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IFIT1

GENERAL INFORMATION

Gene name

 IFIT1

Gene description

 Interferon-induced protein with tetratricopeptide repeats 1

Protein class

 Predicted intracellular proteins

Predicted localization

 Intracellular

Number of transcripts

 2
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HUMAN PROTEIN ATLAS INFORMATION

RNA category
TCGA (cancer tissue):Expressed in all
HPA (cell line):Group enriched (BJ hTERT+ SV40 Large T+, BJ hTERT+ SV40 Large T+ RasG12V)
HPA (normal tissue):Expressed in all

Protein evidence

 Evidence at protein level

Protein expression
normal tissue

 Cytoplasmic expression in most tissues.

ANTIBODY IHC RELIABILITY

Data reliability
description

 Antibody staining mainly not consistent with RNA expression data. Pending external verification.

Reliability score

 Approved based on 2 antibodies.
HPA055380 , CAB045980
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PROGNOSTIC SUMMARY
Gene product is not prognostic.
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RNA EXPRESSION OVERVIEW
TCGA dataset
RNA cancer category: Expressed in all

PROTEIN EXPRESSION
Colorectal cancer
Breast cancer
Prostate cancer
Lung cancer

STAINING SUMMARY
HPA055380
CAB045980

GENE INFORMATION

Gene name

 IFIT1 (HGNC Symbol)

Synonyms

 G10P1, GARG-16, IFI56, IFNAI1

Description

 Interferon-induced protein with tetratricopeptide repeats 1 (HGNC Symbol)

Entrez gene summary

 This gene encodes a protein containing tetratricopeptide repeats that was originally identified as induced upon treatment with interferon. The encoded protein may inhibit viral replication and translational initiation. This gene is located in a cluster on chromosome 10 with five other closely related genes. There is a pseudogene for this gene on chromosome 13. Alternatively spliced transcript variants encoding multiple isoforms have been observed. [provided by RefSeq, Aug 2012]

Chromosome

 10

Cytoband

 q23.31

Chromosome location (bp)

 89392546 - 89406486

Protein evidence

 Evidence at protein level (all genes)

Ensembl

 ENSG00000185745 (version 83.38)

Entrez gene

 3434

UniProt

 P09914 (UniProt - Evidence at protein level)

neXtProt

 NX_P09914

Antibodypedia

 IFIT1 antibodies

PROTEIN BROWSER
IFIT1-001
IFIT1-201

PROTEIN INFORMATION

Splice variant

UniProt

Protein class

Gene ontology

Length & mass

Signal peptide
(predicted)

Transmembrane regions
(predicted)
IFIT1-001
ENSP00000360869
ENST00000371804
P09914 [Direct mapping]
Interferon-induced protein with tetratricopeptide repeats 1
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Predicted intracellular proteins
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
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GO:0003723 [RNA binding]
GO:0005515 [protein binding]
GO:0005737 [cytoplasm]
GO:0005829 [cytosol]
GO:0009615 [response to virus]
GO:0019060 [intracellular transport of viral protein in host cell]
GO:0019221 [cytokine-mediated signaling pathway]
GO:0032091 [negative regulation of protein binding]
GO:0043657 [host cell]
GO:0045070 [positive regulation of viral genome replication]
GO:0045071 [negative regulation of viral genome replication]
GO:0050689 [negative regulation of defense response to virus by host]
GO:0051097 [negative regulation of helicase activity]
GO:0051607 [defense response to virus]
GO:0060337 [type I interferon signaling pathway]
GO:0071357 [cellular response to type I interferon]
GO:0071360 [cellular response to exogenous dsRNA]
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 478 aa
55.4 kDa 		No 0
IFIT1-201
ENSP00000441968
ENST00000546318
P09914 [Direct mapping]
Interferon-induced protein with tetratricopeptide repeats 1
Show all
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0003723 [RNA binding]
GO:0005515 [protein binding]
GO:0005737 [cytoplasm]
GO:0005829 [cytosol]
GO:0009615 [response to virus]
GO:0019060 [intracellular transport of viral protein in host cell]
GO:0019221 [cytokine-mediated signaling pathway]
GO:0032091 [negative regulation of protein binding]
GO:0043657 [host cell]
GO:0045070 [positive regulation of viral genome replication]
GO:0045071 [negative regulation of viral genome replication]
GO:0050689 [negative regulation of defense response to virus by host]
GO:0051097 [negative regulation of helicase activity]
GO:0051607 [defense response to virus]
GO:0060337 [type I interferon signaling pathway]
GO:0071357 [cellular response to type I interferon]
GO:0071360 [cellular response to exogenous dsRNA]
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 447 aa
51.7 kDa 		No 0

Contact

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.