Expression of ATP4B in cancer - Summary - The Human Protein Atlas

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ATP4B

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TISSUE

CELL

PATHOLOGY

PATHOLOGY ATLAS

GENE/PROTEIN

Antibody validation

Dictionary


Level of antibody staining/expression
	High Medium Low Not detected

GENERAL INFORMATION
Gene name	ATP4B
Gene description	ATPase, H+/K+ exchanging, beta polypeptide
Protein class	Predicted membrane proteins Transporters
Predicted localization	Membrane
Number of transcripts	1
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HUMAN PROTEIN ATLAS INFORMATION

RNA category

TCGA (cancer tissue):	Tissue enriched (stomach cancer)
HPA (cell line):	Not detected
HPA (normal tissue):	Tissue enriched (stomach)

Protein evidence

Evidence at protein level

Protein expression
normal tissue

Selective cytoplasmic expression in parietal cells.

ANTIBODY IHC RELIABILITY
Data reliability description	Antibody staining consistent with RNA expression data.
Reliability score	Supported based on 2 antibodies. HPA045400 , HPA052649
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PROGNOSTIC SUMMARY
Gene product is not prognostic.
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RNA EXPRESSION OVERVIEW
TCGA dataset RNA cancer category: Tissue enriched (stomach cancer)

PROTEIN EXPRESSION

Colorectal cancer

Prostate cancer

STAINING SUMMARY

HPA045400	HPA052649

GENE INFORMATION
Gene name	ATP4B (HGNC Symbol)
Synonyms	ATP6B
Description	ATPase, H+/K+ exchanging, beta polypeptide (HGNC Symbol)
Entrez gene summary	The protein encoded by this gene belongs to a family of P-type cation-transporting ATPases. The gastric H+, K+-ATPase is a heterodimer consisting of a high molecular weight catalytic alpha subunit and a smaller but heavily glycosylated beta subunit. This enzyme is a proton pump that catalyzes the hydrolysis of ATP coupled with the exchange of H(+) and K(+) ions across the plasma membrane. It is also responsible for gastric acid secretion. This gene encodes the beta subunit of the gastric H+, K+-ATPase. [provided by RefSeq, Jul 2008]
Chromosome	13
Cytoband	q34
Chromosome location (bp)	113648804 - 113658186
Protein evidence	Evidence at protein level (all genes)
Ensembl	ENSG00000186009 (version 83.38)
Entrez gene	496
UniProt	P51164 (UniProt - Evidence at protein level)
neXtProt	NX_P51164
Antibodypedia	ATP4B antibodies

PROTEIN BROWSER

ATP4B-001

PROTEIN INFORMATION
Splice variant	UniProt	Protein class	Gene ontology	Length & mass	Signal peptide (predicted)	Transmembrane regions (predicted)
ATP4B-001 ENSP00000334216 ENST00000335288	P51164 [Direct mapping] Potassium-transporting ATPase subunit beta Show all	Transporters Primary Active Transporters Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based 1TM proteins predicted by MDM Protein evidence (Ezkurdia et al 2014) Show all	GO:0005515 [protein binding] GO:0005886 [plasma membrane] GO:0005890 [sodium:potassium-exchanging ATPase complex] GO:0006813 [potassium ion transport] GO:0006814 [sodium ion transport] GO:0007155 [cell adhesion] GO:0008900 [hydrogen:potassium-exchanging ATPase activity] GO:0010243 [response to organonitrogen compound] GO:0032496 [response to lipopolysaccharide] GO:0034220 [ion transmembrane transport] GO:0055085 [transmembrane transport] GO:1902600 [hydrogen ion transmembrane transport] Show all	291 aa 33.4 kDa	No	1

Contact

contact@proteinatlas.org

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.