Cell atlas - PRKG1 - The Human Protein Atlas

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PRKG1

TISSUE

CELL

PATHOLOGY

CELL ATLAS RNA EXPRESSION HUMAN CELLS

GENE/PROTEIN

Antibody validation

Dictionary
	Cytosol
	Vesicles

Human cell
	Cytosol
	Vesicles

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GENERAL INFORMATION
Gene name	PRKG1
Gene description	Protein kinase, cGMP-dependent, type I
Protein class	Disease related genes Enzymes Plasma proteins Potential drug targets Predicted intracellular proteins
Predicted localization	Intracellular
Number of transcripts	4
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HUMAN PROTEIN ATLAS INFORMATION
Summary	Localized to the cytosol & vesicles.
RNA cell category	Cell line enhanced (AN3-CA, BJ hTERT+, U-138 MG)
Protein evidence	Evidence at protein level
Main location	Localized to the Vesicles (approved), Cytosol (approved)

DATA RELIABILITY
Reliability score	Approved based on 1 antibody. HPA007699
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ASSAYS

RNA EXPRESSION OVERVIEW
RNA cell line category: Cell line enhanced (AN3-CA, BJ hTERT+, U-138 MG) Organ Origin Category Expression Alphabetical Cell lines sorted after organ of phenotypic resemblance. Cell lines sorted after biological source for establishment. Cell lines sorted after the cell line category according to Cellosaurus. Cell lines sorted on descending RNA expression. Cell lines sorted alphabetically.

HUMAN CELLS

Summary

Localized to the cytosol & vesicles.

Main location

Vesicles (approved), Cytosol (approved)


	Toggle channels	Low High G1 S G2 M N/A

Thumbnail	Antibody	Cell line	Location	Single-cell variation	Cell cycle dependent variation
	HPA007699	HEK 293	Vesicles
	HPA007699	U-2 OS	Cytosol
	HPA007699	U-251 MG	Cytosol

GENE INFORMATION
Gene name	PRKG1 (HGNC Symbol)
Synonyms	PGK, PKG, PRKG1B, PRKGR1B
Description	Protein kinase, cGMP-dependent, type I (HGNC Symbol)
Entrez gene summary	Mammals have three different isoforms of cyclic GMP-dependent protein kinase (Ialpha, Ibeta, and II). These PRKG isoforms act as key mediators of the nitric oxide/cGMP signaling pathway and are important components of many signal transduction processes in diverse cell types. This PRKG1 gene on human chromosome 10 encodes the soluble Ialpha and Ibeta isoforms of PRKG by alternative transcript splicing. A separate gene on human chromosome 4, PRKG2, encodes the membrane-bound PRKG isoform II. The PRKG1 proteins play a central role in regulating cardiovascular and neuronal functions in addition to relaxing smooth muscle tone, preventing platelet aggregation, and modulating cell growth. This gene is most strongly expressed in all types of smooth muscle, platelets, cerebellar Purkinje cells, hippocampal neurons, and the lateral amygdala. Isoforms Ialpha and Ibeta have identical cGMP-binding and catalytic domains but differ in their leucine/isoleucine zipper and autoinhibitory sequences and therefore differ in their dimerization substrates and kinase enzyme activity. [provided by RefSeq, Sep 2011]
Chromosome	10
Cytoband
Chromosome location (bp)	50991358 - 52298350
Protein evidence	Evidence at protein level (all genes)
Ensembl	ENSG00000185532 (version 83.38)
Entrez gene	5592
UniProt	Q13976 (UniProt - Evidence at protein level)
neXtProt	NX_Q13976
Antibodypedia	PRKG1 antibodies

PROTEIN BROWSER

PRKG1-001	PRKG1-002	PRKG1-004	PRKG1-201

PROTEIN INFORMATION
Splice variant	UniProt	Protein class	Gene ontology	Length & mass	Signal peptide (predicted)	Transmembrane regions (predicted)
PRKG1-001 ENSP00000363097 ENST00000373985	Q13976 [Direct mapping] cGMP-dependent protein kinase 1 Show all	Enzymes ENZYME proteins Transferases Kinases AGC Ser/Thr protein kinases MEMSAT-SVM predicted membrane proteins SPOCTOPUS predicted membrane proteins Predicted intracellular proteins Plasma proteins Disease related genes Potential drug targets Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0004672 [protein kinase activity] GO:0004674 [protein serine/threonine kinase activity] GO:0004692 [cGMP-dependent protein kinase activity] GO:0005246 [calcium channel regulator activity] GO:0005515 [protein binding] GO:0005524 [ATP binding] GO:0005737 [cytoplasm] GO:0005829 [cytosol] GO:0005886 [plasma membrane] GO:0006468 [protein phosphorylation] GO:0007165 [signal transduction] GO:0007596 [blood coagulation] GO:0030036 [actin cytoskeleton organization] GO:0043087 [regulation of GTPase activity] GO:0090331 [negative regulation of platelet aggregation] GO:0098779 [mitophagy in response to mitochondrial depolarization] Show all	671 aa 76.4 kDa	No	0
PRKG1-002 ENSP00000363092 ENST00000373980	Q13976 [Direct mapping] cGMP-dependent protein kinase 1 Show all	Enzymes ENZYME proteins Transferases Kinases AGC Ser/Thr protein kinases SPOCTOPUS predicted membrane proteins Predicted intracellular proteins Plasma proteins Disease related genes Potential drug targets Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0001764 [neuron migration] GO:0004672 [protein kinase activity] GO:0004674 [protein serine/threonine kinase activity] GO:0004692 [cGMP-dependent protein kinase activity] GO:0005246 [calcium channel regulator activity] GO:0005515 [protein binding] GO:0005524 [ATP binding] GO:0005737 [cytoplasm] GO:0005794 [Golgi apparatus] GO:0005829 [cytosol] GO:0005886 [plasma membrane] GO:0006468 [protein phosphorylation] GO:0007165 [signal transduction] GO:0007596 [blood coagulation] GO:0016358 [dendrite development] GO:0019934 [cGMP-mediated signaling] GO:0030036 [actin cytoskeleton organization] GO:0030553 [cGMP binding] GO:0030900 [forebrain development] GO:0043087 [regulation of GTPase activity] GO:0045986 [negative regulation of smooth muscle contraction] GO:0060087 [relaxation of vascular smooth muscle] GO:0090331 [negative regulation of platelet aggregation] GO:0098779 [mitophagy in response to mitochondrial depolarization] Show all	686 aa 77.8 kDa	No	0
PRKG1-004 ENSP00000363087 ENST00000373976	B1ALS0 [Direct mapping] cGMP-dependent protein kinase 1 Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0004692 [cGMP-dependent protein kinase activity] GO:0005524 [ATP binding] GO:0006468 [protein phosphorylation] Show all	181 aa 20.5 kDa	No	0
PRKG1-201 ENSP00000384200 ENST00000401604	A0A0A0MSB3 [Direct mapping] cGMP-dependent protein kinase 1 Show all	SPOCTOPUS predicted membrane proteins Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0004672 [protein kinase activity] GO:0004674 [protein serine/threonine kinase activity] GO:0004692 [cGMP-dependent protein kinase activity] GO:0005524 [ATP binding] GO:0006468 [protein phosphorylation] Show all	459 aa 51.9 kDa	No	0

Contact

contact@proteinatlas.org

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.