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PRKG1

GENERAL INFORMATION

Gene name

 PRKG1

Gene description

 Protein kinase, cGMP-dependent, type I

Protein class

 Disease related genes
Enzymes
Plasma proteins
Potential drug targets
Predicted intracellular proteins

Predicted localization

 Intracellular

Number of transcripts

 4
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HUMAN PROTEIN ATLAS INFORMATION

RNA category
TCGA (cancer tissue):Mixed
HPA (cell line):Cell line enhanced (AN3-CA, BJ hTERT+, U-138 MG)
HPA (normal tissue):Mixed

Protein evidence

 Evidence at protein level

Protein expression
normal tissue

 General cytoplasmic expression.

ANTIBODY IHC RELIABILITY

Data reliability
description

 Antibody staining mainly consistent with RNA expression data.

Reliability score

 Approved based on 2 antibodies.
HPA007699 , CAB009629
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PROGNOSTIC SUMMARY
Gene product is not prognostic.
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RNA EXPRESSION OVERVIEW
TCGA dataset
RNA cancer category: Mixed

PROTEIN EXPRESSION
Colorectal cancer
Breast cancer
Prostate cancer
Lung cancer
Melanoma

STAINING SUMMARY
HPA007699
CAB009629

GENE INFORMATION

Gene name

 PRKG1 (HGNC Symbol)

Synonyms

 PGK, PKG, PRKG1B, PRKGR1B

Description

 Protein kinase, cGMP-dependent, type I (HGNC Symbol)

Entrez gene summary

 Mammals have three different isoforms of cyclic GMP-dependent protein kinase (Ialpha, Ibeta, and II). These PRKG isoforms act as key mediators of the nitric oxide/cGMP signaling pathway and are important components of many signal transduction processes in diverse cell types. This PRKG1 gene on human chromosome 10 encodes the soluble Ialpha and Ibeta isoforms of PRKG by alternative transcript splicing. A separate gene on human chromosome 4, PRKG2, encodes the membrane-bound PRKG isoform II. The PRKG1 proteins play a central role in regulating cardiovascular and neuronal functions in addition to relaxing smooth muscle tone, preventing platelet aggregation, and modulating cell growth. This gene is most strongly expressed in all types of smooth muscle, platelets, cerebellar Purkinje cells, hippocampal neurons, and the lateral amygdala. Isoforms Ialpha and Ibeta have identical cGMP-binding and catalytic domains but differ in their leucine/isoleucine zipper and autoinhibitory sequences and therefore differ in their dimerization substrates and kinase enzyme activity. [provided by RefSeq, Sep 2011]

Chromosome

 10

Cytoband

Chromosome location (bp)

 50991358 - 52298350

Protein evidence

 Evidence at protein level (all genes)

Ensembl

 ENSG00000185532 (version 83.38)

Entrez gene

 5592

UniProt

 Q13976 (UniProt - Evidence at protein level)

neXtProt

 NX_Q13976

Antibodypedia

 PRKG1 antibodies

PROTEIN BROWSER
PRKG1-001
PRKG1-002
PRKG1-004
PRKG1-201

PROTEIN INFORMATION

Splice variant

UniProt

Protein class

Gene ontology

Length & mass

Signal peptide
(predicted)

Transmembrane regions
(predicted)
PRKG1-001
ENSP00000363097
ENST00000373985
Q13976 [Direct mapping]
cGMP-dependent protein kinase 1
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Enzymes
   ENZYME proteins
   Transferases
   Kinases
   AGC Ser/Thr protein kinases
   MEMSAT-SVM predicted membrane proteins
   SPOCTOPUS predicted membrane proteins
Predicted intracellular proteins
Plasma proteins
Disease related genes
Potential drug targets
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
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GO:0004672 [protein kinase activity]
GO:0004674 [protein serine/threonine kinase activity]
GO:0004692 [cGMP-dependent protein kinase activity]
GO:0005246 [calcium channel regulator activity]
GO:0005515 [protein binding]
GO:0005524 [ATP binding]
GO:0005737 [cytoplasm]
GO:0005829 [cytosol]
GO:0005886 [plasma membrane]
GO:0006468 [protein phosphorylation]
GO:0007165 [signal transduction]
GO:0007596 [blood coagulation]
GO:0030036 [actin cytoskeleton organization]
GO:0043087 [regulation of GTPase activity]
GO:0090331 [negative regulation of platelet aggregation]
GO:0098779 [mitophagy in response to mitochondrial depolarization]
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 671 aa
76.4 kDa 		No 0
PRKG1-002
ENSP00000363092
ENST00000373980
Q13976 [Direct mapping]
cGMP-dependent protein kinase 1
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Enzymes
   ENZYME proteins
   Transferases
   Kinases
   AGC Ser/Thr protein kinases
   SPOCTOPUS predicted membrane proteins
Predicted intracellular proteins
Plasma proteins
Disease related genes
Potential drug targets
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0001764 [neuron migration]
GO:0004672 [protein kinase activity]
GO:0004674 [protein serine/threonine kinase activity]
GO:0004692 [cGMP-dependent protein kinase activity]
GO:0005246 [calcium channel regulator activity]
GO:0005515 [protein binding]
GO:0005524 [ATP binding]
GO:0005737 [cytoplasm]
GO:0005794 [Golgi apparatus]
GO:0005829 [cytosol]
GO:0005886 [plasma membrane]
GO:0006468 [protein phosphorylation]
GO:0007165 [signal transduction]
GO:0007596 [blood coagulation]
GO:0016358 [dendrite development]
GO:0019934 [cGMP-mediated signaling]
GO:0030036 [actin cytoskeleton organization]
GO:0030553 [cGMP binding]
GO:0030900 [forebrain development]
GO:0043087 [regulation of GTPase activity]
GO:0045986 [negative regulation of smooth muscle contraction]
GO:0060087 [relaxation of vascular smooth muscle]
GO:0090331 [negative regulation of platelet aggregation]
GO:0098779 [mitophagy in response to mitochondrial depolarization]
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 686 aa
77.8 kDa 		No 0
PRKG1-004
ENSP00000363087
ENST00000373976
B1ALS0 [Direct mapping]
cGMP-dependent protein kinase 1
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Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
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GO:0004692 [cGMP-dependent protein kinase activity]
GO:0005524 [ATP binding]
GO:0006468 [protein phosphorylation]
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 181 aa
20.5 kDa 		No 0
PRKG1-201
ENSP00000384200
ENST00000401604
A0A0A0MSB3 [Direct mapping]
cGMP-dependent protein kinase 1
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   SPOCTOPUS predicted membrane proteins
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0004672 [protein kinase activity]
GO:0004674 [protein serine/threonine kinase activity]
GO:0004692 [cGMP-dependent protein kinase activity]
GO:0005524 [ATP binding]
GO:0006468 [protein phosphorylation]
Show all
 459 aa
51.9 kDa 		No 0

Contact

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.