Fields »
ABOUT
HELP
BLOG
PCLO

Please wait until image is loaded before changing channels

GENERAL INFORMATION

Gene name

 PCLO

Gene description

 Piccolo presynaptic cytomatrix protein

Protein class

 Disease related genes
Plasma proteins
Predicted intracellular proteins
Predicted membrane proteins

Predicted localization

 Intracellular,Membrane

Number of transcripts

 4
SHOW MORE

HUMAN PROTEIN ATLAS INFORMATION

Summary

 Localized to the plasma membrane & nuclear speckles.

RNA cell category

 Group enriched (U-2 OS, REH)

Protein evidence

 Evidence at protein level

Main location

 Localized to the Nuclear speckles (approved), Plasma membrane (approved)

DATA RELIABILITY

Reliability score

 Approved based on 1 antibody.
HPA029579
SHOW MORE

ASSAYS
RNA expression
Human cells

RNA EXPRESSION OVERVIEW
RNA cell line category: Group enriched (U-2 OS, REH)
Organ
Origin
Category
Expression
Alphabetical
Cell lines sorted after organ of phenotypic resemblance.

HUMAN CELLS

Summary

 Localized to the plasma membrane & nuclear speckles.

Main location

 Nuclear speckles (approved), Plasma membrane (approved)

 

 

 
Toggle channels
Low
High
G1
S
G2
M
N/A

Thumbnail

Antibody

Cell line

Location

Single-cell variation

Cell cycle dependent variation
HPA029579 A-431 Nuclear speckles
Plasma membrane
HPA029579 U-2 OS Nuclear speckles
Plasma membrane
HPA029579 U-251 MG Nuclear speckles
Plasma membrane

GENE INFORMATION

Gene name

 PCLO (HGNC Symbol)

Synonyms

 ACZ, DKFZp779G1236, KIAA0559

Description

 Piccolo presynaptic cytomatrix protein (HGNC Symbol)

Entrez gene summary

 The protein encoded by this gene is part of the presynaptic cytoskeletal matrix, which is involved in establishing active synaptic zones and in synaptic vesicle trafficking. Variations in this gene have been associated with bipolar disorder and major depressive disorder. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Nov 2011]

Chromosome

 7

Cytoband

 q21.11

Chromosome location (bp)

 82754013 - 83162930

Protein evidence

 Evidence at protein level (all genes)

Ensembl

 ENSG00000186472 (version 83.38)

Entrez gene

 27445

UniProt

 Q9Y6V0 (UniProt - Evidence at protein level)

neXtProt

 NX_Q9Y6V0

Antibodypedia

 PCLO antibodies

PROTEIN BROWSER
PCLO-001
PCLO-003
PCLO-011
PCLO-201

PROTEIN INFORMATION

Splice variant

UniProt

Protein class

Gene ontology

Length & mass

Signal peptide
(predicted)

Transmembrane regions
(predicted)
PCLO-001
ENSP00000334319
ENST00000333891
Q9Y6V0 [Direct mapping]
Protein piccolo
Show all
Predicted intracellular proteins
Plasma proteins
Disease related genes
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0005509 [calcium ion binding]
GO:0005515 [protein binding]
GO:0005522 [profilin binding]
GO:0005544 [calcium-dependent phospholipid binding]
GO:0005622 [intracellular]
GO:0005856 [cytoskeleton]
GO:0007010 [cytoskeleton organization]
GO:0007416 [synapse assembly]
GO:0014069 [postsynaptic density]
GO:0016020 [membrane]
GO:0016079 [synaptic vesicle exocytosis]
GO:0017157 [regulation of exocytosis]
GO:0019933 [cAMP-mediated signaling]
GO:0030054 [cell junction]
GO:0030073 [insulin secretion]
GO:0045202 [synapse]
GO:0046872 [metal ion binding]
GO:0048788 [cytoskeleton of presynaptic active zone]
GO:0070062 [extracellular exosome]
Show all
 5142 aa
560.7 kDa 		No 0
PCLO-003
ENSP00000393760
ENST00000437081
E9PE96 [Direct mapping]
Protein piccolo
Show all
Predicted membrane proteins
   Prediction method-based
   Membrane proteins predicted by MDM
   MEMSAT3 predicted membrane proteins
   MEMSAT-SVM predicted membrane proteins
   Phobius predicted membrane proteins
   SCAMPI predicted membrane proteins
   SPOCTOPUS predicted membrane proteins
   THUMBUP predicted membrane proteins
   TMHMM predicted membrane proteins
   # TM segments-based
   1TM proteins predicted by MDM
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0007416 [synapse assembly]
GO:0016021 [integral component of membrane]
GO:0048786 [presynaptic active zone]
Show all
 1217 aa
136.4 kDa 		No 1
PCLO-011
ENSP00000388393
ENST00000423517
Q9Y6V0 [Direct mapping]
Protein piccolo
Show all
Predicted intracellular proteins
Plasma proteins
Disease related genes
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0005509 [calcium ion binding]
GO:0005515 [protein binding]
GO:0005522 [profilin binding]
GO:0005544 [calcium-dependent phospholipid binding]
GO:0005856 [cytoskeleton]
GO:0007010 [cytoskeleton organization]
GO:0007416 [synapse assembly]
GO:0016020 [membrane]
GO:0016079 [synaptic vesicle exocytosis]
GO:0030054 [cell junction]
GO:0045202 [synapse]
GO:0046872 [metal ion binding]
GO:0048788 [cytoskeleton of presynaptic active zone]
GO:0070062 [extracellular exosome]
Show all
 4935 aa
537.9 kDa 		No 0
PCLO-201
ENSP00000482390
ENST00000618073
Q9Y6V0 [Direct mapping]
Protein piccolo
Show all
Predicted intracellular proteins
Plasma proteins
Disease related genes
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0005509 [calcium ion binding]
GO:0005515 [protein binding]
GO:0005522 [profilin binding]
GO:0005544 [calcium-dependent phospholipid binding]
GO:0005856 [cytoskeleton]
GO:0007010 [cytoskeleton organization]
GO:0007416 [synapse assembly]
GO:0016020 [membrane]
GO:0016079 [synaptic vesicle exocytosis]
GO:0030054 [cell junction]
GO:0045202 [synapse]
GO:0048788 [cytoskeleton of presynaptic active zone]
GO:0070062 [extracellular exosome]
Show all
 356 aa
39 kDa 		No 0

Contact

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.