Expression of NBPF6 in cancer - Summary - The Human Protein Atlas

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NBPF6

TISSUE

CELL

PATHOLOGY

PATHOLOGY ATLAS

GENE/PROTEIN

Antibody validation

Dictionary


Level of antibody staining/expression
	High Medium Low Not detected

GENERAL INFORMATION
Gene name	NBPF6
Gene description	Neuroblastoma breakpoint family, member 6
Protein class	Predicted intracellular proteins
Predicted localization	Intracellular
Number of transcripts	5
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HUMAN PROTEIN ATLAS INFORMATION

RNA category

TCGA (cancer tissue):	Tissue enriched (breast cancer)
HPA (cell line):	Cell line enhanced (BEWO, K-562)
HPA (normal tissue):	Tissue enriched (testis)

Protein evidence

Evidence at transcript level

Protein expression
normal tissue

RNA-based expert annotation gave inconclusive results.

ANTIBODY IHC RELIABILITY
Data reliability description	Pending external verification. Caution, targets protein from more than one gene. Presumed off target binding observed and disregarded.
Reliability score	Uncertain based on 4 antibodies. HPA045044 , HPA046411 , HPA047447 , HPA058050
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PROGNOSTIC SUMMARY
Gene product is not prognostic.
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RNA EXPRESSION OVERVIEW
TCGA dataset RNA cancer category: Tissue enriched (breast cancer)

PROTEIN EXPRESSION

Colorectal cancer

Prostate cancer

STAINING SUMMARY

HPA045044	HPA046411	HPA047447	HPA058050

GENE INFORMATION
Gene name	NBPF6
Synonyms
Description	Neuroblastoma breakpoint family, member 6 (HGNC Symbol)
Entrez gene summary	This gene is a member of the neuroblastoma breakpoint family (NBPF) which consists of dozens of recently duplicated genes primarily located in segmental duplications on human chromosome 1. This gene family has experienced its greatest expansion within the human lineage and has expanded, to a lesser extent, among primates in general. Members of this gene family are characterized by tandemly repeated copies of DUF1220 protein domains. Gene copy number variations in the human chromosomal region 1q21.1, where most DUF1220 domains are located, have been implicated in a number of developmental and neurogenetic diseases such as microcephaly, macrocephaly, autism, schizophrenia, mental retardation, congenital heart disease, neuroblastoma, and congenital kidney and urinary tract anomalies. Altered expression of some gene family members is associated with several types of cancer. This gene family contains numerous pseudogenes. Alternative splicing of this gene results in multiple transcript variants encoding distinct isoforms. [provided by RefSeq, Mar 2013]
Chromosome	1
Cytoband	p13.3
Chromosome location (bp)	108375799 - 108471002
Protein evidence	Evidence at transcript level (all genes)
Ensembl	ENSG00000186086 (version 83.38)
Entrez gene	653149
UniProt	Q5VWK0 (UniProt - Evidence at transcript level)
neXtProt	NX_Q5VWK0
Antibodypedia	NBPF6 antibodies

PROTEIN BROWSER

NBPF6-002	NBPF6-003	NBPF6-201	NBPF6-202	NBPF6-203

PROTEIN INFORMATION
Splice variant	UniProt	Protein class	Gene ontology	Length & mass	Signal peptide (predicted)	Transmembrane regions (predicted)
NBPF6-002 ENSP00000417277 ENST00000495380	Q5VWK0 [Direct mapping] Neuroblastoma breakpoint family member 6 Show all	Predicted intracellular proteins Show all	GO:0005737 [cytoplasm] Show all	638 aa 72.2 kDa	No	0
NBPF6-003 ENSP00000434735 ENST00000531446	A0A0B4J227 [Direct mapping] Neuroblastoma breakpoint family member 6 Show all	Predicted intracellular proteins Show all		573 aa 64.8 kDa	No	0
NBPF6-201 ENSP00000294652 ENST00000294652	Q5VWK0 [Direct mapping] Neuroblastoma breakpoint family member 6 Show all	Predicted intracellular proteins Show all	GO:0005737 [cytoplasm] Show all	638 aa 72.2 kDa	No	0
NBPF6-202 ENSP00000359057 ENST00000370040	Q5VWK0 [Direct mapping] Neuroblastoma breakpoint family member 6 Show all	Predicted intracellular proteins Show all	GO:0005737 [cytoplasm] Show all	667 aa 75.4 kDa	No	0
NBPF6-203 ENSP00000402703 ENST00000444143	Q5VWK0 [Direct mapping] Neuroblastoma breakpoint family member 6 Show all	Predicted intracellular proteins Show all	GO:0005737 [cytoplasm] Show all	638 aa 72.2 kDa	No	0

Contact

contact@proteinatlas.org

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.