Fields »
ABOUT
HELP
BLOG
FOXE3

Please wait until image is loaded before changing channels

GENERAL INFORMATION

Gene name

 FOXE3

Gene description

 Forkhead box E3

Protein class

 Disease related genes
Predicted intracellular proteins
Transcription factors

Predicted localization

 Intracellular

Number of transcripts

 1
SHOW MORE

HUMAN PROTEIN ATLAS INFORMATION

Summary

RNA cell category

 Not detected

Protein evidence

 Evidence at protein level

Main location

 Not available

DATA RELIABILITY

Reliability score

 Pending cell analysis.

ASSAYS
RNA expression

RNA EXPRESSION OVERVIEW
RNA cell line category: Not detected
Organ
Origin
Category
Expression
Alphabetical
Cell lines sorted after organ of phenotypic resemblance.

GENE INFORMATION

Gene name

 FOXE3 (HGNC Symbol)

Synonyms

 FKHL12, FREAC8

Description

 Forkhead box E3 (HGNC Symbol)

Entrez gene summary

 This intronless gene belongs to the forkhead family of transcription factors, which is characterized by a distinct forkhead domain. The protein encoded functions as a lens-specific transcription factor and plays an important role in vertebrate lens formation. Mutations in this gene are associated with anterior segment mesenchymal dysgenesis and congenital primary aphakia. [provided by RefSeq, Dec 2009]

Chromosome

 1

Cytoband

 p33

Chromosome location (bp)

 47416072 - 47418052

Protein evidence

 Evidence at protein level (all genes)

Ensembl

 ENSG00000186790 (version 83.38)

Entrez gene

 2301

UniProt

 Q13461 (UniProt - Evidence at protein level)

neXtProt

 NX_Q13461

Antibodypedia

 FOXE3 antibodies

PROTEIN BROWSER
FOXE3-001

PROTEIN INFORMATION

Splice variant

UniProt

Protein class

Gene ontology

Length & mass

Signal peptide
(predicted)

Transmembrane regions
(predicted)
FOXE3-001
ENSP00000334472
ENST00000335071
Q13461 [Direct mapping]
Forkhead box protein E3
A0A0A1EII5 [Target identity:100%; Query identity:100%]
Forkhead box protein E3
Show all
Predicted intracellular proteins
Transcription factors
   Helix-turn-helix domains
Disease related genes
Show all
GO:0000981 [RNA polymerase II transcription factor activity, sequence-specific DNA binding]
GO:0001654 [eye development]
GO:0002088 [lens development in camera-type eye]
GO:0002930 [trabecular meshwork development]
GO:0003677 [DNA binding]
GO:0003700 [transcription factor activity, sequence-specific DNA binding]
GO:0005634 [nucleus]
GO:0005667 [transcription factor complex]
GO:0006355 [regulation of transcription, DNA-templated]
GO:0006357 [regulation of transcription from RNA polymerase II promoter]
GO:0006366 [transcription from RNA polymerase II promoter]
GO:0009653 [anatomical structure morphogenesis]
GO:0030154 [cell differentiation]
GO:0043010 [camera-type eye development]
GO:0043066 [negative regulation of apoptotic process]
GO:0043565 [sequence-specific DNA binding]
GO:0048468 [cell development]
GO:0050679 [positive regulation of epithelial cell proliferation]
GO:0061072 [iris morphogenesis]
GO:0061073 [ciliary body morphogenesis]
GO:0061303 [cornea development in camera-type eye]
GO:0071157 [negative regulation of cell cycle arrest]
GO:1902747 [negative regulation of lens fiber cell differentiation]
GO:2001111 [positive regulation of lens epithelial cell proliferation]
Show all
 319 aa
33.2 kDa 		No 0

Contact

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.