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NR2F2

GENERAL INFORMATION

Gene name

 NR2F2

Gene description

 Nuclear receptor subfamily 2, group F, member 2

Protein class

 Disease related genes
Nuclear receptors
Predicted intracellular proteins
Transcription factors

Predicted localization

 Intracellular

Number of transcripts

 5
SHOW MORE

HUMAN PROTEIN ATLAS INFORMATION

RNA tissue category
HPA:Tissue enhanced (ovary)
GTEx:Expressed in all
FANTOM5:Expressed in all

Protein evidence

 Evidence at protein level

DATA RELIABILITY

Reliability score

 Pending normal tissue annotation.

RNA AND PROTEIN EXPRESSION SUMMARY
RNA expression (TPM) Protein expression (score)
Brain
N/A
Hippocampus
N/A
N/A
Caudate
N/A
N/A
Cerebellum
N/A
N/A
Endocrine tissues
N/A
Bone marrow & immune system
N/A
Appendix
N/A
Tonsil
N/A
Spleen
N/A
Muscle tissues
N/A
Lung
N/A
Nasopharynx
N/A
N/A
Bronchus
N/A
N/A
Lung
N/A
Liver & gallbladder
N/A
Liver
N/A
Pancreas
N/A
Pancreas
N/A
Gastrointestinal tract
N/A
Oral mucosa
N/A
N/A
Esophagus
N/A
Stomach
N/A
Duodenum
N/A
Colon
N/A
Rectum
N/A
Kidney & urinary bladder
N/A
Kidney
N/A
Male tissues
N/A
Testis
N/A
Prostate
N/A
Female tissues
N/A
Breast
N/A
Vagina
N/A
N/A
Ovary
N/A
Placenta
N/A
Adipose & soft tissue
N/A
Soft tissue
N/A
N/A
Skin
N/A
Skin
N/A

PROTEIN EXPRESSION OVERVIEW
Pending normal tissue annotation.

RNA EXPRESSION OVERVIEW
HPA dataset
Organ
Expression
Alphabetical
RNA tissue category: Tissue enhanced (ovary)
GTEx dataset
Organ
Expression
Alphabetical
RNA tissue category: Expressed in all
FANTOM5 dataset
Organ
Expression
Alphabetical
RNA tissue category: Expressed in all

GENE INFORMATION

Gene name

 NR2F2 (HGNC Symbol)

Synonyms

 ARP1, COUP-TFII, COUPTFB, NF-E3, SVP40, TFCOUP2

Description

 Nuclear receptor subfamily 2, group F, member 2 (HGNC Symbol)

Entrez gene summary

 This gene encodes a member of the steroid thyroid hormone superfamily of nuclear receptors. The encoded protein is a ligand inducible transcription factor that is involved in the regulation of many different genes. Alternate splicing results in multiple transcript variants. [provided by RefSeq, Mar 2010]

Chromosome

 15

Cytoband

 q26.2

Chromosome location (bp)

 96325938 - 96340263

Protein evidence

 Evidence at protein level (all genes)

Ensembl

 ENSG00000185551 (version 83.38)

Entrez gene

 7026

UniProt

 P24468 (UniProt - Evidence at protein level)

neXtProt

 NX_P24468

Antibodypedia

 NR2F2 antibodies

PROTEIN BROWSER
NR2F2-001
NR2F2-002
NR2F2-003
NR2F2-004
NR2F2-201

PROTEIN INFORMATION

Splice variant

UniProt

Protein class

Gene ontology

Length & mass

Signal peptide
(predicted)

