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TPCN1

GENERAL INFORMATION

Gene name

 TPCN1

Gene description

 Two pore segment channel 1

Protein class

 Predicted intracellular proteins
Predicted membrane proteins
Transporters
Voltage-gated ion channels

Predicted localization

 Intracellular,Membrane

Number of transcripts

 15
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HUMAN PROTEIN ATLAS INFORMATION

RNA category
TCGA (cancer tissue):Expressed in all
HPA (cell line):Expressed in all
HPA (normal tissue):Expressed in all

Protein evidence

 Evidence at protein level

Protein expression
normal tissue

 Cytoplasmic expression in several tissues.

ANTIBODY IHC RELIABILITY

Data reliability
description

 Antibody staining mainly consistent with RNA expression data.

Reliability score

 Approved based on 1 antibody.
HPA039757
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PROGNOSTIC SUMMARY
Gene product is not prognostic.
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RNA EXPRESSION OVERVIEW
TCGA dataset
RNA cancer category: Expressed in all

PROTEIN EXPRESSION
Colorectal cancer
Breast cancer
Prostate cancer
Lung cancer
Liver cancer

STAINING SUMMARY
HPA039757

GENE INFORMATION

Gene name

 TPCN1 (HGNC Symbol)

Synonyms

 FLJ20612, KIAA1169, TPC1

Description

 Two pore segment channel 1 (HGNC Symbol)

Entrez gene summary

 Voltage-gated Ca(2+) and Na+ channels have 4 homologous domains, each containing 6 transmembrane segments, S1 to S6. TPCN1 is similar to these channels, but it has only 2 domains containing S1 to S6 (Ishibashi et al., 2000 [PubMed 10753632]).[supplied by OMIM, Mar 2008]

Chromosome

 12

Cytoband

 q24.13

Chromosome location (bp)

 113221050 - 113298585

Protein evidence

 Evidence at protein level (all genes)

Ensembl

 ENSG00000186815 (version 83.38)

Entrez gene

 53373

UniProt

 Q9ULQ1 (UniProt - Evidence at protein level)

neXtProt

 NX_Q9ULQ1

Antibodypedia

 TPCN1 antibodies

PROTEIN BROWSER
«
TPCN1-001
TPCN1-002
TPCN1-003
TPCN1-011
TPCN1-013
TPCN1-014
TPCN1-015
TPCN1-016
TPCN1-017
TPCN1-018
TPCN1-019
TPCN1-020
TPCN1-021
TPCN1-022
TPCN1-201
»

PROTEIN INFORMATION

Splice variant

UniProt

Protein class

Gene ontology

Length & mass

Signal peptide
(predicted)

