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BCAP31

GENERAL INFORMATION

Gene name

 BCAP31

Gene description

 B-cell receptor-associated protein 31

Protein class

 Disease related genes
Potential drug targets
Predicted membrane proteins
Transporters

Predicted localization

 Membrane

Number of transcripts

 7
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HUMAN PROTEIN ATLAS INFORMATION

RNA category
TCGA (cancer tissue):Expressed in all
HPA (cell line):Expressed in all
HPA (normal tissue):Expressed in all

Protein evidence

 Evidence at protein level

Protein expression
normal tissue

 Ubiquitous cytoplasmic expression.

ANTIBODY IHC RELIABILITY

Data reliability
description

 Antibody staining mainly consistent with RNA expression data. Presumed off target binding observed and disregarded.

Reliability score

 Supported based on 3 antibodies.
HPA003906 , CAB015350 , CAB015424
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PROGNOSTIC SUMMARY
Prognostic marker in head and neck cancer (unfavourable).
Head and neck cancer p<0.001
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RNA EXPRESSION OVERVIEW
TCGA dataset
RNA cancer category: Expressed in all

PROTEIN EXPRESSION
Colorectal cancer
Breast cancer
Prostate cancer
Lung cancer

STAINING SUMMARY
HPA003906
CAB015350
CAB015424

GENE INFORMATION

Gene name

 BCAP31 (HGNC Symbol)

Synonyms

 6C6-Ag, BAP31, CDM, DXS1357E

Description

 B-cell receptor-associated protein 31 (HGNC Symbol)

Entrez gene summary

 This gene encodes a member of the B-cell receptor associated protein 31 superfamily. The encoded protein is a multi-pass transmembrane protein of the endoplasmic reticulum that is involved in the anterograde transport of membrane proteins from the endoplasmic reticulum to the Golgi and in caspase 8-mediated apoptosis. Microdeletions in this gene are associated with contiguous ABCD1/DXS1375E deletion syndrome (CADDS), a neonatal disorder. Alternative splicing of this gene results in multiple transcript variants. Two related pseudogenes have been identified on chromosome 16. [provided by RefSeq, Jan 2012]

Chromosome

 X

Cytoband

 q28

Chromosome location (bp)

 153700497 - 153724697

Protein evidence

 Evidence at protein level (all genes)

Ensembl

 ENSG00000185825 (version 83.38)

Entrez gene

 10134

UniProt

 P51572 (UniProt - Evidence at protein level)

neXtProt

 NX_P51572

Antibodypedia

 BCAP31 antibodies

PROTEIN BROWSER
BCAP31-001
BCAP31-002
BCAP31-004
BCAP31-005
BCAP31-006
BCAP31-007
BCAP31-009

PROTEIN INFORMATION

Splice variant

UniProt

Protein class

Gene ontology

Length & mass

Signal peptide
(predicted)