Transmembrane regions
(predicted)
NR2F2-001
ENSP00000377721
ENST00000394166
P24468 [Direct mapping]
COUP transcription factor 2
F1D8R0 [Target identity:100%; Query identity:100%]
Nuclear receptor subfamily 2, group F, member 2, isoform CRA_a; Ovalbumin upstream promoter-transcription factor II variant 1
Show all
Nuclear receptors
Predicted intracellular proteins
Transcription factors
   Zinc-coordinating DNA-binding domains
Disease related genes
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000122 [negative regulation of transcription from RNA polymerase II promoter]
GO:0001701 [in utero embryonic development]
GO:0001764 [neuron migration]
GO:0001893 [maternal placenta development]
GO:0001937 [negative regulation of endothelial cell proliferation]
GO:0001945 [lymph vessel development]
GO:0001972 [retinoic acid binding]
GO:0003677 [DNA binding]
GO:0003700 [transcription factor activity, sequence-specific DNA binding]
GO:0003707 [steroid hormone receptor activity]
GO:0003714 [transcription corepressor activity]
GO:0004879 [RNA polymerase II transcription factor activity, ligand-activated sequence-specific DNA binding]
GO:0005515 [protein binding]
GO:0005634 [nucleus]
GO:0006351 [transcription, DNA-templated]
GO:0006355 [regulation of transcription, DNA-templated]
GO:0006357 [regulation of transcription from RNA polymerase II promoter]
GO:0006629 [lipid metabolic process]
GO:0007165 [signal transduction]
GO:0007519 [skeletal muscle tissue development]
GO:0008270 [zinc ion binding]
GO:0009566 [fertilization]
GO:0009952 [anterior/posterior pattern specification]
GO:0009956 [radial pattern formation]
GO:0010596 [negative regulation of endothelial cell migration]
GO:0030522 [intracellular receptor signaling pathway]
GO:0030900 [forebrain development]
GO:0032355 [response to estradiol]
GO:0042803 [protein homodimerization activity]
GO:0043401 [steroid hormone mediated signaling pathway]
GO:0043565 [sequence-specific DNA binding]
GO:0045736 [negative regulation of cyclin-dependent protein serine/threonine kinase activity]
GO:0045892 [negative regulation of transcription, DNA-templated]
GO:0045893 [positive regulation of transcription, DNA-templated]
GO:0048514 [blood vessel morphogenesis]
GO:0060173 [limb development]
GO:0060674 [placenta blood vessel development]
GO:0060707 [trophoblast giant cell differentiation]
GO:0060849 [regulation of transcription involved in lymphatic endothelial cell fate commitment]
Show all
 414 aa
45.6 kDa 		No 0
NR2F2-002
ENSP00000401674
ENST00000421109
P24468 [Direct mapping]
COUP transcription factor 2
Show all
Nuclear receptors
Predicted intracellular proteins
Transcription factors
   Zinc-coordinating DNA-binding domains
Disease related genes
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000122 [negative regulation of transcription from RNA polymerase II promoter]
GO:0001937 [negative regulation of endothelial cell proliferation]
GO:0001972 [retinoic acid binding]
GO:0003700 [transcription factor activity, sequence-specific DNA binding]
GO:0003707 [steroid hormone receptor activity]
GO:0003714 [transcription corepressor activity]
GO:0004879 [RNA polymerase II transcription factor activity, ligand-activated sequence-specific DNA binding]
GO:0005515 [protein binding]
GO:0005634 [nucleus]
GO:0006351 [transcription, DNA-templated]
GO:0006355 [regulation of transcription, DNA-templated]
GO:0006357 [regulation of transcription from RNA polymerase II promoter]
GO:0006629 [lipid metabolic process]
GO:0007165 [signal transduction]
GO:0008270 [zinc ion binding]
GO:0010596 [negative regulation of endothelial cell migration]
GO:0030522 [intracellular receptor signaling pathway]
GO:0042803 [protein homodimerization activity]
GO:0043401 [steroid hormone mediated signaling pathway]
GO:0043565 [sequence-specific DNA binding]
GO:0045736 [negative regulation of cyclin-dependent protein serine/threonine kinase activity]
GO:0045892 [negative regulation of transcription, DNA-templated]
GO:0045893 [positive regulation of transcription, DNA-templated]
GO:0060849 [regulation of transcription involved in lymphatic endothelial cell fate commitment]
