Tissue expression of FOXE3 - Summary - The Human Protein Atlas

GENERAL INFORMATION
Gene name	FOXE3
Gene description	Forkhead box E3
Protein class	Disease related genes Predicted intracellular proteins Transcription factors
Predicted localization	Intracellular
Number of transcripts	1
	SHOW MORE

HUMAN PROTEIN ATLAS INFORMATION

RNA tissue category

HPA:	Not detected
GTEx:	Tissue enhanced (testis)
FANTOM5:	Not detected

Protein evidence

Evidence at protein level

DATA RELIABILITY
Reliability score	Pending normal tissue annotation.

RNA AND PROTEIN EXPRESSION SUMMARY

RNA expression (TPM)

Protein expression (score)

Brain

N/A

Cerebral cortex

N/A

Hippocampus

N/A

Caudate

N/A

Cerebellum

N/A

Endocrine tissues

N/A

Thyroid gland

N/A

Parathyroid gland

N/A

Adrenal gland

N/A

Bone marrow & immune system

N/A

Appendix

N/A

Bone marrow

N/A

Lymph node

N/A

Tonsil

N/A

Spleen

N/A

Muscle tissues

N/A

Heart muscle

N/A

Skeletal muscle

N/A

Smooth muscle

N/A

Lung

N/A

Nasopharynx

N/A

Bronchus

N/A

Lung

N/A

Liver & gallbladder

N/A

Liver

N/A

Gallbladder

N/A

Pancreas

N/A

Pancreas

N/A

Gastrointestinal tract

N/A

Oral mucosa

N/A

Salivary gland

N/A

Esophagus

N/A

Stomach

N/A

Duodenum

N/A

Small intestine

N/A

Colon

N/A

Rectum

N/A

Kidney & urinary bladder

N/A

Kidney

N/A

Urinary bladder

N/A

Male tissues

N/A

Testis

N/A

Epididymis

N/A

Prostate

N/A

Seminal vesicle

N/A

Female tissues

N/A

Breast

N/A

Vagina

N/A

Cervix, uterine

N/A

Endometrium

N/A

Fallopian tube

N/A

Ovary

N/A

Placenta

N/A

Adipose & soft tissue

N/A

Adipose tissue

N/A

Soft tissue

N/A

Skin

N/A

Skin

N/A

PROTEIN EXPRESSION OVERVIEW
Pending normal tissue annotation.

RNA EXPRESSION OVERVIEW
HPA dataset Organ Expression Alphabetical RNA tissue category: Not detected
GTEx dataset Organ Expression Alphabetical RNA tissue category: Tissue enhanced (testis)
FANTOM5 dataset Organ Expression Alphabetical RNA tissue category: Not detected

GENE INFORMATION
Gene name	FOXE3 (HGNC Symbol)
Synonyms	FKHL12, FREAC8
Description	Forkhead box E3 (HGNC Symbol)
Entrez gene summary	This intronless gene belongs to the forkhead family of transcription factors, which is characterized by a distinct forkhead domain. The protein encoded functions as a lens-specific transcription factor and plays an important role in vertebrate lens formation. Mutations in this gene are associated with anterior segment mesenchymal dysgenesis and congenital primary aphakia. [provided by RefSeq, Dec 2009]
Chromosome	1
Cytoband	p33
Chromosome location (bp)	47416072 - 47418052
Protein evidence	Evidence at protein level (all genes)
Ensembl	ENSG00000186790 (version 83.38)
Entrez gene	2301
UniProt	Q13461 (UniProt - Evidence at protein level)
neXtProt	NX_Q13461
Antibodypedia	FOXE3 antibodies

PROTEIN BROWSER

FOXE3-001

PROTEIN INFORMATION
Splice variant	UniProt	Protein class	Gene ontology	Length & mass	Signal peptide (predicted)	Transmembrane regions (predicted)
FOXE3-001 ENSP00000334472 ENST00000335071	Q13461 [Direct mapping] Forkhead box protein E3 A0A0A1EII5 [Target identity:100%; Query identity:100%] Forkhead box protein E3 Show all	Predicted intracellular proteins Transcription factors Helix-turn-helix domains Disease related genes Show all	GO:0000981 [RNA polymerase II transcription factor activity, sequence-specific DNA binding] GO:0001654 [eye development] GO:0002088 [lens development in camera-type eye] GO:0002930 [trabecular meshwork development] GO:0003677 [DNA binding] GO:0003700 [transcription factor activity, sequence-specific DNA binding] GO:0005634 [nucleus] GO:0005667 [transcription factor complex] GO:0006355 [regulation of transcription, DNA-templated] GO:0006357 [regulation of transcription from RNA polymerase II promoter] GO:0006366 [transcription from RNA polymerase II promoter] GO:0009653 [anatomical structure morphogenesis] GO:0030154 [cell differentiation] GO:0043010 [camera-type eye development] GO:0043066 [negative regulation of apoptotic process] GO:0043565 [sequence-specific DNA binding] GO:0048468 [cell development] GO:0050679 [positive regulation of epithelial cell proliferation] GO:0061072 [iris morphogenesis] GO:0061073 [ciliary body morphogenesis] GO:0061303 [cornea development in camera-type eye] GO:0071157 [negative regulation of cell cycle arrest] GO:1902747 [negative regulation of lens fiber cell differentiation] GO:2001111 [positive regulation of lens epithelial cell proliferation] Show all	319 aa 33.2 kDa	No	0