Fields »
ABOUT
HELP
BLOG
BRWD1

GENERAL INFORMATION

Gene name

 BRWD1

Gene description

 Bromodomain and WD repeat domain containing 1

Protein class

 Plasma proteins
Predicted intracellular proteins

Predicted localization

 Intracellular

Number of transcripts

 6
SHOW MORE

HUMAN PROTEIN ATLAS INFORMATION

RNA category
TCGA (cancer tissue):Expressed in all
HPA (cell line):Expressed in all
HPA (normal tissue):Expressed in all

Protein evidence

 Evidence at protein level

Protein expression
normal tissue

 General cytoplasmic expression.

ANTIBODY IHC RELIABILITY

Data reliability
description

 Antibody staining mainly consistent with RNA expression data.

Reliability score

 Approved based on 4 antibodies.
HPA030943 , HPA030944 , HPA030945 , CAB034184
SHOW MORE

PROGNOSTIC SUMMARY
Gene product is not prognostic.
Show all

RNA EXPRESSION OVERVIEW
TCGA dataset
RNA cancer category: Expressed in all

PROTEIN EXPRESSION
Colorectal cancer
Breast cancer
Prostate cancer
Lung cancer
Testis cancer

STAINING SUMMARY
HPA030943
HPA030944
HPA030945
CAB034184

GENE INFORMATION

Gene name

 BRWD1 (HGNC Symbol)

Synonyms

 C21orf107, DCAF19, FLJ11315, N143, WDR9

Description

 Bromodomain and WD repeat domain containing 1 (HGNC Symbol)

Entrez gene summary

 This gene encodes a member of the WD repeat protein family. WD repeats are minimally conserved regions of approximately 40 amino acids typically bracketed by gly-his and trp-asp (GH-WD) residues which may facilitate formation of heterotrimeric or multiprotein complexes. Members of this family are involved in a variety of cellular processes including cell cycle progression, signal transduction, apoptosis, and gene regulation. This protein contains 2 bromodomains and multiple WD repeats. This gene is located within the Down syndrome region-2 on chromosome 21. Alternative splicing of this gene generates multiple transcript variants encoding distinct isoforms. In mouse, this gene encodes a nuclear protein that has a polyglutamine-containing region that functions as a transcriptional activation domain which may regulate chromatin remodelling and associates with a component of the SWI/SNF chromatin remodelling complex.[provided by RefSeq, Jun 2011]

Chromosome

 21

Cytoband

 q22.2

Chromosome location (bp)

 39184176 - 39321559

Protein evidence

 Evidence at protein level (all genes)

Ensembl

 ENSG00000185658 (version 83.38)

Entrez gene

 54014

UniProt

 Q9NSI6 (UniProt - Evidence at protein level)

neXtProt

 NX_Q9NSI6

Antibodypedia

 BRWD1 antibodies

PROTEIN BROWSER
BRWD1-001
BRWD1-002
BRWD1-004
BRWD1-010
BRWD1-014
BRWD1-016

PROTEIN INFORMATION

Splice variant

UniProt

Protein class

Gene ontology

Length & mass

Signal peptide
(predicted)

Transmembrane regions
(predicted)
BRWD1-001
ENSP00000330753
ENST00000333229
Q9NSI6 [Direct mapping]
Bromodomain and WD repeat-containing protein 1
Show all
Predicted intracellular proteins
Plasma proteins
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0003674 [molecular_function]
GO:0005515 [protein binding]
GO:0005634 [nucleus]
GO:0005730 [nucleolus]
GO:0005737 [cytoplasm]
GO:0006351 [transcription, DNA-templated]
GO:0006357 [regulation of transcription from RNA polymerase II promoter]
GO:0007010 [cytoskeleton organization]
GO:0008360 [regulation of cell shape]
Show all
 2320 aa
262.9 kDa 		No 0
BRWD1-002
ENSP00000344333
ENST00000342449
Q9NSI6 [Direct mapping]
Bromodomain and WD repeat-containing protein 1
Show all
Predicted intracellular proteins
Plasma proteins
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0003674 [molecular_function]
GO:0005515 [protein binding]
GO:0005634 [nucleus]
GO:0005730 [nucleolus]
GO:0005737 [cytoplasm]
GO:0006351 [transcription, DNA-templated]
GO:0006357 [regulation of transcription from RNA polymerase II promoter]
GO:0007010 [cytoskeleton organization]
GO:0008360 [regulation of cell shape]
Show all
 2269 aa
257.2 kDa 		No 0
BRWD1-004
ENSP00000342106
ENST00000341322
Q9NSI6 [Direct mapping]
Bromodomain and WD repeat-containing protein 1
Show all
Predicted intracellular proteins
Plasma proteins
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0003674 [molecular_function]
GO:0005634 [nucleus]
GO:0005730 [nucleolus]
GO:0005737 [cytoplasm]
GO:0006351 [transcription, DNA-templated]
GO:0006357 [regulation of transcription from RNA polymerase II promoter]
GO:0007010 [cytoskeleton organization]
GO:0008360 [regulation of cell shape]
Show all
 120 aa
13.6 kDa 		No 0
BRWD1-010
ENSP00000415066
ENST00000424441
H7C409 [Direct mapping]
Bromodomain and WD repeat-containing protein 1
Show all
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0005515 [protein binding]
GO:0006357 [regulation of transcription from RNA polymerase II promoter]
Show all
 452 aa
51.9 kDa 		No 0
BRWD1-014
ENSP00000389882
ENST00000455867
H0Y463 [Direct mapping]
Bromodomain and WD repeat-containing protein 1
Show all
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0005515 [protein binding]
GO:0006357 [regulation of transcription from RNA polymerase II promoter]
Show all
 548 aa
62.2 kDa 		No 0
BRWD1-016
ENSP00000370178
ENST00000380800
Q9NSI6 [Direct mapping]
Bromodomain and WD repeat-containing protein 1
Show all
Predicted intracellular proteins
Plasma proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0003674 [molecular_function]
GO:0005515 [protein binding]
GO:0005634 [nucleus]
GO:0005730 [nucleolus]
GO:0005737 [cytoplasm]
GO:0006351 [transcription, DNA-templated]
GO:0006357 [regulation of transcription from RNA polymerase II promoter]
GO:0007010 [cytoskeleton organization]
GO:0008360 [regulation of cell shape]
Show all
 2199 aa
249 kDa 		No 0

Contact

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.