Transmembrane regions
(predicted)
BCAP31-001
ENSP00000343458
ENST00000345046
P51572 [Direct mapping]
B-cell receptor-associated protein 31
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Transporters
   Primary Active Transporters
Predicted membrane proteins
   Prediction method-based
   Membrane proteins predicted by MDM
   MEMSAT3 predicted membrane proteins
   MEMSAT-SVM predicted membrane proteins
   Phobius predicted membrane proteins
   SCAMPI predicted membrane proteins
   SPOCTOPUS predicted membrane proteins
   THUMBUP predicted membrane proteins
   TMHMM predicted membrane proteins
   # TM segments-based
   3TM proteins predicted by MDM
Disease related genes
Potential drug targets
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0002474 [antigen processing and presentation of peptide antigen via MHC class I]
GO:0005515 [protein binding]
GO:0005739 [mitochondrion]
GO:0005783 [endoplasmic reticulum]
GO:0005784 [Sec61 translocon complex]
GO:0005789 [endoplasmic reticulum membrane]
GO:0005811 [lipid particle]
GO:0005829 [cytosol]
GO:0005887 [integral component of plasma membrane]
GO:0006886 [intracellular protein transport]
GO:0006915 [apoptotic process]
GO:0006921 [cellular component disassembly involved in execution phase of apoptosis]
GO:0007204 [positive regulation of cytosolic calcium ion concentration]
GO:0012501 [programmed cell death]
GO:0016020 [membrane]
GO:0032471 [negative regulation of endoplasmic reticulum calcium ion concentration]
GO:0033116 [endoplasmic reticulum-Golgi intermediate compartment membrane]
GO:0035584 [calcium-mediated signaling using intracellular calcium source]
GO:0043280 [positive regulation of cysteine-type endopeptidase activity involved in apoptotic process]
GO:0051561 [positive regulation of mitochondrial calcium ion concentration]
GO:0071556 [integral component of lumenal side of endoplasmic reticulum membrane]
GO:1903071 [positive regulation of ER-associated ubiquitin-dependent protein catabolic process]
GO:1904154 [positive regulation of retrograde protein transport, ER to cytosol]
GO:2001244 [positive regulation of intrinsic apoptotic signaling pathway]
Show all
 246 aa
28 kDa 		No 3
BCAP31-002
ENSP00000392330
ENST00000458587
P51572 [Direct mapping]
B-cell receptor-associated protein 31
Show all
Transporters
   Primary Active Transporters
Predicted membrane proteins
   Prediction method-based
   Membrane proteins predicted by MDM
   MEMSAT3 predicted membrane proteins
   MEMSAT-SVM predicted membrane proteins
   Phobius predicted membrane proteins
   SCAMPI predicted membrane proteins
   SPOCTOPUS predicted membrane proteins
   THUMBUP predicted membrane proteins
   TMHMM predicted membrane proteins
   # TM segments-based
   3TM proteins predicted by MDM
Disease related genes
Potential drug targets
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000139 [Golgi membrane]
GO:0002474 [antigen processing and presentation of peptide antigen via MHC class I]
GO:0005515 [protein binding]
GO:0005739 [mitochondrion]
GO:0005783 [endoplasmic reticulum]
GO:0005784 [Sec61 translocon complex]
GO:0005789 [endoplasmic reticulum membrane]
GO:0005811 [lipid particle]
GO:0005829 [cytosol]
GO:0005887 [integral component of plasma membrane]
GO:0006886 [intracellular protein transport]
GO:0006888 [ER to Golgi vesicle-mediated transport]
GO:0006915 [apoptotic process]
GO:0006921 [cellular component disassembly involved in execution phase of apoptosis]
GO:0007204 [positive regulation of cytosolic calcium ion concentration]
GO:0007283 [spermatogenesis]
GO:0012501 [programmed cell death]
GO:0016020 [membrane]
GO:0030136 [clathrin-coated vesicle]
GO:0032403 [protein complex binding]
GO:0032471 [negative regulation of endoplasmic reticulum calcium ion concentration]
GO:0032580 [Golgi cisterna membrane]
GO:0033116 [endoplasmic reticulum-Golgi intermediate compartment membrane]
GO:0035584 [calcium-mediated signaling using intracellular calcium source]
GO:0042288 [MHC class I protein binding]
GO:0043280 [positive regulation of cysteine-type endopeptidase activity involved in apoptotic process]
GO:0051561 [positive regulation of mitochondrial calcium ion concentration]
