0000978 [RNA polymerase II core promoter proximal region sequence-specific DNA binding] GO:0002039 [p53 binding] GO:0003712 [transcription cofactor activity] GO:0005515 [protein binding] GO:0005615 [extracellular space] GO:0005796 [Golgi lumen] GO:0005887 [integral component of plasma membrane] GO:0006493 [protein O-linked glycosylation] GO:0006977 [DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest] GO:0006978 [DNA damage response, signal transduction by p53 class mediator resulting in transcription of p21 class mediator] GO:0010944 [negative regulation of transcription by competitive promoter binding] GO:0016266 [O-glycan processing] GO:0016324 [apical plasma membrane] GO:0031982 [vesicle] GO:0033629 [negative regulation of cell adhesion mediated by integrin] GO:0036003 [positive regulation of transcription from RNA polymerase II promoter in response to stress] GO:0043618 [regulation of transcription from RNA polymerase II promoter in response to stress] GO:0043687 [post-translational protein modification] GO:0044267 [cellular protein metabolic process] GO:0070062 [extracellular exosome] GO:0090240 [positive regulation of histone H4 acetylation] GO:1902166 [negative regulation of intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator]
CD markers MEMSAT3 predicted membrane proteins Predicted secreted proteins Secreted proteins predicted by MDSEC SignalP predicted secreted proteins Phobius predicted secreted proteins SPOCTOPUS predicted secreted proteins Cancer-related genes Candidate cancer biomarkers COSMIC somatic mutations in cancer genes COSMIC Somatic Mutations COSMIC Translocations Disease related genes Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000790 [nuclear chromatin] GO:0000978 [RNA polymerase II core promoter proximal region sequence-specific DNA binding] GO:0002039 [p53 binding] GO:0003712 [transcription cofactor activity] GO:0005515 [protein binding] GO:0005615 [extracellular space] GO:0005796 [Golgi lumen] GO:0005887 [integral component of plasma membrane] GO:0006493 [protein O-linked glycosylation] GO:0006977 [DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest] GO:0006978 [DNA damage response, signal transduction by p53 class mediator resulting in transcription of p21 class mediator] GO:0010944 [negative regulation of transcription by competitive promoter binding] GO:0016266 [O-glycan processing] GO:0016324 [apical plasma membrane] GO:0031982 [vesicle] GO:0033629 [negative regulation of cell adhesion mediated by integrin] GO:0036003 [positive regulation of transcription from RNA polymerase II promoter in response to stress] GO:0043618 [regulation of transcription from RNA polymerase II promoter in response to stress] GO:0043687 [post-translational protein modification] GO:0044267 [cellular protein metabolic process] GO:0070062 [extracellular exosome] GO:0090240 [positive regulation of histone H4 acetylation] GO:1902166 [negative regulation of intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator]
CD markers Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based 1TM proteins predicted by MDM Cancer-related genes Candidate cancer biomarkers COSMIC somatic mutations in cancer genes COSMIC Somatic Mutations COSMIC Translocations Disease related genes Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000790 [nuclear chromatin] GO:0000978 [RNA polymerase II core promoter proximal region sequence-specific DNA binding] GO:0002039 [p53 binding] GO:0003712 [transcription cofactor activity] GO:0005515 [protein binding] GO:0005615 [extracellular space] GO:0005796 [Golgi lumen] GO:0005887 [integral component of plasma membrane] GO:0006493 [protein O-linked glycosylation] GO:0006977 [DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest] GO:0006978 [DNA damage response, signal transduction by p53 class mediator resulting in transcription of p21 class mediator] GO:0010944 [negative regulation of transcription by competitive promoter binding] GO:0016266 [O-glycan processing] GO:0016324 [apical plasma membrane] GO:0031982 [vesicle] GO:0033629 [negative regulation of cell adhesion mediated by integrin] GO:0036003 [positive regulation of transcription from RNA polymerase II promoter in response to stress] GO:0043618 [regulation of transcription from RNA polymerase II promoter in response to stress] GO:0043687 [post-translational protein modification] GO:0044267 [cellular protein metabolic process] GO:0070062 [extracellular exosome] GO:0090240 [positive regulation of histone H4 acetylation] GO:1902166 [negative regulation of intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator]
