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NR2F2

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GENERAL INFORMATION

Gene name

 NR2F2

Gene description

 Nuclear receptor subfamily 2, group F, member 2

Protein class

 Disease related genes
Nuclear receptors
Predicted intracellular proteins
Transcription factors

Predicted localization

 Intracellular

Number of transcripts

 5
SHOW MORE

HUMAN PROTEIN ATLAS INFORMATION

Summary

RNA cell category

 Mixed

Protein evidence

 Evidence at protein level

Main location

 Not available

DATA RELIABILITY

Reliability score

 Pending cell analysis.

ASSAYS
RNA expression

RNA EXPRESSION OVERVIEW
RNA cell line category: Mixed
Organ
Origin
Category
Expression
Alphabetical
Cell lines sorted after organ of phenotypic resemblance.

GENE INFORMATION

Gene name

 NR2F2 (HGNC Symbol)

Synonyms

 ARP1, COUP-TFII, COUPTFB, NF-E3, SVP40, TFCOUP2

Description

 Nuclear receptor subfamily 2, group F, member 2 (HGNC Symbol)

Entrez gene summary

 This gene encodes a member of the steroid thyroid hormone superfamily of nuclear receptors. The encoded protein is a ligand inducible transcription factor that is involved in the regulation of many different genes. Alternate splicing results in multiple transcript variants. [provided by RefSeq, Mar 2010]

Chromosome

 15

Cytoband

 q26.2

Chromosome location (bp)

 96325938 - 96340263

Protein evidence

 Evidence at protein level (all genes)

Ensembl

 ENSG00000185551 (version 83.38)

Entrez gene

 7026

UniProt

 P24468 (UniProt - Evidence at protein level)

neXtProt

 NX_P24468

Antibodypedia

 NR2F2 antibodies

PROTEIN BROWSER
NR2F2-001
NR2F2-002
NR2F2-003
NR2F2-004
NR2F2-201

PROTEIN INFORMATION

Splice variant

UniProt

Protein class

Gene ontology

Length & mass

Signal peptide
(predicted)