GO:0070973 [protein localization to endoplasmic reticulum exit site]
GO:0071556 [integral component of lumenal side of endoplasmic reticulum membrane]
GO:1903071 [positive regulation of ER-associated ubiquitin-dependent protein catabolic process]
GO:1904154 [positive regulation of retrograde protein transport, ER to cytosol]
GO:2001244 [positive regulation of intrinsic apoptotic signaling pathway]
Show all
 313 aa
34.8 kDa 		No 3
BCAP31-004
ENSP00000394270
ENST00000416815
C9JSP1 [Direct mapping]
B-cell receptor-associated protein 31
Show all
Predicted membrane proteins
   Prediction method-based
   Membrane proteins predicted by MDM
   MEMSAT3 predicted membrane proteins
   MEMSAT-SVM predicted membrane proteins
   Phobius predicted membrane proteins
   SCAMPI predicted membrane proteins
   SPOCTOPUS predicted membrane proteins
   THUMBUP predicted membrane proteins
   TMHMM predicted membrane proteins
   # TM segments-based
   3TM proteins predicted by MDM
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0005783 [endoplasmic reticulum]
GO:0006886 [intracellular protein transport]
GO:0016021 [integral component of membrane]
Show all
 182 aa
20.7 kDa 		No 3
BCAP31-005
ENSP00000409888
ENST00000429550
C9JQ75 [Direct mapping]
B-cell receptor-associated protein 31
Show all
Predicted membrane proteins
   Prediction method-based
   Membrane proteins predicted by MDM
   MEMSAT3 predicted membrane proteins
   MEMSAT-SVM predicted membrane proteins
   Phobius predicted membrane proteins
   SCAMPI predicted membrane proteins
   SPOCTOPUS predicted membrane proteins
   THUMBUP predicted membrane proteins
   TMHMM predicted membrane proteins
   # TM segments-based
   3TM proteins predicted by MDM
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0005783 [endoplasmic reticulum]
GO:0006886 [intracellular protein transport]
GO:0016021 [integral component of membrane]
Show all
 187 aa
21.2 kDa 		No 3
BCAP31-006
ENSP00000400345
ENST00000442093
C9J0M4 [Direct mapping]
B-cell receptor-associated protein 31
Show all
Predicted membrane proteins
   Prediction method-based
   Membrane proteins predicted by MDM
   MEMSAT3 predicted membrane proteins
   MEMSAT-SVM predicted membrane proteins
   Phobius predicted membrane proteins
   SCAMPI predicted membrane proteins
   SPOCTOPUS predicted membrane proteins
   THUMBUP predicted membrane proteins
   TMHMM predicted membrane proteins
   # TM segments-based
   3TM proteins predicted by MDM
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0005783 [endoplasmic reticulum]
GO:0006886 [intracellular protein transport]
GO:0016021 [integral component of membrane]
Show all
 188 aa
21.3 kDa 		No 3
BCAP31-007
ENSP00000402342
ENST00000430088
C9JM14 [Direct mapping]
B-cell receptor-associated protein 31
Show all
Predicted membrane proteins
   Prediction method-based
   Membrane proteins predicted by MDM
   MEMSAT3 predicted membrane proteins
   MEMSAT-SVM predicted membrane proteins
   Phobius predicted membrane proteins
   SCAMPI predicted membrane proteins
   SPOCTOPUS predicted membrane proteins
   THUMBUP predicted membrane proteins
   TMHMM predicted membrane proteins
   # TM segments-based
   3TM proteins predicted by MDM
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0005783 [endoplasmic reticulum]
GO:0006886 [intracellular protein transport]
GO:0016021 [integral component of membrane]
Show all
 138 aa
16 kDa 		No 3
BCAP31-009
ENSP00000389740
ENST00000423827
C9JMD7 [Direct mapping]
B-cell receptor-associated protein 31
Show all
Predicted membrane proteins
   Prediction method-based
   Membrane proteins predicted by MDM
   MEMSAT3 predicted membrane proteins
   MEMSAT-SVM predicted membrane proteins
   Phobius predicted membrane proteins
   SCAMPI predicted membrane proteins
   SPOCTOPUS predicted membrane proteins
   THUMBUP predicted membrane proteins
   TMHMM predicted membrane proteins
   # TM segments-based
   3TM proteins predicted by MDM
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0005783 [endoplasmic reticulum]
GO:0006886 [intracellular protein transport]
GO:0016021 [integral component of membrane]
Show all
 178 aa
20.2 kDa 		No 3

Contact

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.