Tissue expression of INSIG1 - Summary - The Human Protein Atlas

GENERAL INFORMATION
Gene name	INSIG1
Gene description	Insulin induced gene 1
Protein class	Plasma proteins Predicted membrane proteins
Predicted localization	Membrane
Number of transcripts	5
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HUMAN PROTEIN ATLAS INFORMATION

RNA tissue category

HPA:	Expressed in all
GTEx:	Expressed in all
FANTOM5:	Expressed in all

Protein evidence

Evidence at protein level

DATA RELIABILITY
Reliability score	Pending normal tissue annotation.

RNA AND PROTEIN EXPRESSION SUMMARY

RNA expression (TPM)

Protein expression (score)

Brain

N/A

Cerebral cortex

N/A

Hippocampus

N/A

Caudate

N/A

Cerebellum

N/A

Endocrine tissues

N/A

Thyroid gland

N/A

Parathyroid gland

N/A

Adrenal gland

N/A

Bone marrow & immune system

N/A

Appendix

N/A

Bone marrow

N/A

Lymph node

N/A

Tonsil

N/A

Spleen

N/A

Muscle tissues

N/A

Heart muscle

N/A

Skeletal muscle

N/A

Smooth muscle

N/A

Lung

N/A

Nasopharynx

N/A

Bronchus

N/A

Lung

N/A

Liver & gallbladder

N/A

Liver

N/A

Gallbladder

N/A

Pancreas

N/A

Pancreas

N/A

Gastrointestinal tract

N/A

Oral mucosa

N/A

Salivary gland

N/A

Esophagus

N/A

Stomach

N/A

Duodenum

N/A

Small intestine

N/A

Colon

N/A

Rectum

N/A

Kidney & urinary bladder

N/A

Kidney

N/A

Urinary bladder

N/A

Male tissues

N/A

Testis

N/A

Epididymis

N/A

Prostate

N/A

Seminal vesicle

N/A

Female tissues

N/A

Breast

N/A

Vagina

N/A

Cervix, uterine

N/A

Endometrium

N/A

Fallopian tube

N/A

Ovary

N/A

Placenta

N/A

Adipose & soft tissue

N/A

Adipose tissue

N/A

Soft tissue

N/A

Skin

N/A

Skin

N/A

PROTEIN EXPRESSION OVERVIEW
Pending normal tissue annotation.

RNA EXPRESSION OVERVIEW
HPA dataset Organ Expression Alphabetical RNA tissue category: Expressed in all
GTEx dataset Organ Expression Alphabetical RNA tissue category: Expressed in all
FANTOM5 dataset Organ Expression Alphabetical RNA tissue category: Expressed in all

GENE INFORMATION
Gene name	INSIG1 (HGNC Symbol)
Synonyms	CL-6, MGC1405
Description	Insulin induced gene 1 (HGNC Symbol)
Entrez gene summary	Oxysterols regulate cholesterol homeostasis through the liver X receptor (LXR)- and sterol regulatory element-binding protein (SREBP)-mediated signaling pathways. This gene is an insulin-induced gene. It encodes an endoplasmic reticulum (ER) membrane protein that plays a critical role in regulating cholesterol concentrations in cells. This protein binds to the sterol-sensing domains of SREBP cleavage-activating protein (SCAP) and HMG CoA reductase, and is essential for the sterol-mediated trafficking of the two proteins. Alternatively spliced transcript variants encoding distinct isoforms have been observed. [provided by RefSeq, Jun 2009]
Chromosome	7
Cytoband	q36.3
Chromosome location (bp)	155297776 - 155310235
Protein evidence	Evidence at protein level (all genes)
Ensembl	ENSG00000186480 (version 83.38)
Entrez gene	3638
UniProt	O15503 (UniProt - Evidence at protein level)
neXtProt	NX_O15503
Antibodypedia	INSIG1 antibodies

PROTEIN BROWSER

INSIG1-001	INSIG1-002	INSIG1-003	INSIG1-005	INSIG1-201

PROTEIN INFORMATION
Splice variant	UniProt	Protein class	Gene ontology	Length & mass	Signal peptide (predicted)	Transmembrane regions (predicted)
INSIG1-001 ENSP00000344741 ENST00000340368	O15503 [Direct mapping] Insulin-induced gene 1 protein A0A024RD68 [Target identity:100%; Query identity:100%] Insulin-induced gene protein Show all	Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based 6TM proteins predicted by MDM Plasma proteins Show all	GO:0005515 [protein binding] GO:0005783 [endoplasmic reticulum] GO:0005789 [endoplasmic reticulum membrane] GO:0006641 [triglyceride metabolic process] GO:0006695 [cholesterol biosynthetic process] GO:0006991 [response to sterol depletion] GO:0008152 [metabolic process] GO:0008203 [cholesterol metabolic process] GO:0008283 [cell proliferation] GO:0010894 [negative regulation of steroid biosynthetic process] GO:0016126 [sterol biosynthetic process] GO:0032933 [SREBP signaling pathway] GO:0032937 [SREBP-SCAP-Insig complex] GO:0042472 [inner ear morphogenesis] GO:0042474 [middle ear morphogenesis] GO:0044281 [small molecule metabolic process] GO:0045599 [negative regulation of fat cell differentiation] GO:0045717 [negative regulation of fatty acid biosynthetic process] GO:0060021 [palate development] GO:0060363 [cranial suture morphogenesis] GO:1901303 [negative regulation of cargo loading into COPII-coated vesicle] Show all	277 aa 30 kDa	No	6
INSIG1-002 ENSP00000414691 ENST00000425172	C9JSG8 [Direct mapping] Insulin-induced gene 1 protein Show all	Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based 1TM proteins predicted by MDM Show all	GO:0008203 [cholesterol metabolic process] GO:0016021 [integral component of membrane] Show all	123 aa 13.2 kDa	No	1
INSIG1-003 ENSP00000344035 ENST00000342407	O15503 [Direct mapping] Insulin-induced gene 1 protein Show all	Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based 1TM proteins predicted by MDM Plasma proteins Show all	GO:0005515 [protein binding] GO:0005783 [endoplasmic reticulum] GO:0005789 [endoplasmic reticulum membrane] GO:0008152 [metabolic process] GO:0008283 [cell proliferation] GO:0032933 [SREBP signaling pathway] GO:0032937 [SREBP-SCAP-Insig complex] GO:0044281 [small molecule metabolic process] GO:1901303 [negative regulation of cargo loading into COPII-coated vesicle] Show all	164 aa 17.5 kDa	No	1
INSIG1-005 ENSP00000420198 ENST00000476756	H7C5L3 [Direct mapping] Insulin-induced gene protein Show all	Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based 4TM proteins predicted by MDM Show all	GO:0008203 [cholesterol metabolic process] GO:0016021 [integral component of membrane] Show all	239 aa 26.7 kDa	Yes	4
INSIG1-201 ENSP00000340010 ENST00000344756	F5H6P3 [Direct mapping] Insulin-induced gene protein Show all	Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based 3TM proteins predicted by MDM Show all	GO:0008203 [cholesterol metabolic process] GO:0016021 [integral component of membrane] Show all	178 aa 20.4 kDa	No	3