Expression of BTN3A2 in cancer - Summary - The Human Protein Atlas

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BTN3A2

TISSUE

CELL

PATHOLOGY

PATHOLOGY ATLAS

GENE/PROTEIN

Antibody validation

Dictionary


Level of antibody staining/expression
	High Medium Low Not detected

GENERAL INFORMATION
Gene name	BTN3A2
Gene description	Butyrophilin, subfamily 3, member A2
Protein class	Predicted intracellular proteins Predicted membrane proteins Predicted secreted proteins
Predicted localization	Intracellular,Membrane,Secreted
Number of transcripts	10
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HUMAN PROTEIN ATLAS INFORMATION

RNA category

TCGA (cancer tissue):	Expressed in all
HPA (cell line):	Mixed
HPA (normal tissue):	Expressed in all

Protein evidence

Evidence at protein level

Protein expression
normal tissue

Cytoplasmic expression in most tissues.

ANTIBODY IHC RELIABILITY
Data reliability description	Antibody staining mainly consistent with RNA expression data. Pending external verification.
Reliability score	Uncertain based on 1 antibody. CAB019392
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PROGNOSTIC SUMMARY
Prognostic marker in renal cancer (unfavourable).
Renal cancer p<0.001 Show all

RNA EXPRESSION OVERVIEW
TCGA dataset RNA cancer category: Expressed in all

PROTEIN EXPRESSION

Colorectal cancer

Prostate cancer

STAINING SUMMARY

CAB019392

GENE INFORMATION
Gene name	BTN3A2 (HGNC Symbol)
Synonyms	BTN3.2
Description	Butyrophilin, subfamily 3, member A2 (HGNC Symbol)
Entrez gene summary	This gene encodes a member of the immunoglobulin superfamily, which resides in the juxta-telomeric region of the major histocompatability class 1 locus and is clustered with the other family members on chromosome 6. The encoded protein may be involved in the adaptive immune response. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jun 2013]
Chromosome	6
Cytoband	p22.2
Chromosome location (bp)	26365159 - 26378320
Protein evidence	Evidence at protein level (all genes)
Ensembl	ENSG00000186470 (version 83.38)
Entrez gene	11118
UniProt	P78410 (UniProt - Evidence at protein level)
neXtProt	NX_P78410
Antibodypedia	BTN3A2 antibodies

PROTEIN BROWSER

BTN3A2-001	BTN3A2-002	BTN3A2-003	BTN3A2-004	BTN3A2-005	BTN3A2-006	BTN3A2-008	BTN3A2-016	BTN3A2-201	BTN3A2-202

PROTEIN INFORMATION
Splice variant	UniProt	Protein class	Gene ontology	Length & mass	Signal peptide (predicted)	Transmembrane regions (predicted)
BTN3A2-001 ENSP00000348751 ENST00000356386	P78410 [Direct mapping] Butyrophilin subfamily 3 member A2 Show all	Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based 1TM proteins predicted by MDM Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0002456 [T cell mediated immunity] GO:0005515 [protein binding] GO:0005886 [plasma membrane] GO:0016020 [membrane] GO:0016021 [integral component of membrane] GO:0072643 [interferon-gamma secretion] Show all	334 aa 36.4 kDa	Yes	1
BTN3A2-002 ENSP00000366937 ENST00000377708	P78410 [Direct mapping] Butyrophilin subfamily 3 member A2 Show all	Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based 1TM proteins predicted by MDM Protein evidence (Ezkurdia et al 2014) Show all	GO:0002456 [T cell mediated immunity] GO:0005515 [protein binding] GO:0005886 [plasma membrane] GO:0016020 [membrane] GO:0016021 [integral component of membrane] GO:0072643 [interferon-gamma secretion] Show all	334 aa 36.4 kDa	Yes	1
BTN3A2-003 ENSP00000380152 ENST00000396948	P78410 [Direct mapping] Butyrophilin subfamily 3 member A2 Show all	Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based 1TM proteins predicted by MDM Protein evidence (Ezkurdia et al 2014) Show all	GO:0002456 [T cell mediated immunity] GO:0005515 [protein binding] GO:0005886 [plasma membrane] GO:0016020 [membrane] GO:0016021 [integral component of membrane] GO:0072643 [interferon-gamma secretion] Show all	334 aa 36.4 kDa	Yes	1
BTN3A2-004 ENSP00000432138 ENST00000527422	P78410 [Direct mapping] Butyrophilin subfamily 3 member A2 Show all	Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based 1TM proteins predicted by MDM Protein evidence (Ezkurdia et al 2014) Show all	GO:0002456 [T cell mediated immunity] GO:0005515 [protein binding] GO:0005886 [plasma membrane] GO:0016020 [membrane] GO:0016021 [integral component of membrane] GO:0072643 [interferon-gamma secretion] Show all	334 aa 36.4 kDa	Yes	1
BTN3A2-005 ENSP00000435952 ENST00000532865	E9PRR1 [Direct mapping] Butyrophilin subfamily 3 member A2 Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0005515 [protein binding] Show all	196 aa 21.1 kDa	No	0
BTN3A2-006 ENSP00000433749 ENST00000527417	E9PJE9 [Direct mapping] Butyrophilin subfamily 3 member A2 Show all	MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins THUMBUP predicted membrane proteins Predicted secreted proteins Secreted proteins predicted by MDSEC SignalP predicted secreted proteins Phobius predicted secreted proteins SPOCTOPUS predicted secreted proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0005515 [protein binding] Show all	160 aa 17.5 kDa	Yes	0
BTN3A2-008 ENSP00000434102 ENST00000530653	E9PRX1 [Direct mapping] Butyrophilin subfamily 3 member A2 Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0005515 [protein binding] Show all	115 aa 12.7 kDa	No	0
BTN3A2-016 ENSP00000474533 ENST00000527639	S4R3N0 [Direct mapping] Butyrophilin subfamily 3 member A2 Show all	Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based 1TM proteins predicted by MDM Protein evidence (Ezkurdia et al 2014) Show all	GO:0016021 [integral component of membrane] Show all	115 aa 12.9 kDa	No	1
BTN3A2-201 ENSP00000380140 ENST00000396934	P78410 [Direct mapping] Butyrophilin subfamily 3 member A2 Show all	Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based 1TM proteins predicted by MDM Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0002456 [T cell mediated immunity] GO:0005515 [protein binding] GO:0005886 [plasma membrane] GO:0016020 [membrane] GO:0016021 [integral component of membrane] GO:0072643 [interferon-gamma secretion] Show all	311 aa 33.9 kDa	No	1
BTN3A2-202 ENSP00000442687 ENST00000508906	P78410 [Direct mapping] Butyrophilin subfamily 3 member A2 Show all	Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based 1TM proteins predicted by MDM Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0002456 [T cell mediated immunity] GO:0005515 [protein binding] GO:0005886 [plasma membrane] GO:0016020 [membrane] GO:0016021 [integral component of membrane] GO:0072643 [interferon-gamma secretion] Show all	292 aa 32 kDa	No	1

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The Human Protein Atlas

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