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KRT14

GENERAL INFORMATION

Gene name

 KRT14

Gene description

 Keratin 14, type I

Protein class

 Cancer-related genes
Disease related genes
Plasma proteins
Predicted intracellular proteins

Predicted localization

 Intracellular

Number of transcripts

 1
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HUMAN PROTEIN ATLAS INFORMATION

RNA category
TCGA (cancer tissue):Group enriched (cervical cancer, head and neck cancer, melanoma)
HPA (cell line):Cell line enhanced (HaCaT, hTCEpi, U-2197)
HPA (normal tissue):Tissue enriched (skin)

Protein evidence

 Evidence at protein level

Protein expression
normal tissue

 Cytoplasmic expression in myoepithelial cells and squamous epithelia.

ANTIBODY IHC RELIABILITY

Data reliability
description

 Antibody staining consistent with RNA expression data. Caution, targets protein from more than one gene.

Reliability score

 Supported based on 3 antibodies.
HPA000452 , HPA023040 , CAB000134
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PROGNOSTIC SUMMARY
Prognostic marker in breast cancer (favourable).
Breast cancer p<0.001
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RNA EXPRESSION OVERVIEW
TCGA dataset
RNA cancer category: Group enriched (cervical cancer, head and neck cancer, melanoma)

PROTEIN EXPRESSION
Colorectal cancer
Breast cancer
Prostate cancer
Lung cancer
Skin cancer

STAINING SUMMARY
HPA000452
HPA023040
CAB000134

GENE INFORMATION

Gene name

 KRT14 (HGNC Symbol)

Synonyms

 EBS3, EBS4

Description

 Keratin 14, type I (HGNC Symbol)

Entrez gene summary

 This gene encodes a member of the keratin family, the most diverse group of intermediate filaments. This gene product, a type I keratin, is usually found as a heterotetramer with two keratin 5 molecules, a type II keratin. Together they form the cytoskeleton of epithelial cells. Mutations in the genes for these keratins are associated with epidermolysis bullosa simplex. At least one pseudogene has been identified at 17p12-p11. [provided by RefSeq, Jul 2008]

Chromosome

 17

Cytoband

 q21.2

Chromosome location (bp)

 41582279 - 41586921

Protein evidence

 Evidence at protein level (all genes)

Ensembl

 ENSG00000186847 (version 83.38)

Entrez gene

 3861

UniProt

 P02533 (UniProt - Evidence at protein level)

neXtProt

 NX_P02533

Antibodypedia

 KRT14 antibodies

PROTEIN BROWSER
KRT14-001

PROTEIN INFORMATION

Splice variant

UniProt

Protein class

Gene ontology

Length & mass

Signal peptide
(predicted)

Transmembrane regions
(predicted)
KRT14-001
ENSP00000167586
ENST00000167586
P02533 [Direct mapping]
Keratin, type I cytoskeletal 14
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Predicted intracellular proteins
Plasma proteins
Cancer-related genes
   Candidate cancer biomarkers
Disease related genes
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
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GO:0005198 [structural molecule activity]
GO:0005200 [structural constituent of cytoskeleton]
GO:0005515 [protein binding]
GO:0005622 [intracellular]
GO:0005634 [nucleus]
GO:0005737 [cytoplasm]
GO:0005829 [cytosol]
GO:0005882 [intermediate filament]
GO:0007568 [aging]
GO:0008544 [epidermis development]
GO:0010043 [response to zinc ion]
GO:0010212 [response to ionizing radiation]
GO:0030855 [epithelial cell differentiation]
GO:0031581 [hemidesmosome assembly]
GO:0034329 [cell junction assembly]
GO:0042633 [hair cycle]
GO:0045095 [keratin filament]
GO:0045110 [intermediate filament bundle assembly]
GO:0070062 [extracellular exosome]
GO:0071944 [cell periphery]
GO:1990254 [keratin filament binding]
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 472 aa
51.6 kDa 		No 0

Contact

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.