Tissue expression of TPCN1 - Summary - The Human Protein Atlas

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TPCN1

TISSUE

CELL

PATHOLOGY

TISSUE ATLAS PRIMARY DATA

GENE/PROTEIN

Antibody validation

Dictionary


Tissue proteome

GENERAL INFORMATION
Gene name	TPCN1
Gene description	Two pore segment channel 1
Protein class	Predicted intracellular proteins Predicted membrane proteins Transporters Voltage-gated ion channels
Predicted localization	Intracellular,Membrane
Number of transcripts	15
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HUMAN PROTEIN ATLAS INFORMATION

RNA tissue category

HPA:	Expressed in all
GTEx:	Expressed in all
FANTOM5:	Expressed in all

Protein evidence

Evidence at protein level

Protein expression

Cytoplasmic expression in several tissues.

DATA RELIABILITY
Data reliability description	Antibody staining mainly consistent with RNA expression data.
Reliability score	Approved based on 1 antibody. HPA039757
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RNA AND PROTEIN EXPRESSION SUMMARY

RNA expression (TPM)

Protein expression (score)

Brain

Cerebral cortex

Hippocampus

N/A

Caudate

N/A

Cerebellum

N/A

Endocrine tissues

Thyroid gland

Parathyroid gland

Adrenal gland

Bone marrow & immune system

Appendix

Bone marrow

Lymph node

N/A

Tonsil

Spleen

Muscle tissues

Heart muscle

Skeletal muscle

Smooth muscle

Lung

Nasopharynx

N/A

Bronchus

N/A

N/A

Lung

Liver & gallbladder

Liver

Gallbladder

Pancreas

Pancreas

Gastrointestinal tract

Oral mucosa

N/A

Salivary gland

Esophagus

Stomach

Duodenum

Small intestine

Colon

Rectum

Kidney & urinary bladder

Kidney

Urinary bladder

Male tissues

Testis

Epididymis

Prostate

Seminal vesicle

Female tissues

Breast

Vagina

N/A

Cervix, uterine

Endometrium

Fallopian tube

Ovary

Placenta

Adipose & soft tissue

Adipose tissue

Soft tissue

N/A

Skin

Skin

Cerebral cortex

PROTEIN EXPRESSION OVERVIEW
Organ Expression Alphabetical

RNA EXPRESSION OVERVIEW
HPA dataset Organ Expression Alphabetical RNA tissue category: Expressed in all
GTEx dataset Organ Expression Alphabetical RNA tissue category: Expressed in all
FANTOM5 dataset Organ Expression Alphabetical RNA tissue category: Expressed in all

GENE INFORMATION
Gene name	TPCN1 (HGNC Symbol)
Synonyms	FLJ20612, KIAA1169, TPC1
Description	Two pore segment channel 1 (HGNC Symbol)
Entrez gene summary	Voltage-gated Ca(2+) and Na+ channels have 4 homologous domains, each containing 6 transmembrane segments, S1 to S6. TPCN1 is similar to these channels, but it has only 2 domains containing S1 to S6 (Ishibashi et al., 2000 [PubMed 10753632]).[supplied by OMIM, Mar 2008]
Chromosome	12
Cytoband	q24.13
Chromosome location (bp)	113221050 - 113298585
Protein evidence	Evidence at protein level (all genes)
Ensembl	ENSG00000186815 (version 83.38)
Entrez gene	53373
UniProt	Q9ULQ1 (UniProt - Evidence at protein level)
neXtProt	NX_Q9ULQ1
Antibodypedia	TPCN1 antibodies

PROTEIN BROWSER

TPCN1-001	TPCN1-002	TPCN1-003	TPCN1-011	TPCN1-013	TPCN1-014	TPCN1-015	TPCN1-016	TPCN1-017	TPCN1-018	TPCN1-019	TPCN1-020	TPCN1-021	TPCN1-022	TPCN1-201

