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GNG2

GENERAL INFORMATION

Gene name

 GNG2

Gene description

 Guanine nucleotide binding protein (G protein), gamma 2

Protein class

 Predicted intracellular proteins
RAS pathway related proteins

Predicted localization

 Intracellular

Number of transcripts

 10
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HUMAN PROTEIN ATLAS INFORMATION

RNA category
TCGA (cancer tissue):Expressed in all
HPA (cell line):Cell line enhanced (MOLT-4, SH-SY5Y, WM-115)
HPA (normal tissue):Expressed in all

Protein evidence

 Evidence at protein level

Protein expression
normal tissue

 Ubiquitous membranous and cytoplasmic expression.

ANTIBODY IHC RELIABILITY

Data reliability
description

 Antibody staining in cells/structures not annotated, view images. Pending external verification.

Reliability score

 Uncertain based on 2 antibodies.
HPA003534 , CAB018380
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PROGNOSTIC SUMMARY
Prognostic marker in renal cancer (unfavourable) and pancreatic cancer (favourable).
Renal cancer p<0.001
Pancreatic cancer p<0.001
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RNA EXPRESSION OVERVIEW
TCGA dataset
RNA cancer category: Expressed in all

PROTEIN EXPRESSION
Colorectal cancer
Breast cancer
Prostate cancer
Lung cancer
Melanoma

STAINING SUMMARY
HPA003534
CAB018380

GENE INFORMATION

Gene name

 GNG2

Synonyms

Description

 Guanine nucleotide binding protein (G protein), gamma 2 (HGNC Symbol)

Entrez gene summary

 This gene encodes one of the gamma subunits of a guanine nucleotide-binding protein. Such proteins are involved in signaling mechanisms across membranes. Various subunits forms heterodimers which then interact with the different signal molecules. [provided by RefSeq, Aug 2011]

Chromosome

 14

Cytoband

 q22.1

Chromosome location (bp)

 51826195 - 51979342

Protein evidence

 Evidence at protein level (all genes)

Ensembl

 ENSG00000186469 (version 83.38)

Entrez gene

 54331

UniProt

 P59768 (UniProt - Evidence at protein level)

neXtProt

 NX_P59768

Antibodypedia

 GNG2 antibodies

PROTEIN BROWSER
GNG2-001
GNG2-002
GNG2-005
GNG2-006
GNG2-009
GNG2-010
GNG2-012
GNG2-014
GNG2-016
GNG2-201

PROTEIN INFORMATION

Splice variant

UniProt

Protein class

Gene ontology

Length & mass

Signal peptide
(predicted)

