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A majority of melanomas as well as several cases of liver, pancreatic, testicular and thyroid cancers. Remaining cancer tissues were in general weakly stained or negative.
GENE INFORMATION
Gene name
POFUT2 (HGNC Symbol)
Synonyms
C21orf80, FUT13, KIAA0958
Description
Protein O-fucosyltransferase 2 (HGNC Symbol)
Entrez gene summary
Fucose is typically found as a terminal modification of branched chain glycoconjugates, but it also exists in direct O-linkage to serine or threonine residues within cystine knot motifs in epidermal growth factor (EGF; MIM 131530)-like repeats or thrombospondin (THBS; see MIM 188060) type-1 repeats. POFUT2 is an O-fucosyltransferase that use THBS type-1 repeats as substrates (Luo et al., 2006 [PubMed 16464857]).[supplied by OMIM, Mar 2008]