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Field

Term
Gene name

Class

Subclass

Chromosome

External id

In atlas

Reliability

Reliability

Reliability

Validation

Method

Validation

Method

Validation

Method

Validation

Location

Searches

Tissue

Cell type

Expression

Tissue

Specificity

Cell line

Specificity

Cancer

Specificity

Tissue

Detectable

Cell line

Detectable

Cancer

Detectable

Cancer

Prognosis

Category

Score

Score

Score

Antibodies

Column

 
 
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AHNAK2
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    TISSUE

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    CELL

  • PATHOLOGY

PATHOLOGY ATLAS

GENE/PROTEIN

Antibody validation

Dictionary

Level of antibody staining/expression





High
Medium
Low
Not detected

GENERAL INFORMATION

Gene name

AHNAK2

Gene description

AHNAK nucleoprotein 2

Protein class

Cancer-related genes
Predicted intracellular proteins

Predicted localization

Intracellular

Number of transcripts

2
SHOW MORE

HUMAN PROTEIN ATLAS INFORMATION

RNA category

TCGA (cancer tissue):Mixed
HPA (cell line):Cell line enhanced (hTCEpi, TIME)
HPA (normal tissue):Tissue enriched (skin)

Protein evidence

Evidence at protein level

Protein expression
normal tissue

Distinct cytoplasmic expression in squamous epithelia, respiratory epithelia, smooth muscle and neuropil.

ANTIBODY IHC RELIABILITY

Data reliability
description

Antibody staining mainly consistent with RNA expression data.

Reliability score

Supported based on 4 antibodies.
HPA000878 , HPA002940 , HPA004145 , HPA020111
SHOW MORE

PROGNOSTIC SUMMARY

Prognostic marker in pancreatic cancer (unfavourable), urothelial cancer (unfavourable) and lung cancer (unfavourable).
Pancreatic cancer p<0.001
Urothelial cancer p<0.001
Lung cancer p<0.001
Show all

RNA EXPRESSION OVERVIEW

TCGA dataset
RNA cancer category: Mixed

PROTEIN EXPRESSION

Colorectal cancer
Breast cancer
Prostate cancer
Lung cancer
Skin cancer

STAINING SUMMARY

HPA000878
HPA002940
HPA004145
HPA020111

Cancer

Cancer staining

Protein
expression of
normal tissue

Breast cancer
 
Carcinoid
 
Cervical cancer
 
 
Colorectal cancer
 
 
Endometrial cancer
 
 
Glioma
 
Head and neck cancer
 
 
Liver cancer
 
 
Lung cancer
 
 
Lymphoma
 
 
 

Cancer

Cancer staining

Protein
expression of
normal tissue

Melanoma
 
Ovarian cancer
 
Pancreatic cancer
 
Prostate cancer
 
Renal cancer
 
Skin cancer
 
Stomach cancer
 
 
Testis cancer
 
Thyroid cancer
 
Urothelial cancer
 

Staining summary

Most squamous cell carcinomas, pancreatic and renal cancers as well as cases of cholangiocarcinomas, ovarian and urothelial carcinomas were distinctly stained. Remaining malignancies were generally negative.

Cancer

Cancer staining

Protein
expression of
normal tissue

Breast cancer
 
Carcinoid
 
Cervical cancer
 
 
Colorectal cancer
 
 
Endometrial cancer
 
 
Glioma
 
Head and neck cancer
 
 
Liver cancer
 
 
Lung cancer
 
 
Lymphoma
 
 
 

Cancer

Cancer staining

Protein
expression of
normal tissue

Melanoma
 
Ovarian cancer
 
Pancreatic cancer
 
Prostate cancer
 
Renal cancer
 
Skin cancer
 
Stomach cancer
 
 
Testis cancer
 
Thyroid cancer
 
Urothelial cancer
 

Staining summary

Squamous and urothelial carcinomas, melanomas and gliomas showed strong cytoplasmic positivity, while adenocarcinomas displayed a variable staining pattern.