Transmembrane regions
(predicted)
NR2F2-001
ENSP00000377721
ENST00000394166
P24468 [Direct mapping]
COUP transcription factor 2
F1D8R0 [Target identity:100%; Query identity:100%]
Nuclear receptor subfamily 2, group F, member 2, isoform CRA_a; Ovalbumin upstream promoter-transcription factor II variant 1
Show all
Nuclear receptors
Predicted intracellular proteins
Transcription factors
   Zinc-coordinating DNA-binding domains
Disease related genes
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000122 [negative regulation of transcription from RNA polymerase II promoter]
GO:0001701 [in utero embryonic development]
GO:0001764 [neuron migration]
GO:0001893 [maternal placenta development]
GO:0001937 [negative regulation of endothelial cell proliferation]
GO:0001945 [lymph vessel development]
GO:0001972 [retinoic acid binding]
GO:0003677 [DNA binding]
GO:0003700 [transcription factor activity, sequence-specific DNA binding]
GO:0003707 [steroid hormone receptor activity]
GO:0003714 [transcription corepressor activity]
GO:0004879 [RNA polymerase II transcription factor activity, ligand-activated sequence-specific DNA binding]
GO:0005515 [protein binding]
GO:0005634 [nucleus]
GO:0006351 [transcription, DNA-templated]
GO:0006355 [regulation of transcription, DNA-templated]
GO:0006357 [regulation of transcription from RNA polymerase II promoter]
GO:0006629 [lipid metabolic process]
GO:0007165 [signal transduction]
GO:0007519 [skeletal muscle tissue development]
GO:0008270 [zinc ion binding]
GO:0009566 [fertilization]
GO:0009952 [anterior/posterior pattern specification]
GO:0009956 [radial pattern formation]
GO:0010596 [negative regulation of endothelial cell migration]
GO:0030522 [intracellular receptor signaling pathway]
GO:0030900 [forebrain development]
GO:0032355 [response to estradiol]
GO:0042803 [protein homodimerization activity]
GO:0043401 [steroid hormone mediated signaling pathway]
GO:0043565 [sequence-specific DNA binding]
GO:0045736 [negative regulation of cyclin-dependent protein serine/threonine kinase activity]
GO:0045892 [negative regulation of transcription, DNA-templated]
GO:0045893 [positive regulation of transcription, DNA-templated]
GO:0048514 [blood vessel morphogenesis]
GO:0060173 [limb development]
GO:0060674 [placenta blood vessel development]
GO:0060707 [trophoblast giant cell differentiation]
GO:0060849 [regulation of transcription involved in lymphatic endothelial cell fate commitment]
Show all
 414 aa
45.6 kDa 		No 0
NR2F2-002
ENSP00000401674
ENST00000421109
P24468 [Direct mapping]
COUP transcription factor 2
Show all
Nuclear receptors
Predicted intracellular proteins
Transcription factors
   Zinc-coordinating DNA-binding domains
Disease related genes
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000122 [negative regulation of transcription from RNA polymerase II promoter]
GO:0001937 [negative regulation of endothelial cell proliferation]
GO:0001972 [retinoic acid binding]
GO:0003700 [transcription factor activity, sequence-specific DNA binding]
GO:0003707 [steroid hormone receptor activity]
GO:0003714 [transcription corepressor activity]
GO:0004879 [RNA polymerase II transcription factor activity, ligand-activated sequence-specific DNA binding]
GO:0005515 [protein binding]
GO:0005634 [nucleus]
GO:0006351 [transcription, DNA-templated]
GO:0006355 [regulation of transcription, DNA-templated]
GO:0006357 [regulation of transcription from RNA polymerase II promoter]
GO:0006629 [lipid metabolic process]
GO:0007165 [signal transduction]
GO:0008270 [zinc ion binding]
GO:0010596 [negative regulation of endothelial cell migration]
GO:0030522 [intracellular receptor signaling pathway]
GO:0042803 [protein homodimerization activity]
GO:0043401 [steroid hormone mediated signaling pathway]
GO:0043565 [sequence-specific DNA binding]
GO:0045736 [negative regulation of cyclin-dependent protein serine/threonine kinase activity]
GO:0045892 [negative regulation of transcription, DNA-templated]
GO:0045893 [positive regulation of transcription, DNA-templated]
GO:0060849 [regulation of transcription involved in lymphatic endothelial cell fate commitment]
Show all
 281 aa
31.5 kDa 		No 0
NR2F2-003
ENSP00000389853
ENST00000453270
P24468 [Direct mapping]
COUP transcription factor 2
Show all
Nuclear receptors
Predicted intracellular proteins
Transcription factors
   Zinc-coordinating DNA-binding domains
Disease related genes
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000122 [negative regulation of transcription from RNA polymerase II promoter]
GO:0001937 [negative regulation of endothelial cell proliferation]
GO:0001972 [retinoic acid binding]
GO:0003700 [transcription factor activity, sequence-specific DNA binding]
GO:0003707 [steroid hormone receptor activity]
GO:0003714 [transcription corepressor activity]
GO:0004879 [RNA polymerase II transcription factor activity, ligand-activated sequence-specific DNA binding]
GO:0005515 [protein binding]
GO:0005634 [nucleus]
GO:0006351 [transcription, DNA-templated]
GO:0006355 [regulation of transcription, DNA-templated]
GO:0006357 [regulation of transcription from RNA polymerase II promoter]
GO:0006629 [lipid metabolic process]
GO:0007165 [signal transduction]
GO:0008270 [zinc ion binding]
GO:0010596 [negative regulation of endothelial cell migration]
GO:0030522 [intracellular receptor signaling pathway]
GO:0042803 [protein homodimerization activity]
GO:0043401 [steroid hormone mediated signaling pathway]
GO:0043565 [sequence-specific DNA binding]
GO:0045736 [negative regulation of cyclin-dependent protein serine/threonine kinase activity]
GO:0045892 [negative regulation of transcription, DNA-templated]
GO:0045893 [positive regulation of transcription, DNA-templated]
GO:0060849 [regulation of transcription involved in lymphatic endothelial cell fate commitment]
Show all
 261 aa
29.2 kDa 		No 0
NR2F2-004
ENSP00000457112
ENST00000559679
H3BTC2 [Direct mapping]
COUP transcription factor 2
Show all
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0003677 [DNA binding]
GO:0003707 [steroid hormone receptor activity]
GO:0004879 [RNA polymerase II transcription factor activity, ligand-activated sequence-specific DNA binding]
GO:0005634 [nucleus]
GO:0006351 [transcription, DNA-templated]
GO:0006355 [regulation of transcription, DNA-templated]
GO:0030522 [intracellular receptor signaling pathway]
GO:0043401 [steroid hormone mediated signaling pathway]
Show all
 93 aa
10.4 kDa 		No 0
NR2F2-201
ENSP00000377726
ENST00000394171
P24468 [Direct mapping]
COUP transcription factor 2
Show all
Nuclear receptors
Predicted intracellular proteins
Transcription factors
   Zinc-coordinating DNA-binding domains
Disease related genes
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000122 [negative regulation of transcription from RNA polymerase II promoter]
GO:0001937 [negative regulation of endothelial cell proliferation]
GO:0001972 [retinoic acid binding]
GO:0003700 [transcription factor activity, sequence-specific DNA binding]
GO:0003707 [steroid hormone receptor activity]
GO:0003714 [transcription corepressor activity]
GO:0004879 [RNA polymerase II transcription factor activity, ligand-activated sequence-specific DNA binding]
GO:0005515 [protein binding]
GO:0005634 [nucleus]
GO:0006351 [transcription, DNA-templated]
GO:0006355 [regulation of transcription, DNA-templated]
GO:0006357 [regulation of transcription from RNA polymerase II promoter]
GO:0006629 [lipid metabolic process]
GO:0007165 [signal transduction]
GO:0008270 [zinc ion binding]
GO:0010596 [negative regulation of endothelial cell migration]
GO:0030522 [intracellular receptor signaling pathway]
GO:0042803 [protein homodimerization activity]
GO:0043401 [steroid hormone mediated signaling pathway]
GO:0043565 [sequence-specific DNA binding]
GO:0045736 [negative regulation of cyclin-dependent protein serine/threonine kinase activity]
GO:0045892 [negative regulation of transcription, DNA-templated]
GO:0045893 [positive regulation of transcription, DNA-templated]
GO:0060849 [regulation of transcription involved in lymphatic endothelial cell fate commitment]
Show all
 261 aa
29.2 kDa 		No 0

Contact

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.