PROTEIN INFORMATION
Splice variant	UniProt	Protein class	Gene ontology	Length & mass	Signal peptide (predicted)	Transmembrane regions (predicted)
TPCN1-001 ENSP00000335300 ENST00000335509	Q9ULQ1 [Direct mapping] Two pore calcium channel protein 1 Show all	Transporters Transporter channels and pores Voltage-gated ion channels CatSper and Two-Pore Channels Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based >9TM proteins predicted by MDM Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0005216 [ion channel activity] GO:0005245 [voltage-gated calcium channel activity] GO:0005515 [protein binding] GO:0005765 [lysosomal membrane] GO:0005886 [plasma membrane] GO:0006811 [ion transport] GO:0006816 [calcium ion transport] GO:0010008 [endosome membrane] GO:0016020 [membrane] GO:0016021 [integral component of membrane] GO:0034220 [ion transmembrane transport] GO:0034765 [regulation of ion transmembrane transport] GO:0042802 [identical protein binding] GO:0055085 [transmembrane transport] GO:0070588 [calcium ion transmembrane transport] GO:0072345 [NAADP-sensitive calcium-release channel activity] GO:0086010 [membrane depolarization during action potential] Show all	816 aa 94.1 kDa	No	>9
TPCN1-002 ENSP00000448083 ENST00000550785	Q9ULQ1 [Direct mapping] Two pore calcium channel protein 1 Show all	Transporters Transporter channels and pores Voltage-gated ion channels CatSper and Two-Pore Channels Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based >9TM proteins predicted by MDM Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0005216 [ion channel activity] GO:0005245 [voltage-gated calcium channel activity] GO:0005515 [protein binding] GO:0005765 [lysosomal membrane] GO:0005886 [plasma membrane] GO:0006811 [ion transport] GO:0006816 [calcium ion transport] GO:0010008 [endosome membrane] GO:0016020 [membrane] GO:0016021 [integral component of membrane] GO:0034220 [ion transmembrane transport] GO:0034765 [regulation of ion transmembrane transport] GO:0042802 [identical protein binding] GO:0055085 [transmembrane transport] GO:0070588 [calcium ion transmembrane transport] GO:0072345 [NAADP-sensitive calcium-release channel activity] GO:0086010 [membrane depolarization during action potential] Show all	888 aa 101.8 kDa	No	>9
TPCN1-003 ENSP00000376350 ENST00000392569	B7Z3R2 [Direct mapping] Two pore calcium channel protein 1; cDNA FLJ54008, highly similar to Homo sapiens two pore segment channel 1 (TPCN1), mRNA Show all	Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based >9TM proteins predicted by MDM Protein evidence (Ezkurdia et al 2014) Show all	GO:0005216 [ion channel activity] GO:0005245 [voltage-gated calcium channel activity] GO:0005886 [plasma membrane] GO:0006811 [ion transport] GO:0006816 [calcium ion transport] GO:0016020 [membrane] GO:0016021 [integral component of membrane] GO:0034220 [ion transmembrane transport] GO:0034765 [regulation of ion transmembrane transport] GO:0055085 [transmembrane transport] GO:0070588 [calcium ion transmembrane transport] GO:0086010 [membrane depolarization during action potential] Show all	748 aa 87.3 kDa	No	>9
TPCN1-011 ENSP00000449564 ENST00000546781	H0YIK4 [Direct mapping] Two pore calcium channel protein 1 Show all	Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based 2TM proteins predicted by MDM Protein evidence (Ezkurdia et al 2014) Show all	GO:0005216 [ion channel activity] GO:0005245 [voltage-gated calcium channel activity] GO:0005886 [plasma membrane] GO:0006811 [ion transport] GO:0006816 [calcium ion transport] GO:0016020 [membrane] GO:0016021 [integral component of membrane] GO:0034220 [ion transmembrane transport] GO:0034765 [regulation of ion transmembrane transport] GO:0055085 [transmembrane transport] GO:0070588 [calcium ion transmembrane transport] GO:0086010 [membrane depolarization during action potential] Show all	204 aa 23.8 kDa	No	2
TPCN1-013 ENSP00000448561 ENST00000548465	F8VR74 [Direct mapping] Two pore calcium channel protein 1 Show all	Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based 3TM proteins predicted by MDM Protein evidence (Ezkurdia et al 2014) Show all	GO:0005245 [voltage-gated calcium channel activity] GO:0005886 [plasma membrane] GO:0006816 [calcium ion transport] GO:0016021 [integral component of membrane] GO:0034220 [ion transmembrane transport] GO:0070588 [calcium ion transmembrane transport] GO:0086010 [membrane depolarization during action potential] Show all	145 aa 16.7 kDa	No	3
TPCN1-014 ENSP00000448704 ENST00000549279	F8W0K7 [Direct mapping] Two pore calcium channel protein 1 Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0005245 [voltage-gated calcium channel activity] GO:0005886 [plasma membrane] GO:0006816 [calcium ion transport] GO:0034220 [ion transmembrane transport] GO:0070588 [calcium ion transmembrane transport] GO:0086010 [membrane depolarization during action potential] Show all	100 aa 10.7 kDa	No	0
