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A few cases of lymphomas displayed distinct cytoplasmic staining. Remaining cancer cells were negative.
GENE INFORMATION
Gene name
TNFRSF4 (HGNC Symbol)
Synonyms
ACT35, CD134, OX40, TXGP1L
Description
Tumor necrosis factor receptor superfamily, member 4 (HGNC Symbol)
Entrez gene summary
The protein encoded by this gene is a member of the TNF-receptor superfamily. This receptor has been shown to activate NF-kappaB through its interaction with adaptor proteins TRAF2 and TRAF5. Knockout studies in mice suggested that this receptor promotes the expression of apoptosis inhibitors BCL2 and BCL2lL1/BCL2-XL, and thus suppresses apoptosis. The knockout studies also suggested the roles of this receptor in CD4+ T cell response, as well as in T cell-dependent B cell proliferation and differentiation. [provided by RefSeq, Jul 2008]