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CYP4A11

GENERAL INFORMATION

Gene name

 CYP4A11

Gene description

 Cytochrome P450, family 4, subfamily A, polypeptide 11

Protein class

 Enzymes
Predicted membrane proteins

Predicted localization

 Membrane

Number of transcripts

 4
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HUMAN PROTEIN ATLAS INFORMATION

RNA category
TCGA (cancer tissue):Tissue enriched (liver cancer)
HPA (cell line):Not detected
HPA (normal tissue):Group enriched (kidney, liver)

Protein evidence

 Evidence at protein level

ANTIBODY IHC RELIABILITY

Reliability score

 Pending cancer tissue analysis.

PROGNOSTIC SUMMARY
Gene product is not prognostic.
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RNA EXPRESSION OVERVIEW
TCGA dataset
RNA cancer category: Tissue enriched (liver cancer)

PROTEIN EXPRESSION

Pending cancer tissue analysis

STAINING SUMMARY

 

GENE INFORMATION

Gene name

 CYP4A11 (HGNC Symbol)

Synonyms

 CYP4A2, CYP4AII

Description

 Cytochrome P450, family 4, subfamily A, polypeptide 11 (HGNC Symbol)

Entrez gene summary

 This gene encodes a member of the cytochrome P450 superfamily of enzymes. The cytochrome P450 proteins are monooxygenases which catalyze many reactions involved in drug metabolism and synthesis of cholesterol, steroids and other lipids. This protein localizes to the endoplasmic reticulum and hydroxylates medium-chain fatty acids such as laurate and myristate. [provided by RefSeq, Jul 2008]

Chromosome

 1

Cytoband

 p33

Chromosome location (bp)

 46929177 - 46941484

Protein evidence

 Evidence at protein level (all genes)

Ensembl

 ENSG00000187048 (version 83.38)

Entrez gene

 1579

UniProt

 Q02928 (UniProt - Evidence at protein level)

neXtProt

 NX_Q02928

Antibodypedia

 CYP4A11 antibodies

PROTEIN BROWSER
CYP4A11-001
CYP4A11-002
CYP4A11-005
CYP4A11-201

PROTEIN INFORMATION

Splice variant

UniProt

Protein class

Gene ontology

Length & mass

Signal peptide
(predicted)

Transmembrane regions
(predicted)
CYP4A11-001
ENSP00000311095
ENST00000310638
Q02928 [Direct mapping]
Cytochrome P450 4A11
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Enzymes
   ENZYME proteins
   Oxidoreductases
Predicted membrane proteins
   Prediction method-based
   Membrane proteins predicted by MDM
   MEMSAT3 predicted membrane proteins
   MEMSAT-SVM predicted membrane proteins
   Phobius predicted membrane proteins
   SCAMPI predicted membrane proteins
   SPOCTOPUS predicted membrane proteins
   THUMBUP predicted membrane proteins
   TMHMM predicted membrane proteins
   # TM segments-based
   1TM proteins predicted by MDM
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
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GO:0001676 [long-chain fatty acid metabolic process]
GO:0003091 [renal water homeostasis]
GO:0003095 [pressure natriuresis]
GO:0005506 [iron ion binding]
GO:0005737 [cytoplasm]
GO:0005789 [endoplasmic reticulum membrane]
GO:0006631 [fatty acid metabolic process]
GO:0006691 [leukotriene metabolic process]
GO:0006805 [xenobiotic metabolic process]
GO:0008392 [arachidonic acid epoxygenase activity]
GO:0016324 [apical plasma membrane]
GO:0016705 [oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen]
GO:0018685 [alkane 1-monooxygenase activity]
GO:0019369 [arachidonic acid metabolic process]
GO:0019373 [epoxygenase P450 pathway]
GO:0020037 [heme binding]
GO:0032305 [positive regulation of icosanoid secretion]
GO:0036101 [leukotriene B4 catabolic process]
GO:0043231 [intracellular membrane-bounded organelle]
GO:0044255 [cellular lipid metabolic process]
GO:0044281 [small molecule metabolic process]
GO:0050051 [leukotriene-B4 20-monooxygenase activity]
GO:0055078 [sodium ion homeostasis]
GO:0055114 [oxidation-reduction process]
GO:0070062 [extracellular exosome]
GO:0097267 [omega-hydroxylase P450 pathway]
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 519 aa
59.3 kDa 		No 1
CYP4A11-002
ENSP00000360972
ENST00000371905
A0A0C4DFV7 [Direct mapping]
Cytochrome P450 4A11
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Predicted membrane proteins
   Prediction method-based
   Membrane proteins predicted by MDM
   MEMSAT3 predicted membrane proteins
   MEMSAT-SVM predicted membrane proteins
   Phobius predicted membrane proteins
   SCAMPI predicted membrane proteins
   SPOCTOPUS predicted membrane proteins
   THUMBUP predicted membrane proteins
   TMHMM predicted membrane proteins
   # TM segments-based
   1TM proteins predicted by MDM
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0004497 [monooxygenase activity]
GO:0005506 [iron ion binding]
GO:0016021 [integral component of membrane]
GO:0016705 [oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen]
GO:0020037 [heme binding]
GO:0055114 [oxidation-reduction process]
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 455 aa
52.1 kDa 		No 1
CYP4A11-005
ENSP00000477495
ENST00000462347
V9GZ77 [Direct mapping]
Cytochrome P450 4A11
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Predicted membrane proteins
   Prediction method-based
   Membrane proteins predicted by MDM
   MEMSAT3 predicted membrane proteins
   MEMSAT-SVM predicted membrane proteins
   Phobius predicted membrane proteins
   SCAMPI predicted membrane proteins
   SPOCTOPUS predicted membrane proteins
   THUMBUP predicted membrane proteins
   TMHMM predicted membrane proteins
   # TM segments-based
   1TM proteins predicted by MDM
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0004497 [monooxygenase activity]
GO:0005506 [iron ion binding]
GO:0016021 [integral component of membrane]
GO:0016705 [oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen]
GO:0020037 [heme binding]
GO:0055114 [oxidation-reduction process]
Show all
 421 aa
47.6 kDa 		No 1
CYP4A11-201
ENSP00000360971
ENST00000371904
E7EVL8 [Direct mapping]
Cytochrome P450 4A11
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Predicted membrane proteins
   Prediction method-based
   Membrane proteins predicted by MDM
   MEMSAT3 predicted membrane proteins
   MEMSAT-SVM predicted membrane proteins
   Phobius predicted membrane proteins
   SCAMPI predicted membrane proteins
   SPOCTOPUS predicted membrane proteins
   THUMBUP predicted membrane proteins
   TMHMM predicted membrane proteins
   # TM segments-based
   1TM proteins predicted by MDM
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0004497 [monooxygenase activity]
GO:0005506 [iron ion binding]
GO:0016021 [integral component of membrane]
GO:0016705 [oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen]
GO:0020037 [heme binding]
GO:0055114 [oxidation-reduction process]
Show all
 520 aa
59.4 kDa 		No 1

Contact

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.