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ANKFY1

GENERAL INFORMATION

Gene name

 ANKFY1

Gene description

 Ankyrin repeat and FYVE domain containing 1

Protein class

 Plasma proteins
Predicted intracellular proteins

Predicted localization

 Intracellular

Number of transcripts

 4
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HUMAN PROTEIN ATLAS INFORMATION

RNA category
TCGA (cancer tissue):Expressed in all
HPA (cell line):Expressed in all
HPA (normal tissue):Expressed in all

Protein evidence

 Evidence at protein level

Protein expression
normal tissue

 Cytoplasmic expression in several tissues, highest levels in gastrointestinal tract and neurons in CNS.

ANTIBODY IHC RELIABILITY

Data reliability
description

 Antibody staining mainly consistent with RNA expression data. Presumed off target binding observed and disregarded.

Reliability score

 Approved based on 2 antibodies.
HPA024513 , HPA024522
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PROGNOSTIC SUMMARY
Gene product is not prognostic.
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RNA EXPRESSION OVERVIEW
TCGA dataset
RNA cancer category: Expressed in all

PROTEIN EXPRESSION
Colorectal cancer
Breast cancer
Prostate cancer
Lung cancer
Liver cancer

STAINING SUMMARY
HPA024513
HPA024522

GENE INFORMATION

Gene name

 ANKFY1 (HGNC Symbol)

Synonyms

 ANKHZN, BTBD23, KIAA1255, RANK-5, ZFYVE14

Description

 Ankyrin repeat and FYVE domain containing 1 (HGNC Symbol)

Entrez gene summary

 This gene encodes a cytoplasmic protein that contains a coiled-coil structure and a BTB/POZ domain at its N-terminus, ankyrin repeats in the middle portion, and a FYVE-finger motif at its C-terminus. This protein belongs to a subgroup of double zinc finger proteins which may be involved in vesicle or protein transport. Alternate splicing results in multiple transcript variants of this gene. [provided by RefSeq, Apr 2012]

Chromosome

 17

Cytoband

 p13.2

Chromosome location (bp)

 4163907 - 4263977

Protein evidence

 Evidence at protein level (all genes)

Ensembl

 ENSG00000185722 (version 83.38)

Entrez gene

 51479

UniProt

 Q9P2R3 (UniProt - Evidence at protein level)

neXtProt

 NX_Q9P2R3

Antibodypedia

 ANKFY1 antibodies

PROTEIN BROWSER
ANKFY1-001
ANKFY1-003
ANKFY1-008
ANKFY1-012

PROTEIN INFORMATION

Splice variant

UniProt

Protein class

Gene ontology

Length & mass

Signal peptide
(predicted)

Transmembrane regions
(predicted)
ANKFY1-001
ENSP00000459943
ENST00000570535
Q9P2R3 [Direct mapping]
Rabankyrin-5
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Predicted intracellular proteins
Plasma proteins
Protein evidence (Ezkurdia et al 2014)
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GO:0005515 [protein binding]
GO:0005765 [lysosomal membrane]
GO:0005769 [early endosome]
GO:0006897 [endocytosis]
GO:0010008 [endosome membrane]
GO:0016020 [membrane]
GO:0017137 [Rab GTPase binding]
GO:0030904 [retromer complex]
GO:0032439 [endosome localization]
GO:0034058 [endosomal vesicle fusion]
GO:0042147 [retrograde transport, endosome to Golgi]
GO:0044354 [macropinosome]
GO:0046872 [metal ion binding]
GO:0048549 [positive regulation of pinocytosis]
GO:0070062 [extracellular exosome]
GO:0090160 [Golgi to lysosome transport]
GO:1901981 [phosphatidylinositol phosphate binding]
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 1211 aa
132.8 kDa 		No 0
ANKFY1-003
ENSP00000459775
ENST00000574367
Q9P2R3 [Direct mapping]
Rabankyrin-5
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Predicted intracellular proteins
Plasma proteins
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0005515 [protein binding]
GO:0005765 [lysosomal membrane]
GO:0005769 [early endosome]
GO:0006897 [endocytosis]
GO:0010008 [endosome membrane]
GO:0016020 [membrane]
GO:0017137 [Rab GTPase binding]
GO:0030904 [retromer complex]
GO:0032439 [endosome localization]
GO:0034058 [endosomal vesicle fusion]
GO:0042147 [retrograde transport, endosome to Golgi]
GO:0044354 [macropinosome]
GO:0046872 [metal ion binding]
GO:0048549 [positive regulation of pinocytosis]
GO:0070062 [extracellular exosome]
GO:0090160 [Golgi to lysosome transport]
GO:1901981 [phosphatidylinositol phosphate binding]
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 1170 aa
128.5 kDa 		No 0
ANKFY1-008
ENSP00000343362
ENST00000341657
Q9P2R3 [Direct mapping]
Rabankyrin-5
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Predicted intracellular proteins
Plasma proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0005515 [protein binding]
GO:0005765 [lysosomal membrane]
GO:0005769 [early endosome]
GO:0006897 [endocytosis]
GO:0010008 [endosome membrane]
GO:0016020 [membrane]
GO:0017137 [Rab GTPase binding]
GO:0030904 [retromer complex]
GO:0032439 [endosome localization]
GO:0034058 [endosomal vesicle fusion]
GO:0042147 [retrograde transport, endosome to Golgi]
GO:0044354 [macropinosome]
GO:0046872 [metal ion binding]
GO:0048549 [positive regulation of pinocytosis]
GO:0070062 [extracellular exosome]
GO:0090160 [Golgi to lysosome transport]
GO:1901981 [phosphatidylinositol phosphate binding]
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 1169 aa
128.4 kDa 		No 0
ANKFY1-012
ENSP00000459247
ENST00000574736
I3L1Z9 [Direct mapping]
Rabankyrin-5
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Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
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 60 aa
6.6 kDa 		No 0

Contact

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.