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Interferon-induced protein with tetratricopeptide repeats 1 (HGNC Symbol)
Entrez gene summary
This gene encodes a protein containing tetratricopeptide repeats that was originally identified as induced upon treatment with interferon. The encoded protein may inhibit viral replication and translational initiation. This gene is located in a cluster on chromosome 10 with five other closely related genes. There is a pseudogene for this gene on chromosome 13. Alternatively spliced transcript variants encoding multiple isoforms have been observed. [provided by RefSeq, Aug 2012]
P09914 [Direct mapping] Interferon-induced protein with tetratricopeptide repeats 1
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Predicted intracellular proteins Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014)
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GO:0003723 [RNA binding] GO:0005515 [protein binding] GO:0005737 [cytoplasm] GO:0005829 [cytosol] GO:0009615 [response to virus] GO:0019060 [intracellular transport of viral protein in host cell] GO:0019221 [cytokine-mediated signaling pathway] GO:0032091 [negative regulation of protein binding] GO:0043657 [host cell] GO:0045070 [positive regulation of viral genome replication] GO:0045071 [negative regulation of viral genome replication] GO:0050689 [negative regulation of defense response to virus by host] GO:0051097 [negative regulation of helicase activity] GO:0051607 [defense response to virus] GO:0060337 [type I interferon signaling pathway] GO:0071357 [cellular response to type I interferon] GO:0071360 [cellular response to exogenous dsRNA]
P09914 [Direct mapping] Interferon-induced protein with tetratricopeptide repeats 1
Show all
Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014)
Show all
GO:0003723 [RNA binding] GO:0005515 [protein binding] GO:0005737 [cytoplasm] GO:0005829 [cytosol] GO:0009615 [response to virus] GO:0019060 [intracellular transport of viral protein in host cell] GO:0019221 [cytokine-mediated signaling pathway] GO:0032091 [negative regulation of protein binding] GO:0043657 [host cell] GO:0045070 [positive regulation of viral genome replication] GO:0045071 [negative regulation of viral genome replication] GO:0050689 [negative regulation of defense response to virus by host] GO:0051097 [negative regulation of helicase activity] GO:0051607 [defense response to virus] GO:0060337 [type I interferon signaling pathway] GO:0071357 [cellular response to type I interferon] GO:0071360 [cellular response to exogenous dsRNA]