Show all
 281 aa
31.5 kDa 		No 0
NR2F2-003
ENSP00000389853
ENST00000453270
P24468 [Direct mapping]
COUP transcription factor 2
Show all
Nuclear receptors
Predicted intracellular proteins
Transcription factors
   Zinc-coordinating DNA-binding domains
Disease related genes
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000122 [negative regulation of transcription from RNA polymerase II promoter]
GO:0001937 [negative regulation of endothelial cell proliferation]
GO:0001972 [retinoic acid binding]
GO:0003700 [transcription factor activity, sequence-specific DNA binding]
GO:0003707 [steroid hormone receptor activity]
GO:0003714 [transcription corepressor activity]
GO:0004879 [RNA polymerase II transcription factor activity, ligand-activated sequence-specific DNA binding]
GO:0005515 [protein binding]
GO:0005634 [nucleus]
GO:0006351 [transcription, DNA-templated]
GO:0006355 [regulation of transcription, DNA-templated]
GO:0006357 [regulation of transcription from RNA polymerase II promoter]
GO:0006629 [lipid metabolic process]
GO:0007165 [signal transduction]
GO:0008270 [zinc ion binding]
GO:0010596 [negative regulation of endothelial cell migration]
GO:0030522 [intracellular receptor signaling pathway]
GO:0042803 [protein homodimerization activity]
GO:0043401 [steroid hormone mediated signaling pathway]
GO:0043565 [sequence-specific DNA binding]
GO:0045736 [negative regulation of cyclin-dependent protein serine/threonine kinase activity]
GO:0045892 [negative regulation of transcription, DNA-templated]
GO:0045893 [positive regulation of transcription, DNA-templated]
GO:0060849 [regulation of transcription involved in lymphatic endothelial cell fate commitment]
Show all
 261 aa
29.2 kDa 		No 0
NR2F2-004
ENSP00000457112
ENST00000559679
H3BTC2 [Direct mapping]
COUP transcription factor 2
Show all
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0003677 [DNA binding]
GO:0003707 [steroid hormone receptor activity]
GO:0004879 [RNA polymerase II transcription factor activity, ligand-activated sequence-specific DNA binding]
GO:0005634 [nucleus]
GO:0006351 [transcription, DNA-templated]
GO:0006355 [regulation of transcription, DNA-templated]
GO:0030522 [intracellular receptor signaling pathway]
GO:0043401 [steroid hormone mediated signaling pathway]
Show all
 93 aa
10.4 kDa 		No 0
NR2F2-201
ENSP00000377726
ENST00000394171
P24468 [Direct mapping]
COUP transcription factor 2
Show all
Nuclear receptors
Predicted intracellular proteins
Transcription factors
   Zinc-coordinating DNA-binding domains
Disease related genes
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000122 [negative regulation of transcription from RNA polymerase II promoter]
GO:0001937 [negative regulation of endothelial cell proliferation]
GO:0001972 [retinoic acid binding]
GO:0003700 [transcription factor activity, sequence-specific DNA binding]
GO:0003707 [steroid hormone receptor activity]
GO:0003714 [transcription corepressor activity]
GO:0004879 [RNA polymerase II transcription factor activity, ligand-activated sequence-specific DNA binding]
GO:0005515 [protein binding]
GO:0005634 [nucleus]
GO:0006351 [transcription, DNA-templated]
GO:0006355 [regulation of transcription, DNA-templated]
GO:0006357 [regulation of transcription from RNA polymerase II promoter]
GO:0006629 [lipid metabolic process]
GO:0007165 [signal transduction]
GO:0008270 [zinc ion binding]
GO:0010596 [negative regulation of endothelial cell migration]
GO:0030522 [intracellular receptor signaling pathway]
GO:0042803 [protein homodimerization activity]
GO:0043401 [steroid hormone mediated signaling pathway]
GO:0043565 [sequence-specific DNA binding]
GO:0045736 [negative regulation of cyclin-dependent protein serine/threonine kinase activity]
GO:0045892 [negative regulation of transcription, DNA-templated]
GO:0045893 [positive regulation of transcription, DNA-templated]
GO:0060849 [regulation of transcription involved in lymphatic endothelial cell fate commitment]
Show all
 261 aa
29.2 kDa 		No 0

Contact

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.