Tissue expression of POFUT2 - Summary - The Human Protein Atlas

We use cookies to enhance the usability of our website. If you continue, we'll assume that you are happy to receive all cookies. More information. Don't show this again.

POFUT2

TISSUE

CELL

PATHOLOGY

TISSUE ATLAS PRIMARY DATA

GENE/PROTEIN

Antibody validation

Dictionary


Tissue proteome

GENERAL INFORMATION
Gene name	POFUT2
Gene description	Protein O-fucosyltransferase 2
Protein class	Enzymes Predicted intracellular proteins Predicted secreted proteins
Predicted localization	Intracellular,Secreted
Number of transcripts	5
	SHOW MORE

HUMAN PROTEIN ATLAS INFORMATION

RNA tissue category

HPA:	Expressed in all
GTEx:	Expressed in all
FANTOM5:	Expressed in all

Protein evidence

Evidence at protein level

Protein expression

Estimation of protein expression could not be performed. View primary data.

DATA RELIABILITY
Data reliability description	RNA-based expert annotation gave inconclusive results. Pending external verification.
Reliability score	Uncertain based on 1 antibody. HPA044297
	SHOW MORE

RNA AND PROTEIN EXPRESSION SUMMARY

RNA expression (TPM)

Protein expression (score)

Brain

N/A

Cerebral cortex

N/A

Hippocampus

N/A

N/A

Caudate

N/A

N/A

Cerebellum

N/A

N/A

Endocrine tissues

N/A

Thyroid gland

N/A

Parathyroid gland

N/A

Adrenal gland

N/A

Bone marrow & immune system

N/A

Appendix

N/A

Bone marrow

N/A

Lymph node

N/A

Tonsil

N/A

Spleen

N/A

Muscle tissues

N/A

Heart muscle

N/A

Skeletal muscle

N/A

Smooth muscle

N/A

Lung

N/A

Nasopharynx

N/A

N/A

Bronchus

N/A

N/A

Lung

N/A

Liver & gallbladder

N/A

Liver

N/A

Gallbladder

N/A

Pancreas

N/A

Pancreas

N/A

Gastrointestinal tract

N/A

Oral mucosa

N/A

N/A

Salivary gland

N/A

Esophagus

N/A

Stomach

N/A

Duodenum

N/A

Small intestine

N/A

Colon

N/A

Rectum

N/A

Kidney & urinary bladder

N/A

Kidney

N/A

Urinary bladder

N/A

Male tissues

N/A

Testis

N/A

Epididymis

N/A

Prostate

N/A

Seminal vesicle

N/A

Female tissues

N/A

Breast

N/A

Vagina

N/A

N/A

Cervix, uterine

N/A

Endometrium

N/A

Fallopian tube

N/A

Ovary

N/A

Placenta

N/A

Adipose & soft tissue

N/A

Adipose tissue

N/A

Soft tissue

N/A

N/A

Skin

N/A

Skin

N/A

Cerebral cortex

PROTEIN EXPRESSION OVERVIEW
RNA-based expert annotation could not be performed, due to inconclusive results. View immunohistochemistry primary data.

RNA EXPRESSION OVERVIEW
HPA dataset Organ Expression Alphabetical RNA tissue category: Expressed in all
GTEx dataset Organ Expression Alphabetical RNA tissue category: Expressed in all
FANTOM5 dataset Organ Expression Alphabetical RNA tissue category: Expressed in all

