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TNFRSF4

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GENERAL INFORMATION

Gene name

 TNFRSF4

Gene description

 Tumor necrosis factor receptor superfamily, member 4

Protein class

 Cancer-related genes
CD markers
Disease related genes
Predicted membrane proteins

Predicted localization

 Membrane

Number of transcripts

 1
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HUMAN PROTEIN ATLAS INFORMATION

Summary

RNA cell category

 Group enriched (NB-4, MOLT-4)

Protein evidence

 Evidence at protein level

Main location

 Not available

DATA RELIABILITY

Reliability score

 Pending cell analysis.

ASSAYS
RNA expression

RNA EXPRESSION OVERVIEW
RNA cell line category: Group enriched (NB-4, MOLT-4)
Organ
Origin
Category
Expression
Alphabetical
Cell lines sorted after organ of phenotypic resemblance.

GENE INFORMATION

Gene name

 TNFRSF4 (HGNC Symbol)

Synonyms

 ACT35, CD134, OX40, TXGP1L

Description

 Tumor necrosis factor receptor superfamily, member 4 (HGNC Symbol)

Entrez gene summary

 The protein encoded by this gene is a member of the TNF-receptor superfamily. This receptor has been shown to activate NF-kappaB through its interaction with adaptor proteins TRAF2 and TRAF5. Knockout studies in mice suggested that this receptor promotes the expression of apoptosis inhibitors BCL2 and BCL2lL1/BCL2-XL, and thus suppresses apoptosis. The knockout studies also suggested the roles of this receptor in CD4+ T cell response, as well as in T cell-dependent B cell proliferation and differentiation. [provided by RefSeq, Jul 2008]

Chromosome

 1

Cytoband

 p36.33

Chromosome location (bp)

 1211326 - 1214138

Protein evidence

 Evidence at protein level (all genes)

Ensembl

 ENSG00000186827 (version 83.38)

Entrez gene

 7293

UniProt

 P43489 (UniProt - Evidence at protein level)

neXtProt

 NX_P43489

Antibodypedia

 TNFRSF4 antibodies

PROTEIN BROWSER
TNFRSF4-001

PROTEIN INFORMATION

Splice variant

UniProt

Protein class

Gene ontology

Length & mass

Signal peptide
(predicted)

Transmembrane regions
(predicted)
TNFRSF4-001
ENSP00000368538
ENST00000379236
P43489 [Direct mapping]
Tumor necrosis factor receptor superfamily member 4
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CD markers
Predicted membrane proteins
   Prediction method-based
   Membrane proteins predicted by MDM
   MEMSAT3 predicted membrane proteins
   MEMSAT-SVM predicted membrane proteins
   Phobius predicted membrane proteins
   SCAMPI predicted membrane proteins
   SPOCTOPUS predicted membrane proteins
   THUMBUP predicted membrane proteins
   TMHMM predicted membrane proteins
   # TM segments-based
   1TM proteins predicted by MDM
Cancer-related genes
   Candidate cancer biomarkers
Disease related genes
Show all
GO:0001618 [virus receptor activity]
GO:0005031 [tumor necrosis factor-activated receptor activity]
GO:0005515 [protein binding]
GO:0005886 [plasma membrane]
GO:0005887 [integral component of plasma membrane]
GO:0006954 [inflammatory response]
GO:0006955 [immune response]
GO:0006968 [cellular defense response]
GO:0007275 [multicellular organismal development]
GO:0009897 [external side of plasma membrane]
GO:0009986 [cell surface]
GO:0030890 [positive regulation of B cell proliferation]
GO:0032496 [response to lipopolysaccharide]
GO:0033209 [tumor necrosis factor-mediated signaling pathway]
GO:0042098 [T cell proliferation]
GO:0042127 [regulation of cell proliferation]
GO:0042981 [regulation of apoptotic process]
GO:0043410 [positive regulation of MAPK cascade]
GO:0043433 [negative regulation of sequence-specific DNA binding transcription factor activity]
GO:0045859 [regulation of protein kinase activity]
GO:0045892 [negative regulation of transcription, DNA-templated]
GO:0046718 [viral entry into host cell]
GO:0050710 [negative regulation of cytokine secretion]
GO:0051024 [positive regulation of immunoglobulin secretion]
GO:0097190 [apoptotic signaling pathway]
Show all
 277 aa
29.3 kDa 		Yes 1

Contact

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.