Transmembrane regions
(predicted)
GNG2-001
ENSP00000451576
ENST00000556752
P59768 [Direct mapping]
Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2
Show all
Predicted intracellular proteins
RAS pathway related proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0004871 [signal transducer activity]
GO:0005834 [heterotrimeric G-protein complex]
GO:0005886 [plasma membrane]
GO:0006112 [energy reserve metabolic process]
GO:0007186 [G-protein coupled receptor signaling pathway]
GO:0007191 [adenylate cyclase-activating dopamine receptor signaling pathway]
GO:0007268 [synaptic transmission]
GO:0007596 [blood coagulation]
GO:0016020 [membrane]
GO:0030168 [platelet activation]
GO:0031681 [G-protein beta-subunit binding]
GO:0044281 [small molecule metabolic process]
GO:0070062 [extracellular exosome]
GO:0071377 [cellular response to glucagon stimulus]
GO:0071380 [cellular response to prostaglandin E stimulus]
GO:0071870 [cellular response to catecholamine stimulus]
Show all
 71 aa
7.9 kDa 		No 0
GNG2-002
ENSP00000334448
ENST00000335281
P59768 [Direct mapping]
Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2
Show all
Predicted intracellular proteins
RAS pathway related proteins
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0004871 [signal transducer activity]
GO:0005834 [heterotrimeric G-protein complex]
GO:0005886 [plasma membrane]
GO:0006112 [energy reserve metabolic process]
GO:0007186 [G-protein coupled receptor signaling pathway]
GO:0007191 [adenylate cyclase-activating dopamine receptor signaling pathway]
GO:0007268 [synaptic transmission]
GO:0007596 [blood coagulation]
GO:0008283 [cell proliferation]
GO:0016020 [membrane]
GO:0030168 [platelet activation]
GO:0031681 [G-protein beta-subunit binding]
GO:0044281 [small molecule metabolic process]
GO:0070062 [extracellular exosome]
GO:0071377 [cellular response to glucagon stimulus]
GO:0071380 [cellular response to prostaglandin E stimulus]
GO:0071870 [cellular response to catecholamine stimulus]
Show all
 71 aa
7.9 kDa 		No 0
GNG2-005
ENSP00000451231
ENST00000556766
P59768 [Direct mapping]
Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2
Show all
Predicted intracellular proteins
RAS pathway related proteins
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0004871 [signal transducer activity]
GO:0005834 [heterotrimeric G-protein complex]
GO:0005886 [plasma membrane]
GO:0006112 [energy reserve metabolic process]
GO:0007186 [G-protein coupled receptor signaling pathway]
GO:0007191 [adenylate cyclase-activating dopamine receptor signaling pathway]
GO:0007268 [synaptic transmission]
GO:0007596 [blood coagulation]
GO:0016020 [membrane]
GO:0030168 [platelet activation]
GO:0031681 [G-protein beta-subunit binding]
GO:0044281 [small molecule metabolic process]
GO:0070062 [extracellular exosome]
GO:0071377 [cellular response to glucagon stimulus]
GO:0071380 [cellular response to prostaglandin E stimulus]
GO:0071870 [cellular response to catecholamine stimulus]
Show all
 71 aa
7.9 kDa 		No 0
GNG2-006
ENSP00000450586
ENST00000553560
G3V2C9 [Direct mapping]
Guanine nucleotide-binding protein subunit gamma
Show all
Predicted intracellular proteins
RAS pathway related proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0004871 [signal transducer activity]
GO:0005834 [heterotrimeric G-protein complex]
GO:0007186 [G-protein coupled receptor signaling pathway]
Show all
 52 aa
5.9 kDa 		No 0
GNG2-009
ENSP00000452014
ENST00000554736
P59768 [Direct mapping]
Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2
Show all
Predicted intracellular proteins
RAS pathway related proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0004871 [signal transducer activity]
GO:0005834 [heterotrimeric G-protein complex]
GO:0005886 [plasma membrane]
GO:0006112 [energy reserve metabolic process]
GO:0007186 [G-protein coupled receptor signaling pathway]
GO:0007191 [adenylate cyclase-activating dopamine receptor signaling pathway]
GO:0007268 [synaptic transmission]
GO:0007596 [blood coagulation]
GO:0016020 [membrane]
GO:0030168 [platelet activation]
GO:0031681 [G-protein beta-subunit binding]
GO:0044281 [small molecule metabolic process]
GO:0070062 [extracellular exosome]
GO:0071377 [cellular response to glucagon stimulus]
GO:0071380 [cellular response to prostaglandin E stimulus]
GO:0071870 [cellular response to catecholamine stimulus]
Show all
 71 aa
7.9 kDa 		No 0
GNG2-010
ENSP00000451102
ENST00000555472
P59768 [Direct mapping]
Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2
Show all
Predicted intracellular proteins
RAS pathway related proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0004871 [signal transducer activity]
GO:0005834 [heterotrimeric G-protein complex]
GO:0005886 [plasma membrane]
GO:0006112 [energy reserve metabolic process]
GO:0007186 [G-protein coupled receptor signaling pathway]
GO:0007191 [adenylate cyclase-activating dopamine receptor signaling pathway]
GO:0007268 [synaptic transmission]
GO:0007596 [blood coagulation]
GO:0016020 [membrane]
GO:0030168 [platelet activation]
GO:0031681 [G-protein beta-subunit binding]
GO:0044281 [small molecule metabolic process]
GO:0070062 [extracellular exosome]
GO:0071377 [cellular response to glucagon stimulus]
GO:0071380 [cellular response to prostaglandin E stimulus]
GO:0071870 [cellular response to catecholamine stimulus]
Show all
 71 aa
7.9 kDa 		No 0
GNG2-012
ENSP00000451536
ENST00000554875
G3V415 [Direct mapping]
Guanine nucleotide-binding protein subunit gamma
Show all
Predicted intracellular proteins
RAS pathway related proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0004871 [signal transducer activity]
GO:0005834 [heterotrimeric G-protein complex]
GO:0007186 [G-protein coupled receptor signaling pathway]
Show all
 61 aa
6.9 kDa 		No 0
GNG2-014
ENSP00000451279
ENST00000553432
G3V3J9 [Direct mapping]
Guanine nucleotide-binding protein subunit gamma
Show all
Predicted intracellular proteins
RAS pathway related proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0004871 [signal transducer activity]
GO:0005834 [heterotrimeric G-protein complex]
GO:0007186 [G-protein coupled receptor signaling pathway]
Show all
 102 aa
11.2 kDa 		No 0
GNG2-016
ENSP00000450758
ENST00000557376
G3V2N0 [Direct mapping]
Guanine nucleotide-binding protein subunit gamma
Show all
Predicted intracellular proteins
RAS pathway related proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0004871 [signal transducer activity]
GO:0005834 [heterotrimeric G-protein complex]
GO:0007186 [G-protein coupled receptor signaling pathway]
Show all
 110 aa
12.4 kDa 		No 0
GNG2-201
ENSP00000484021
ENST00000615906
P59768 [Direct mapping]
Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2
Show all
Predicted intracellular proteins
RAS pathway related proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0004871 [signal transducer activity]
GO:0005834 [heterotrimeric G-protein complex]
GO:0005886 [plasma membrane]
GO:0006112 [energy reserve metabolic process]
GO:0007186 [G-protein coupled receptor signaling pathway]
GO:0007191 [adenylate cyclase-activating dopamine receptor signaling pathway]
GO:0007268 [synaptic transmission]
GO:0007596 [blood coagulation]
GO:0016020 [membrane]
GO:0030168 [platelet activation]
GO:0031681 [G-protein beta-subunit binding]
GO:0044281 [small molecule metabolic process]
GO:0070062 [extracellular exosome]
GO:0071377 [cellular response to glucagon stimulus]
GO:0071380 [cellular response to prostaglandin E stimulus]
GO:0071870 [cellular response to catecholamine stimulus]
Show all
 71 aa
7.9 kDa 		No 0

Contact

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.