Transmembrane regions
(predicted)
TPCN1-001
ENSP00000335300
ENST00000335509
Q9ULQ1 [Direct mapping]
Two pore calcium channel protein 1
Show all
Transporters
   Transporter channels and pores
Voltage-gated ion channels
   CatSper and Two-Pore Channels
Predicted membrane proteins
   Prediction method-based
   Membrane proteins predicted by MDM
   MEMSAT3 predicted membrane proteins
   MEMSAT-SVM predicted membrane proteins
   Phobius predicted membrane proteins
   SCAMPI predicted membrane proteins
   SPOCTOPUS predicted membrane proteins
   THUMBUP predicted membrane proteins
   TMHMM predicted membrane proteins
   # TM segments-based
   >9TM proteins predicted by MDM
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0005216 [ion channel activity]
GO:0005245 [voltage-gated calcium channel activity]
GO:0005515 [protein binding]
GO:0005765 [lysosomal membrane]
GO:0005886 [plasma membrane]
GO:0006811 [ion transport]
GO:0006816 [calcium ion transport]
GO:0010008 [endosome membrane]
GO:0016020 [membrane]
GO:0016021 [integral component of membrane]
GO:0034220 [ion transmembrane transport]
GO:0034765 [regulation of ion transmembrane transport]
GO:0042802 [identical protein binding]
GO:0055085 [transmembrane transport]
GO:0070588 [calcium ion transmembrane transport]
GO:0072345 [NAADP-sensitive calcium-release channel activity]
GO:0086010 [membrane depolarization during action potential]
Show all
 816 aa
94.1 kDa 		No >9
TPCN1-002
ENSP00000448083
ENST00000550785
Q9ULQ1 [Direct mapping]
Two pore calcium channel protein 1
Show all
Transporters
   Transporter channels and pores
Voltage-gated ion channels
   CatSper and Two-Pore Channels
Predicted membrane proteins
   Prediction method-based
   Membrane proteins predicted by MDM
   MEMSAT3 predicted membrane proteins
   MEMSAT-SVM predicted membrane proteins
   Phobius predicted membrane proteins
   SCAMPI predicted membrane proteins
   SPOCTOPUS predicted membrane proteins
   THUMBUP predicted membrane proteins
   TMHMM predicted membrane proteins
   # TM segments-based
   >9TM proteins predicted by MDM
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0005216 [ion channel activity]
GO:0005245 [voltage-gated calcium channel activity]
GO:0005515 [protein binding]
GO:0005765 [lysosomal membrane]
GO:0005886 [plasma membrane]
GO:0006811 [ion transport]
GO:0006816 [calcium ion transport]
GO:0010008 [endosome membrane]
GO:0016020 [membrane]
GO:0016021 [integral component of membrane]
GO:0034220 [ion transmembrane transport]
GO:0034765 [regulation of ion transmembrane transport]
GO:0042802 [identical protein binding]
GO:0055085 [transmembrane transport]
GO:0070588 [calcium ion transmembrane transport]
GO:0072345 [NAADP-sensitive calcium-release channel activity]
GO:0086010 [membrane depolarization during action potential]
Show all
 888 aa
101.8 kDa 		No >9
TPCN1-003
ENSP00000376350
ENST00000392569
B7Z3R2 [Direct mapping]
Two pore calcium channel protein 1; cDNA FLJ54008, highly similar to Homo sapiens two pore segment channel 1 (TPCN1), mRNA
Show all
Predicted membrane proteins
   Prediction method-based
   Membrane proteins predicted by MDM
   MEMSAT3 predicted membrane proteins
   MEMSAT-SVM predicted membrane proteins
   Phobius predicted membrane proteins
   SCAMPI predicted membrane proteins
   SPOCTOPUS predicted membrane proteins
   THUMBUP predicted membrane proteins
   TMHMM predicted membrane proteins
   # TM segments-based
   >9TM proteins predicted by MDM
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0005216 [ion channel activity]
GO:0005245 [voltage-gated calcium channel activity]
GO:0005886 [plasma membrane]
GO:0006811 [ion transport]
GO:0006816 [calcium ion transport]
GO:0016020 [membrane]
GO:0016021 [integral component of membrane]
GO:0034220 [ion transmembrane transport]
GO:0034765 [regulation of ion transmembrane transport]
GO:0055085 [transmembrane transport]
GO:0070588 [calcium ion transmembrane transport]
GO:0086010 [membrane depolarization during action potential]
Show all
 748 aa
87.3 kDa 		No >9
TPCN1-011
ENSP00000449564
ENST00000546781
H0YIK4 [Direct mapping]
Two pore calcium channel protein 1
Show all
Predicted membrane proteins
   Prediction method-based
   Membrane proteins predicted by MDM
   MEMSAT3 predicted membrane proteins
   MEMSAT-SVM predicted membrane proteins
   Phobius predicted membrane proteins
   SCAMPI predicted membrane proteins
   SPOCTOPUS predicted membrane proteins
   THUMBUP predicted membrane proteins
