Cell atlas - SEPT10 - The Human Protein Atlas

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SEPT10

TISSUE

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CELL

PATHOLOGY

CELL ATLAS RNA EXPRESSION HUMAN CELLS

GENE/PROTEIN

Antibody validation

Dictionary
	Actin filaments

Human cell
	Actin Filaments

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GENERAL INFORMATION
Gene name	SEPT10
Gene description	Septin 10
Protein class	Predicted intracellular proteins
Predicted localization	Intracellular
Number of transcripts	10
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HUMAN PROTEIN ATLAS INFORMATION
Summary	Mainly localized to the actin filaments.
RNA cell category	Mixed
Protein evidence	Evidence at protein level
Main location	Localized to the Actin filaments (validated)

DATA RELIABILITY
Reliability score	Validated based on 2 antibodies. HPA047860 , HPA060310
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ASSAYS

RNA EXPRESSION OVERVIEW
RNA cell line category: Mixed Organ Origin Category Expression Alphabetical Cell lines sorted after organ of phenotypic resemblance. Cell lines sorted after biological source for establishment. Cell lines sorted after the cell line category according to Cellosaurus. Cell lines sorted on descending RNA expression. Cell lines sorted alphabetically.

HUMAN CELLS

Summary

Mainly localized to the actin filaments.

Main location

Actin filaments (validated)


	Toggle channels	Low High G1 S G2 M N/A

Thumbnail	Antibody	Cell line	Location	Single-cell variation	Cell cycle dependent variation
	HPA047860	A-431	Actin filaments
	HPA047860	U-2 OS	Actin filaments
	HPA060310	A-431	Nucleus
	HPA060310	A-431	Actin filaments
	HPA060310	U-2 OS	Nucleus
	HPA060310	U-2 OS	Actin filaments

GENE INFORMATION
Gene name	SEPT10 (HGNC Symbol)
Synonyms	FLJ11619
Description	Septin 10 (HGNC Symbol)
Entrez gene summary	This gene encodes a member of the septin family of cytoskeletal proteins with GTPase activity. This protein localizes to the cytoplasm and nucleus and displays GTP-binding and GTPase activity. A pseudogene for this gene is located on chromosome 8. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Apr 2012]
Chromosome	2
Cytoband	q13
Chromosome location (bp)	109542982 - 109614206
Protein evidence	Evidence at protein level (all genes)
Ensembl	ENSG00000186522 (version 83.38)
Entrez gene	151011
UniProt	Q9P0V9 (UniProt - Evidence at protein level)
neXtProt	NX_Q9P0V9
Antibodypedia	SEPT10 antibodies

PROTEIN BROWSER

SEPT10-001	SEPT10-002	SEPT10-003	SEPT10-004	SEPT10-006	SEPT10-007	SEPT10-008	SEPT10-010	SEPT10-012	SEPT10-013

PROTEIN INFORMATION
Splice variant	UniProt	Protein class	Gene ontology	Length & mass	Signal peptide (predicted)	Transmembrane regions (predicted)
SEPT10-001 ENSP00000380824 ENST00000397712	Q9P0V9 [Direct mapping] Septin-10 Show all	Predicted intracellular proteins Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0005515 [protein binding] GO:0005525 [GTP binding] GO:0005737 [cytoplasm] GO:0005856 [cytoskeleton] GO:0007049 [cell cycle] GO:0051301 [cell division] Show all	454 aa 52.6 kDa	No	0
SEPT10-002 ENSP00000349116 ENST00000356688	B5ME97 [Direct mapping] Septin 10, isoform CRA_c; Septin-10 Show all	SPOCTOPUS predicted membrane proteins Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0005515 [protein binding] GO:0005525 [GTP binding] Show all	544 aa 62.9 kDa	No	0
SEPT10-003 ENSP00000407790 ENST00000437928	E7EX04 [Direct mapping] Septin-10 Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0005525 [GTP binding] Show all	473 aa 54.6 kDa	No	0
SEPT10-004 ENSP00000396728 ENST00000415095	E7EW69 [Direct mapping] Septin-10 Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0005525 [GTP binding] Show all	450 aa 52.1 kDa	No	0
SEPT10-006 ENSP00000380826 ENST00000397714	Q9P0V9 [Direct mapping] Septin-10 Show all	Predicted intracellular proteins Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0005515 [protein binding] GO:0005525 [GTP binding] GO:0005737 [cytoplasm] GO:0005856 [cytoskeleton] GO:0007049 [cell cycle] GO:0051301 [cell division] Show all	431 aa 50.1 kDa	No	0
SEPT10-007 ENSP00000408392 ENST00000442746	C9JNR7 [Direct mapping] Septin-10 Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0005525 [GTP binding] Show all	61 aa 6.9 kDa	No	0
SEPT10-008 ENSP00000396051 ENST00000411469	C9JEW2 [Direct mapping] Septin-10 Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0005525 [GTP binding] Show all	58 aa 6.4 kDa	No	0
SEPT10-010 ENSP00000416597 ENST00000423520	C9JEQ7 [Direct mapping] Septin-10 Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0005525 [GTP binding] Show all	97 aa 10.5 kDa	No	0
SEPT10-012 ENSP00000445707 ENST00000493445	F5H1F2 [Direct mapping] Septin-10 Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0005525 [GTP binding] Show all	98 aa 10.9 kDa	No	0
SEPT10-013 ENSP00000441218 ENST00000461295	F5GYV2 [Direct mapping] Septin-10 Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0005525 [GTP binding] Show all	26 aa 2.9 kDa	No	0

Contact

contact@proteinatlas.org

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.