TPCN1-015 ENSP00000449560 ENST00000547275	F8VVY9 [Direct mapping] Two pore calcium channel protein 1 Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0005245 [voltage-gated calcium channel activity] GO:0005886 [plasma membrane] GO:0006816 [calcium ion transport] GO:0034220 [ion transmembrane transport] GO:0070588 [calcium ion transmembrane transport] GO:0086010 [membrane depolarization during action potential] Show all	147 aa 15.7 kDa	No	0
TPCN1-016 ENSP00000447569 ENST00000552985	F8W0P9 [Direct mapping] Two pore calcium channel protein 1 Show all	Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins # TM segments-based 1TM proteins predicted by MDM Protein evidence (Ezkurdia et al 2014) Show all	GO:0005245 [voltage-gated calcium channel activity] GO:0005886 [plasma membrane] GO:0006816 [calcium ion transport] GO:0034220 [ion transmembrane transport] GO:0070588 [calcium ion transmembrane transport] GO:0086010 [membrane depolarization during action potential] Show all	215 aa 22.9 kDa	No	1
TPCN1-017 ENSP00000447806 ENST00000552642	F8VS97 [Direct mapping] Two pore calcium channel protein 1 Show all	Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins # TM segments-based 1TM proteins predicted by MDM Protein evidence (Ezkurdia et al 2014) Show all	GO:0005245 [voltage-gated calcium channel activity] GO:0005886 [plasma membrane] GO:0006816 [calcium ion transport] GO:0034220 [ion transmembrane transport] GO:0070588 [calcium ion transmembrane transport] GO:0086010 [membrane depolarization during action potential] Show all	126 aa 13.7 kDa	No	1
TPCN1-018 ENSP00000447073 ENST00000550873	F8W1G4 [Direct mapping] Two pore calcium channel protein 1 Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0005245 [voltage-gated calcium channel activity] GO:0005886 [plasma membrane] GO:0006816 [calcium ion transport] GO:0034220 [ion transmembrane transport] GO:0070588 [calcium ion transmembrane transport] GO:0086010 [membrane depolarization during action potential] Show all	85 aa 8.8 kDa	No	0
TPCN1-019 ENSP00000447263 ENST00000551096	F8VZZ6 [Direct mapping] Two pore calcium channel protein 1 Show all	SPOCTOPUS predicted secreted proteins Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0005245 [voltage-gated calcium channel activity] GO:0005886 [plasma membrane] GO:0006816 [calcium ion transport] GO:0034220 [ion transmembrane transport] GO:0070588 [calcium ion transmembrane transport] GO:0086010 [membrane depolarization during action potential] Show all	124 aa 12.9 kDa	No	0
TPCN1-020 ENSP00000447181 ENST00000551099	F8W0K7 [Direct mapping] Two pore calcium channel protein 1 Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0005245 [voltage-gated calcium channel activity] GO:0005886 [plasma membrane] GO:0006816 [calcium ion transport] GO:0034220 [ion transmembrane transport] GO:0070588 [calcium ion transmembrane transport] GO:0086010 [membrane depolarization during action potential] Show all	100 aa 10.7 kDa	No	0
TPCN1-021 ENSP00000449944 ENST00000552897	F8VV93 [Direct mapping] Two pore calcium channel protein 1 Show all	Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based 2TM proteins predicted by MDM Protein evidence (Ezkurdia et al 2014) Show all	GO:0005245 [voltage-gated calcium channel activity] GO:0005886 [plasma membrane] GO:0006816 [calcium ion transport] GO:0016021 [integral component of membrane] GO:0034220 [ion transmembrane transport] GO:0070588 [calcium ion transmembrane transport] GO:0086010 [membrane depolarization during action potential] Show all	107 aa 12.3 kDa	No	2
TPCN1-022 ENSP00000446767 ENST00000552542	F8W1L6 [Direct mapping] Two pore calcium channel protein 1 Show all	Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based 2TM proteins predicted by MDM Protein evidence (Ezkurdia et al 2014) Show all	GO:0005245 [voltage-gated calcium channel activity] GO:0005886 [plasma membrane] GO:0006816 [calcium ion transport] GO:0016021 [integral component of membrane] GO:0034220 [ion transmembrane transport] GO:0070588 [calcium ion transmembrane transport] GO:0086010 [membrane depolarization during action potential] Show all	120 aa 13.7 kDa	No	2
TPCN1-201 ENSP00000438125 ENST00000541517	Q9ULQ1 [Direct mapping] Two pore calcium channel protein 1 Show all	Transporters Transporter channels and pores Voltage-gated ion channels CatSper and Two-Pore Channels Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based >9TM proteins predicted by MDM Protein evidence (Ezkurdia et al 2014) Show all	GO:0005216 [ion channel activity] GO:0005245 [voltage-gated calcium channel activity] GO:0005515 [protein binding] GO:0005765 [lysosomal membrane] GO:0005886 [plasma membrane] GO:0006811 [ion transport] GO:0006816 [calcium ion transport] GO:0010008 [endosome membrane] GO:0016020 [membrane] GO:0016021 [integral component of membrane] GO:0034220 [ion transmembrane transport] GO:0034765 [regulation of ion transmembrane transport] GO:0042802 [identical protein binding] GO:0055085 [transmembrane transport] GO:0070588 [calcium ion transmembrane transport] GO:0072345 [NAADP-sensitive calcium-release channel activity] GO:0086010 [membrane depolarization during action potential] Show all	888 aa 101.8 kDa	No	>9

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The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.