   TMHMM predicted membrane proteins
   # TM segments-based
   2TM proteins predicted by MDM
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0005216 [ion channel activity]
GO:0005245 [voltage-gated calcium channel activity]
GO:0005886 [plasma membrane]
GO:0006811 [ion transport]
GO:0006816 [calcium ion transport]
GO:0016020 [membrane]
GO:0016021 [integral component of membrane]
GO:0034220 [ion transmembrane transport]
GO:0034765 [regulation of ion transmembrane transport]
GO:0055085 [transmembrane transport]
GO:0070588 [calcium ion transmembrane transport]
GO:0086010 [membrane depolarization during action potential]
Show all
 204 aa
23.8 kDa 		No 2
TPCN1-013
ENSP00000448561
ENST00000548465
F8VR74 [Direct mapping]
Two pore calcium channel protein 1
Show all
Predicted membrane proteins
   Prediction method-based
   Membrane proteins predicted by MDM
   MEMSAT3 predicted membrane proteins
   MEMSAT-SVM predicted membrane proteins
   Phobius predicted membrane proteins
   SCAMPI predicted membrane proteins
   SPOCTOPUS predicted membrane proteins
   THUMBUP predicted membrane proteins
   TMHMM predicted membrane proteins
   # TM segments-based
   3TM proteins predicted by MDM
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0005245 [voltage-gated calcium channel activity]
GO:0005886 [plasma membrane]
GO:0006816 [calcium ion transport]
GO:0016021 [integral component of membrane]
GO:0034220 [ion transmembrane transport]
GO:0070588 [calcium ion transmembrane transport]
GO:0086010 [membrane depolarization during action potential]
Show all
 145 aa
16.7 kDa 		No 3
TPCN1-014
ENSP00000448704
ENST00000549279
F8W0K7 [Direct mapping]
Two pore calcium channel protein 1
Show all
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0005245 [voltage-gated calcium channel activity]
GO:0005886 [plasma membrane]
GO:0006816 [calcium ion transport]
GO:0034220 [ion transmembrane transport]
GO:0070588 [calcium ion transmembrane transport]
GO:0086010 [membrane depolarization during action potential]
Show all
 100 aa
10.7 kDa 		No 0
TPCN1-015
ENSP00000449560
ENST00000547275
F8VVY9 [Direct mapping]
Two pore calcium channel protein 1
Show all
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0005245 [voltage-gated calcium channel activity]
GO:0005886 [plasma membrane]
GO:0006816 [calcium ion transport]
GO:0034220 [ion transmembrane transport]
GO:0070588 [calcium ion transmembrane transport]
GO:0086010 [membrane depolarization during action potential]
Show all
 147 aa
15.7 kDa 		No 0
TPCN1-016
ENSP00000447569
ENST00000552985
F8W0P9 [Direct mapping]
Two pore calcium channel protein 1
Show all
Predicted membrane proteins
   Prediction method-based
   Membrane proteins predicted by MDM
   MEMSAT3 predicted membrane proteins
   MEMSAT-SVM predicted membrane proteins
   Phobius predicted membrane proteins
   SCAMPI predicted membrane proteins
   SPOCTOPUS predicted membrane proteins
   THUMBUP predicted membrane proteins
   # TM segments-based
   1TM proteins predicted by MDM
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0005245 [voltage-gated calcium channel activity]
GO:0005886 [plasma membrane]
GO:0006816 [calcium ion transport]
GO:0034220 [ion transmembrane transport]
GO:0070588 [calcium ion transmembrane transport]
GO:0086010 [membrane depolarization during action potential]
Show all
 215 aa
22.9 kDa 		No 1
TPCN1-017
ENSP00000447806
ENST00000552642
F8VS97 [Direct mapping]
Two pore calcium channel protein 1
Show all
Predicted membrane proteins
   Prediction method-based
   Membrane proteins predicted by MDM
   MEMSAT3 predicted membrane proteins
   MEMSAT-SVM predicted membrane proteins
   Phobius predicted membrane proteins
   SCAMPI predicted membrane proteins
   SPOCTOPUS predicted membrane proteins
   THUMBUP predicted membrane proteins
   # TM segments-based
   1TM proteins predicted by MDM
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0005245 [voltage-gated calcium channel activity]
GO:0005886 [plasma membrane]
GO:0006816 [calcium ion transport]
GO:0034220 [ion transmembrane transport]
GO:0070588 [calcium ion transmembrane transport]
GO:0086010 [membrane depolarization during action potential]
Show all
 126 aa
13.7 kDa 		No 1
TPCN1-018
ENSP00000447073
ENST00000550873
F8W1G4 [Direct mapping]
Two pore calcium channel protein 1
Show all
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0005245 [voltage-gated calcium channel activity]
GO:0005886 [plasma membrane]
GO:0006816 [calcium ion transport]
