Cell atlas - AHNAK2 - The Human Protein Atlas

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AHNAK2

TISSUE

CELL

PATHOLOGY

CELL ATLAS RNA EXPRESSION HUMAN CELLS CUSTOM DATA

GENE/PROTEIN

Antibody validation

Dictionary
	Cytosol
	Plasma membrane

Human cell
	Cytosol
	Plasma Membrane

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GENERAL INFORMATION
Gene name	AHNAK2
Gene description	AHNAK nucleoprotein 2
Protein class	Cancer-related genes Predicted intracellular proteins
Predicted localization	Intracellular
Number of transcripts	2
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HUMAN PROTEIN ATLAS INFORMATION
Summary	Mainly localized to the cytosol. In addition localized to the plasma membrane.
RNA cell category	Cell line enhanced (hTCEpi, TIME)
Protein evidence	Evidence at protein level
Main location	Localized to the Cytosol (validated)
Additional location	In addition localized to the Plasma membrane (validated)
Single-cell variation	Single-cell variation in protein expression observed.
Cell cycle dependency	Cell cycle dependent expression determined by custom assay

DATA RELIABILITY
Reliability score	Validated based on 2 antibodies. HPA002940 , HPA004145
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ASSAYS

RNA expression

Human cells

Custom data

RNA EXPRESSION OVERVIEW
RNA cell line category: Cell line enhanced (hTCEpi, TIME) Organ Origin Category Expression Alphabetical Cell lines sorted after organ of phenotypic resemblance. Cell lines sorted after biological source for establishment. Cell lines sorted after the cell line category according to Cellosaurus. Cell lines sorted on descending RNA expression. Cell lines sorted alphabetically.

HUMAN CELLS

Summary

Mainly localized to the cytosol. In addition localized to the plasma membrane.

Main location

Cytosol (validated)

Additional location

Plasma membrane (validated)


	Toggle channels	Low High G1 S G2 M N/A

Antibody	Cell line	Location	Single-cell variation	Cell cycle dependent variation
HPA002940	A-431	Cytosol	Intensity
HPA002940	U-2 OS	Plasma membrane	Intensity	Intensity
HPA002940	U-2 OS	Cytosol	Intensity	Intensity
HPA002940	U-251 MG	Cytosol
HPA004145	A-431	Cytosol
HPA004145	U-2 OS	Plasma membrane	Intensity	Intensity
HPA004145	U-2 OS	Cytosol	Intensity	Intensity
HPA004145	U-251 MG	Cytosol	Intensity

CUSTOM DATA


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Thumbnail	Antibody	Cell line	Assay	Description
	HPA002940	U-2 OS	Image	Staining of U-2 OS FUCCI cells, to characterize the cell cycle dependency of the protein expression pattern. The FUCCI cells, Fluorescence Ubiquitination Cell Cycle Indicator, are cells tagged with different fluorescent proteins fused to two different cell cycle regulators Cdt1 (expressed in G1 phase) and Geminin (expressed in S and G2 phases) that allows cell cycle monitoring. When both proteins are present, the overlay of the images appear in yellow marking the G1/S transition. AHNAK2 is mostly expressed during G1, during S and/or G2, and during Mitosis.
	HPA004145	U-2 OS	Image	Staining of U-2 OS FUCCI cells, to characterize the cell cycle dependency of the protein expression pattern. The FUCCI cells, Fluorescence Ubiquitination Cell Cycle Indicator, are cells tagged with different fluorescent proteins fused to two different cell cycle regulators Cdt1 (expressed in G1 phase) and Geminin (expressed in S and G2 phases) that allows cell cycle monitoring. When both proteins are present, the overlay of the images appear in yellow marking the G1/S transition. AHNAK2 is mostly expressed during G1, during S and/or G2, and during Mitosis.

CELL CYCLE
Summary	Expression has cell cycle dependency according to custom assay
Intensity variation	Cytosol, Plasma membrane

GENE INFORMATION
Gene name	AHNAK2 (HGNC Symbol)
Synonyms	C14orf78
Description	AHNAK nucleoprotein 2 (HGNC Symbol)
Entrez gene summary
Chromosome	14
Cytoband	q32.33
Chromosome location (bp)	104937244 - 104978357
Protein evidence	Evidence at protein level (all genes)
Ensembl	ENSG00000185567 (version 83.38)
Entrez gene	113146
UniProt	Q8IVF2 (UniProt - Evidence at protein level)
neXtProt	NX_Q8IVF2
Antibodypedia	AHNAK2 antibodies

PROTEIN BROWSER

AHNAK2-001	AHNAK2-003

PROTEIN INFORMATION
Splice variant	UniProt	Protein class	Gene ontology	Length & mass	Signal peptide (predicted)	Transmembrane regions (predicted)
AHNAK2-001 ENSP00000353114 ENST00000333244	Q8IVF2 [Direct mapping] Protein AHNAK2 Show all	Predicted intracellular proteins Cancer-related genes Mutational cancer driver genes Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0005515 [protein binding] GO:0005634 [nucleus] GO:0005737 [cytoplasm] GO:0005886 [plasma membrane] GO:0030018 [Z disc] GO:0030315 [T-tubule] GO:0030659 [cytoplasmic vesicle membrane] GO:0042383 [sarcolemma] GO:0043034 [costamere] Show all	5795 aa 616.6 kDa	No	0
AHNAK2-003 ENSP00000450998 ENST00000557457	Q8IVF2 [Direct mapping] Protein AHNAK2 Show all	Predicted intracellular proteins Cancer-related genes Mutational cancer driver genes Protein evidence (Ezkurdia et al 2014) Show all	GO:0005515 [protein binding] GO:0005634 [nucleus] GO:0005737 [cytoplasm] GO:0005886 [plasma membrane] GO:0030018 [Z disc] GO:0030315 [T-tubule] GO:0030659 [cytoplasmic vesicle membrane] GO:0042383 [sarcolemma] GO:0043034 [costamere] Show all	793 aa 85.1 kDa	No	0

Contact

contact@proteinatlas.org

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.