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SLC36A2

GENERAL INFORMATION

Gene name

 SLC36A2

Gene description

 Solute carrier family 36 (proton/amino acid symporter), member 2

Protein class

 Disease related genes
Potential drug targets
Predicted membrane proteins
Transporters

Predicted localization

 Membrane

Number of transcripts

 3
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HUMAN PROTEIN ATLAS INFORMATION

RNA category
TCGA (cancer tissue):Tissue enriched (renal cancer)
HPA (cell line):Not detected
HPA (normal tissue):Group enriched (kidney, skeletal muscle)

Protein evidence

 Evidence at protein level

Protein expression
normal tissue

 Luminal expression in kidney.

ANTIBODY IHC RELIABILITY

Data reliability
description

 Antibody staining mainly consistent with RNA expression data. Presumed off target binding observed and disregarded.

Reliability score

 Supported based on 2 antibodies.
HPA044002 , HPA062229
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PROGNOSTIC SUMMARY
Gene product is not prognostic.
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RNA EXPRESSION OVERVIEW
TCGA dataset
RNA cancer category: Tissue enriched (renal cancer)

PROTEIN EXPRESSION
Colorectal cancer
Breast cancer
Prostate cancer
Lung cancer
Liver cancer

STAINING SUMMARY
HPA044002
HPA062229

GENE INFORMATION

Gene name

 SLC36A2 (HGNC Symbol)

Synonyms

 PAT2, TRAMD1, tramdorin

Description

 Solute carrier family 36 (proton/amino acid symporter), member 2 (HGNC Symbol)

Entrez gene summary

 This gene encodes a pH-dependent proton-coupled amino acid transporter that belongs to the amino acid auxin permease 1 protein family. The encoded protein primarily transports small amino acids such as glycine, alanine and proline. Mutations in this gene are associated with iminoglycinuria and hyperglycinuria. [provided by RefSeq, Sep 2010]

Chromosome

 5

Cytoband

 q33.1

Chromosome location (bp)

 151314978 - 151347590

Protein evidence

 Evidence at protein level (all genes)

Ensembl

 ENSG00000186335 (version 83.38)

Entrez gene

 153201

UniProt

 Q495M3 (UniProt - Evidence at protein level)

neXtProt

 NX_Q495M3

Antibodypedia

 SLC36A2 antibodies

PROTEIN BROWSER
SLC36A2-001
SLC36A2-004
SLC36A2-005

PROTEIN INFORMATION

Splice variant

UniProt

Protein class

Gene ontology

Length & mass

Signal peptide
(predicted)

Transmembrane regions
(predicted)
SLC36A2-001
ENSP00000334223
ENST00000335244
Q495M3 [Direct mapping]
Proton-coupled amino acid transporter 2
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Transporters
   Electrochemical Potential-driven transporters
Predicted membrane proteins
   Prediction method-based
   Membrane proteins predicted by MDM
   MEMSAT3 predicted membrane proteins
   MEMSAT-SVM predicted membrane proteins
   Phobius predicted membrane proteins
   SCAMPI predicted membrane proteins
   SPOCTOPUS predicted membrane proteins
   THUMBUP predicted membrane proteins
   TMHMM predicted membrane proteins
   # TM segments-based
   >9TM proteins predicted by MDM
Disease related genes
Potential drug targets
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
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GO:0005280 [hydrogen:amino acid symporter activity]
GO:0005774 [vacuolar membrane]
GO:0005886 [plasma membrane]
GO:0006811 [ion transport]
GO:0006865 [amino acid transport]
GO:0015078 [hydrogen ion transmembrane transporter activity]
GO:0015180 [L-alanine transmembrane transporter activity]
GO:0015187 [glycine transmembrane transporter activity]
GO:0015193 [L-proline transmembrane transporter activity]
GO:0015808 [L-alanine transport]
GO:0015816 [glycine transport]
GO:0015824 [proline transport]
GO:0015992 [proton transport]
GO:0016021 [integral component of membrane]
GO:0035524 [proline transmembrane transport]
GO:0055085 [transmembrane transport]
GO:0070062 [extracellular exosome]
GO:1902600 [hydrogen ion transmembrane transport]
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 483 aa
53.2 kDa 		No >9
SLC36A2-004
ENSP00000430535
ENST00000521967
E5RJJ5 [Direct mapping]
Proton-coupled amino acid transporter 2
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Predicted membrane proteins
   Prediction method-based
   Membrane proteins predicted by MDM
   MEMSAT3 predicted membrane proteins
   MEMSAT-SVM predicted membrane proteins
   Phobius predicted membrane proteins
   SCAMPI predicted membrane proteins
   SPOCTOPUS predicted membrane proteins
   THUMBUP predicted membrane proteins
   TMHMM predicted membrane proteins
   # TM segments-based
   8TM proteins predicted by MDM
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0005280 [hydrogen:amino acid symporter activity]
GO:0005774 [vacuolar membrane]
GO:0015078 [hydrogen ion transmembrane transporter activity]
GO:0015180 [L-alanine transmembrane transporter activity]
GO:0015193 [L-proline transmembrane transporter activity]
GO:0015808 [L-alanine transport]
GO:0015816 [glycine transport]
GO:0015992 [proton transport]
GO:0016021 [integral component of membrane]
GO:0035524 [proline transmembrane transport]
GO:1902600 [hydrogen ion transmembrane transport]
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 395 aa
43.8 kDa 		No 8
SLC36A2-005
ENSP00000428634
ENST00000523044
H0YB43 [Direct mapping]
Proton-coupled amino acid transporter 2
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Predicted membrane proteins
   Prediction method-based
   Membrane proteins predicted by MDM
   MEMSAT3 predicted membrane proteins
   MEMSAT-SVM predicted membrane proteins
   Phobius predicted membrane proteins
   SCAMPI predicted membrane proteins
   SPOCTOPUS predicted membrane proteins
   THUMBUP predicted membrane proteins
   TMHMM predicted membrane proteins
   # TM segments-based
   2TM proteins predicted by MDM
Protein evidence (Ezkurdia et al 2014)
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GO:0005280 [hydrogen:amino acid symporter activity]
GO:0005774 [vacuolar membrane]
GO:0015078 [hydrogen ion transmembrane transporter activity]
GO:0015180 [L-alanine transmembrane transporter activity]
GO:0015193 [L-proline transmembrane transporter activity]
GO:0015808 [L-alanine transport]
GO:0015816 [glycine transport]
GO:0015992 [proton transport]
GO:0016021 [integral component of membrane]
GO:0035524 [proline transmembrane transport]
GO:1902600 [hydrogen ion transmembrane transport]
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 107 aa
11.4 kDa 		No 2

Contact

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.