GO:0034220 [ion transmembrane transport]
GO:0070588 [calcium ion transmembrane transport]
GO:0086010 [membrane depolarization during action potential]
Show all
 85 aa
8.8 kDa 		No 0
TPCN1-019
ENSP00000447263
ENST00000551096
F8VZZ6 [Direct mapping]
Two pore calcium channel protein 1
Show all
   SPOCTOPUS predicted secreted proteins
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0005245 [voltage-gated calcium channel activity]
GO:0005886 [plasma membrane]
GO:0006816 [calcium ion transport]
GO:0034220 [ion transmembrane transport]
GO:0070588 [calcium ion transmembrane transport]
GO:0086010 [membrane depolarization during action potential]
Show all
 124 aa
12.9 kDa 		No 0
TPCN1-020
ENSP00000447181
ENST00000551099
F8W0K7 [Direct mapping]
Two pore calcium channel protein 1
Show all
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0005245 [voltage-gated calcium channel activity]
GO:0005886 [plasma membrane]
GO:0006816 [calcium ion transport]
GO:0034220 [ion transmembrane transport]
GO:0070588 [calcium ion transmembrane transport]
GO:0086010 [membrane depolarization during action potential]
Show all
 100 aa
10.7 kDa 		No 0
TPCN1-021
ENSP00000449944
ENST00000552897
F8VV93 [Direct mapping]
Two pore calcium channel protein 1
Show all
Predicted membrane proteins
   Prediction method-based
   Membrane proteins predicted by MDM
   MEMSAT3 predicted membrane proteins
   MEMSAT-SVM predicted membrane proteins
   Phobius predicted membrane proteins
   SCAMPI predicted membrane proteins
   SPOCTOPUS predicted membrane proteins
   THUMBUP predicted membrane proteins
   TMHMM predicted membrane proteins
   # TM segments-based
   2TM proteins predicted by MDM
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0005245 [voltage-gated calcium channel activity]
GO:0005886 [plasma membrane]
GO:0006816 [calcium ion transport]
GO:0016021 [integral component of membrane]
GO:0034220 [ion transmembrane transport]
GO:0070588 [calcium ion transmembrane transport]
GO:0086010 [membrane depolarization during action potential]
Show all
 107 aa
12.3 kDa 		No 2
TPCN1-022
ENSP00000446767
ENST00000552542
F8W1L6 [Direct mapping]
Two pore calcium channel protein 1
Show all
Predicted membrane proteins
   Prediction method-based
   Membrane proteins predicted by MDM
   MEMSAT3 predicted membrane proteins
   MEMSAT-SVM predicted membrane proteins
   Phobius predicted membrane proteins
   SCAMPI predicted membrane proteins
   SPOCTOPUS predicted membrane proteins
   THUMBUP predicted membrane proteins
   TMHMM predicted membrane proteins
   # TM segments-based
   2TM proteins predicted by MDM
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0005245 [voltage-gated calcium channel activity]
GO:0005886 [plasma membrane]
GO:0006816 [calcium ion transport]
GO:0016021 [integral component of membrane]
GO:0034220 [ion transmembrane transport]
GO:0070588 [calcium ion transmembrane transport]
GO:0086010 [membrane depolarization during action potential]
Show all
 120 aa
13.7 kDa 		No 2
TPCN1-201
ENSP00000438125
ENST00000541517
Q9ULQ1 [Direct mapping]
Two pore calcium channel protein 1
Show all
Transporters
   Transporter channels and pores
Voltage-gated ion channels
   CatSper and Two-Pore Channels
Predicted membrane proteins
   Prediction method-based
   Membrane proteins predicted by MDM
   MEMSAT3 predicted membrane proteins
   MEMSAT-SVM predicted membrane proteins
   Phobius predicted membrane proteins
   SCAMPI predicted membrane proteins
   SPOCTOPUS predicted membrane proteins
   THUMBUP predicted membrane proteins
   TMHMM predicted membrane proteins
   # TM segments-based
   >9TM proteins predicted by MDM
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0005216 [ion channel activity]
GO:0005245 [voltage-gated calcium channel activity]
GO:0005515 [protein binding]
GO:0005765 [lysosomal membrane]
GO:0005886 [plasma membrane]
GO:0006811 [ion transport]
GO:0006816 [calcium ion transport]
GO:0010008 [endosome membrane]
GO:0016020 [membrane]
GO:0016021 [integral component of membrane]
GO:0034220 [ion transmembrane transport]
GO:0034765 [regulation of ion transmembrane transport]
GO:0042802 [identical protein binding]
GO:0055085 [transmembrane transport]
GO:0070588 [calcium ion transmembrane transport]
GO:0072345 [NAADP-sensitive calcium-release channel activity]
GO:0086010 [membrane depolarization during action potential]
Show all
 888 aa
101.8 kDa 		No >9

Contact

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.