Cancer

Cancer staining

Protein
expression of
normal tissue

Breast cancer
 
Carcinoid
 
Cervical cancer
 
 
Colorectal cancer
 
 
Endometrial cancer
 
 
Glioma
 
Head and neck cancer
 
 
Liver cancer
 
 
Lung cancer
 
 
Lymphoma
 
 
 

Cancer

Cancer staining

Protein
expression of
normal tissue

Melanoma
 
Ovarian cancer
 
Pancreatic cancer
 
Prostate cancer
 
Renal cancer
 
Skin cancer
 
Stomach cancer
 
 
Testis cancer
 
Thyroid cancer
 
Urothelial cancer
 

Staining summary

Malignant tissues generally displayed moderate to strong cytoplasmic and membranous immunoreactivity, often accompanied with nuclear staining.

Cancer

Cancer staining

Protein
expression of
normal tissue

Breast cancer
 
Carcinoid
 
Cervical cancer
 
 
Colorectal cancer
 
 
Endometrial cancer
 
 
Glioma
 
Head and neck cancer
 
 
Liver cancer
 
 
Lung cancer
 
 
Lymphoma
 
 
 

Cancer

Cancer staining

Protein
expression of
normal tissue

Melanoma
 
Ovarian cancer
 
Pancreatic cancer
 
Prostate cancer
 
Renal cancer
 
Skin cancer
 
Stomach cancer
 
 
Testis cancer
 
Thyroid cancer
 
Urothelial cancer
 

Staining summary

A majority of squamous cell carcinomas, cholangiocarcinomas and melanomas along with several cases of ovarian, endometrial, urothelial, renal and pancreatic cancers displayed moderate to strong cytoplasmic immunoreactivity. Most of the remaining cancer tissues were negative.

GENE INFORMATION

Gene name

AHNAK2 (HGNC Symbol)

Synonyms

C14orf78

Description

AHNAK nucleoprotein 2 (HGNC Symbol)

Entrez gene summary

Chromosome

14

Cytoband

q32.33

Chromosome location (bp)

104937244 - 104978357

Protein evidence

Evidence at protein level (all genes)

Ensembl

ENSG00000185567 (version 83.38)

Entrez gene

113146

UniProt

Q8IVF2 (UniProt - Evidence at protein level)

neXtProt

NX_Q8IVF2

Antibodypedia

AHNAK2 antibodies

PROTEIN BROWSER

AHNAK2-001
AHNAK2-003

PROTEIN INFORMATION

Splice variant

UniProt

Protein class

Gene ontology

Length & mass

Signal peptide
(predicted)

Transmembrane regions
(predicted)

AHNAK2-001
ENSP00000353114
ENST00000333244
Q8IVF2 [Direct mapping]
Protein AHNAK2
Show all
Predicted intracellular proteins
Cancer-related genes
   Mutational cancer driver genes
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0005515 [protein binding]
GO:0005634 [nucleus]
GO:0005737 [cytoplasm]
GO:0005886 [plasma membrane]
GO:0030018 [Z disc]
GO:0030315 [T-tubule]
GO:0030659 [cytoplasmic vesicle membrane]
GO:0042383 [sarcolemma]
GO:0043034 [costamere]
Show all
5795 aa
616.6 kDa
No 0
AHNAK2-003
ENSP00000450998
ENST00000557457
Q8IVF2 [Direct mapping]
Protein AHNAK2
Show all
Predicted intracellular proteins
Cancer-related genes
   Mutational cancer driver genes
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0005515 [protein binding]
GO:0005634 [nucleus]
GO:0005737 [cytoplasm]
GO:0005886 [plasma membrane]
GO:0030018 [Z disc]
GO:0030315 [T-tubule]
GO:0030659 [cytoplasmic vesicle membrane]
GO:0042383 [sarcolemma]
GO:0043034 [costamere]
Show all
793 aa
85.1 kDa
No 0

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