Expression of AHNAK2 in cancer - Summary

GENERAL INFORMATION
Gene name	AHNAK2
Gene description	AHNAK nucleoprotein 2
Protein class	Cancer-related genes Predicted intracellular proteins
Predicted localization	Intracellular
Number of transcripts	2
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HUMAN PROTEIN ATLAS INFORMATION

RNA category

TCGA (cancer tissue):	Mixed
HPA (cell line):	Cell line enhanced (hTCEpi, TIME)
HPA (normal tissue):	Tissue enriched (skin)

Protein evidence

Evidence at protein level

Protein expression
normal tissue

Distinct cytoplasmic expression in squamous epithelia, respiratory epithelia, smooth muscle and neuropil.

ANTIBODY IHC RELIABILITY
Data reliability description	Antibody staining mainly consistent with RNA expression data.
Reliability score	Supported based on 4 antibodies. HPA000878 , HPA002940 , HPA004145 , HPA020111
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PROGNOSTIC SUMMARY
Prognostic marker in pancreatic cancer (unfavourable), urothelial cancer (unfavourable) and lung cancer (unfavourable).
Pancreatic cancer p<0.001 Urothelial cancer p<0.001 Lung cancer p<0.001 Show all

RNA EXPRESSION OVERVIEW
TCGA dataset RNA cancer category: Mixed

PROTEIN EXPRESSION

STAINING SUMMARY

HPA000878	HPA002940	HPA004145	HPA020111

GENE INFORMATION
Gene name	AHNAK2 (HGNC Symbol)
Synonyms	C14orf78
Description	AHNAK nucleoprotein 2 (HGNC Symbol)
Entrez gene summary
Chromosome	14
Cytoband	q32.33
Chromosome location (bp)	104937244 - 104978357
Protein evidence	Evidence at protein level (all genes)
Ensembl	ENSG00000185567 (version 83.38)
Entrez gene	113146
UniProt	Q8IVF2 (UniProt - Evidence at protein level)
neXtProt	NX_Q8IVF2
Antibodypedia	AHNAK2 antibodies

PROTEIN BROWSER

AHNAK2-001	AHNAK2-003

PROTEIN INFORMATION
Splice variant	UniProt	Protein class	Gene ontology	Length & mass	Signal peptide (predicted)	Transmembrane regions (predicted)
AHNAK2-001 ENSP00000353114 ENST00000333244	Q8IVF2 [Direct mapping] Protein AHNAK2 Show all	Predicted intracellular proteins Cancer-related genes Mutational cancer driver genes Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0005515 [protein binding] GO:0005634 [nucleus] GO:0005737 [cytoplasm] GO:0005886 [plasma membrane] GO:0030018 [Z disc] GO:0030315 [T-tubule] GO:0030659 [cytoplasmic vesicle membrane] GO:0042383 [sarcolemma] GO:0043034 [costamere] Show all	5795 aa 616.6 kDa	No	0
AHNAK2-003 ENSP00000450998 ENST00000557457	Q8IVF2 [Direct mapping] Protein AHNAK2 Show all	Predicted intracellular proteins Cancer-related genes Mutational cancer driver genes Protein evidence (Ezkurdia et al 2014) Show all	GO:0005515 [protein binding] GO:0005634 [nucleus] GO:0005737 [cytoplasm] GO:0005886 [plasma membrane] GO:0030018 [Z disc] GO:0030315 [T-tubule] GO:0030659 [cytoplasmic vesicle membrane] GO:0042383 [sarcolemma] GO:0043034 [costamere] Show all	793 aa 85.1 kDa	No	0