CD markers Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based 1TM proteins predicted by MDM Cancer-related genes Candidate cancer biomarkers COSMIC somatic mutations in cancer genes COSMIC Somatic Mutations COSMIC Translocations Disease related genes Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000790 [nuclear chromatin] GO:0000978 [RNA polymerase II core promoter proximal region sequence-specific DNA binding] GO:0002039 [p53 binding] GO:0003712 [transcription cofactor activity] GO:0005515 [protein binding] GO:0005615 [extracellular space] GO:0005796 [Golgi lumen] GO:0005887 [integral component of plasma membrane] GO:0006493 [protein O-linked glycosylation] GO:0006977 [DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest] GO:0006978 [DNA damage response, signal transduction by p53 class mediator resulting in transcription of p21 class mediator] GO:0010944 [negative regulation of transcription by competitive promoter binding] GO:0016266 [O-glycan processing] GO:0016324 [apical plasma membrane] GO:0031982 [vesicle] GO:0033629 [negative regulation of cell adhesion mediated by integrin] GO:0036003 [positive regulation of transcription from RNA polymerase II promoter in response to stress] GO:0043618 [regulation of transcription from RNA polymerase II promoter in response to stress] GO:0043687 [post-translational protein modification] GO:0044267 [cellular protein metabolic process] GO:0070062 [extracellular exosome] GO:0090240 [positive regulation of histone H4 acetylation] GO:1902166 [negative regulation of intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator]
CD markers Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based 1TM proteins predicted by MDM Cancer-related genes Candidate cancer biomarkers COSMIC somatic mutations in cancer genes COSMIC Somatic Mutations COSMIC Translocations Disease related genes Protein evidence (Ezkurdia et al 2014)
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GO:0000790 [nuclear chromatin] GO:0000978 [RNA polymerase II core promoter proximal region sequence-specific DNA binding] GO:0002039 [p53 binding] GO:0003712 [transcription cofactor activity] GO:0005515 [protein binding] GO:0005615 [extracellular space] GO:0005796 [Golgi lumen] GO:0005887 [integral component of plasma membrane] GO:0006493 [protein O-linked glycosylation] GO:0006977 [DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest] GO:0006978 [DNA damage response, signal transduction by p53 class mediator resulting in transcription of p21 class mediator] GO:0010944 [negative regulation of transcription by competitive promoter binding] GO:0016266 [O-glycan processing] GO:0016324 [apical plasma membrane] GO:0031982 [vesicle] GO:0033629 [negative regulation of cell adhesion mediated by integrin] GO:0036003 [positive regulation of transcription from RNA polymerase II promoter in response to stress] GO:0043618 [regulation of transcription from RNA polymerase II promoter in response to stress] GO:0043687 [post-translational protein modification] GO:0044267 [cellular protein metabolic process] GO:0070062 [extracellular exosome] GO:0090240 [positive regulation of histone H4 acetylation] GO:1902166 [negative regulation of intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator]
CD markers Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based 1TM proteins predicted by MDM Cancer-related genes Candidate cancer biomarkers COSMIC somatic mutations in cancer genes COSMIC Somatic Mutations COSMIC Translocations Disease related genes Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000790 [nuclear chromatin] GO:0000978 [RNA polymerase II core promoter proximal region sequence-specific DNA binding] GO:0002039 [p53 binding] GO:0003712 [transcription cofactor activity] GO:0005515 [protein binding] GO:0005615 [extracellular space] GO:0005796 [Golgi lumen] GO:0005887 [integral component of plasma membrane] GO:0006493 [protein O-linked