GENE INFORMATION
Gene name	POFUT2 (HGNC Symbol)
Synonyms	C21orf80, FUT13, KIAA0958
Description	Protein O-fucosyltransferase 2 (HGNC Symbol)
Entrez gene summary	Fucose is typically found as a terminal modification of branched chain glycoconjugates, but it also exists in direct O-linkage to serine or threonine residues within cystine knot motifs in epidermal growth factor (EGF; MIM 131530)-like repeats or thrombospondin (THBS; see MIM 188060) type-1 repeats. POFUT2 is an O-fucosyltransferase that use THBS type-1 repeats as substrates (Luo et al., 2006 [PubMed 16464857]).[supplied by OMIM, Mar 2008]
Chromosome	21
Cytoband	q22.3
Chromosome location (bp)	45263928 - 45287898
Protein evidence	Evidence at protein level (all genes)
Ensembl	ENSG00000186866 (version 83.38)
Entrez gene	23275
UniProt	Q9Y2G5 (UniProt - Evidence at protein level)
neXtProt	NX_Q9Y2G5
Antibodypedia	POFUT2 antibodies

PROTEIN BROWSER

POFUT2-001	POFUT2-003	POFUT2-008	POFUT2-201	POFUT2-202

PROTEIN INFORMATION
Splice variant	UniProt	Protein class	Gene ontology	Length & mass	Signal peptide (predicted)	Transmembrane regions (predicted)
POFUT2-001 ENSP00000329682 ENST00000331343	Q9Y2G5 [Direct mapping] GDP-fucose protein O-fucosyltransferase 2 Show all	Enzymes ENZYME proteins Transferases Predicted secreted proteins Secreted proteins predicted by MDSEC SignalP predicted secreted proteins Phobius predicted secreted proteins SPOCTOPUS predicted secreted proteins Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0005789 [endoplasmic reticulum membrane] GO:0005794 [Golgi apparatus] GO:0006004 [fucose metabolic process] GO:0006493 [protein O-linked glycosylation] GO:0036066 [protein O-linked fucosylation] GO:0043687 [post-translational protein modification] GO:0044267 [cellular protein metabolic process] GO:0046922 [peptide-O-fucosyltransferase activity] GO:0051046 [regulation of secretion] Show all	424 aa 48.9 kDa	Yes	0
POFUT2-003 ENSP00000339613 ENST00000349485	Q9Y2G5 [Direct mapping] GDP-fucose protein O-fucosyltransferase 2 Show all	Enzymes ENZYME proteins Transferases Predicted secreted proteins Secreted proteins predicted by MDSEC SignalP predicted secreted proteins Phobius predicted secreted proteins SPOCTOPUS predicted secreted proteins Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0001707 [mesoderm formation] GO:0005789 [endoplasmic reticulum membrane] GO:0005794 [Golgi apparatus] GO:0006004 [fucose metabolic process] GO:0006493 [protein O-linked glycosylation] GO:0008417 [fucosyltransferase activity] GO:0010468 [regulation of gene expression] GO:0010717 [regulation of epithelial to mesenchymal transition] GO:0036065 [fucosylation] GO:0036066 [protein O-linked fucosylation] GO:0043687 [post-translational protein modification] GO:0044267 [cellular protein metabolic process] GO:0046922 [peptide-O-fucosyltransferase activity] GO:0051046 [regulation of secretion] Show all	429 aa 50 kDa	Yes	0
POFUT2-008 ENSP00000407635 ENST00000451615	H7C2T5 [Direct mapping] GDP-fucose protein O-fucosyltransferase 2 Show all	SCAMPI predicted membrane proteins Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all		265 aa 30.3 kDa	No	0
POFUT2-201 ENSP00000478168 ENST00000612472	S6FW71 [Direct mapping] GDP-fucose protein O-fucosyltransferase 2; Protein O-fucosyltransferase 2 Show all	SCAMPI predicted membrane proteins Predicted secreted proteins Secreted proteins predicted by MDSEC SignalP predicted secreted proteins Phobius predicted secreted proteins SPOCTOPUS predicted secreted proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0008152 [metabolic process] GO:0016757 [transferase activity, transferring glycosyl groups] Show all	212 aa 24.4 kDa	Yes	0
POFUT2-202 ENSP00000482216 ENST00000615172	A0A0C4DGX7 [Direct mapping] GDP-fucose protein O-fucosyltransferase 2 Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all		141 aa 16.5 kDa	No	0

Contact

contact@proteinatlas.org

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.