glycosylation] GO:0006977 [DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest] GO:0006978 [DNA damage response, signal transduction by p53 class mediator resulting in transcription of p21 class mediator] GO:0010944 [negative regulation of transcription by competitive promoter binding] GO:0016266 [O-glycan processing] GO:0016324 [apical plasma membrane] GO:0031982 [vesicle] GO:0033629 [negative regulation of cell adhesion mediated by integrin] GO:0036003 [positive regulation of transcription from RNA polymerase II promoter in response to stress] GO:0043618 [regulation of transcription from RNA polymerase II promoter in response to stress] GO:0043687 [post-translational protein modification] GO:0044267 [cellular protein metabolic process] GO:0070062 [extracellular exosome] GO:0090240 [positive regulation of histone H4 acetylation] GO:1902166 [negative regulation of intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator]
CD markers Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based 1TM proteins predicted by MDM Cancer-related genes Candidate cancer biomarkers COSMIC somatic mutations in cancer genes COSMIC Somatic Mutations COSMIC Translocations Disease related genes Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000790 [nuclear chromatin] GO:0000978 [RNA polymerase II core promoter proximal region sequence-specific DNA binding] GO:0002039 [p53 binding] GO:0003712 [transcription cofactor activity] GO:0005515 [protein binding] GO:0005615 [extracellular space] GO:0005796 [Golgi lumen] GO:0005887 [integral component of plasma membrane] GO:0006493 [protein O-linked glycosylation] GO:0006977 [DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest] GO:0006978 [DNA damage response, signal transduction by p53 class mediator resulting in transcription of p21 class mediator] GO:0010944 [negative regulation of transcription by competitive promoter binding] GO:0016266 [O-glycan processing] GO:0016324 [apical plasma membrane] GO:0031982 [vesicle] GO:0033629 [negative regulation of cell adhesion mediated by integrin] GO:0036003 [positive regulation of transcription from RNA polymerase II promoter in response to stress] GO:0043618 [regulation of transcription from RNA polymerase II promoter in response to stress] GO:0043687 [post-translational protein modification] GO:0044267 [cellular protein metabolic process] GO:0070062 [extracellular exosome] GO:0090240 [positive regulation of histone H4 acetylation] GO:1902166 [negative regulation of intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator]
CD markers THUMBUP predicted membrane proteins Predicted secreted proteins Secreted proteins predicted by MDSEC SignalP predicted secreted proteins Phobius predicted secreted proteins SPOCTOPUS predicted secreted proteins Cancer-related genes Candidate cancer biomarkers COSMIC somatic mutations in cancer genes COSMIC Somatic Mutations COSMIC Translocations Disease related genes Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000790 [nuclear chromatin] GO:0000978 [RNA polymerase II core promoter proximal region sequence-specific DNA binding] GO:0002039 [p53 binding] GO:0003712 [transcription cofactor activity] GO:0005515 [protein binding] GO:0005615 [extracellular space] GO:0005796 [Golgi lumen] GO:0005887 [integral component of plasma membrane] GO:0006493 [protein O-linked glycosylation] GO:0006977 [DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest] GO:0006978 [DNA damage response, signal transduction by p53 class mediator resulting in transcription of p21 class mediator] GO:0010944 [negative regulation of transcription by competitive promoter binding] GO:0016266 [O-glycan processing] GO:0016324 [apical plasma membrane] GO:0031982 [vesicle] GO:0033629 [negative regulation of cell adhesion mediated by integrin] GO:0036003 [positive regulation of transcription from RNA polymerase II promoter in response to stress] GO:0043618 [regulation of transcription from RNA polymerase II promoter in response to stress] GO:0043687 [post-translational protein modification] GO:0044267 [cellular protein metabolic process] GO:0070062 [extracellular exosome] GO:0090240 [positive regulation of histone H4 acetylation] GO:1902166 [negative regulation of intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator]
