Tissue expression of CYP4A11 - Summary - The Human Protein Atlas

GENERAL INFORMATION
Gene name	CYP4A11
Gene description	Cytochrome P450, family 4, subfamily A, polypeptide 11
Protein class	Enzymes Predicted membrane proteins
Predicted localization	Membrane
Number of transcripts	4
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HUMAN PROTEIN ATLAS INFORMATION

RNA tissue category

HPA:	Group enriched (kidney, liver)
GTEx:	Group enriched (kidney, liver)
FANTOM5:	Group enriched (kidney, liver)

Protein evidence

Evidence at protein level

DATA RELIABILITY
Reliability score	Pending normal tissue annotation.

RNA AND PROTEIN EXPRESSION SUMMARY

RNA expression (TPM)

Protein expression (score)

Brain

N/A

Cerebral cortex

N/A

Hippocampus

N/A

Caudate

N/A

Cerebellum

N/A

Endocrine tissues

N/A

Thyroid gland

N/A

Parathyroid gland

N/A

Adrenal gland

N/A

Bone marrow & immune system

N/A

Appendix

N/A

Bone marrow

N/A

Lymph node

N/A

Tonsil

N/A

Spleen

N/A

Muscle tissues

N/A

Heart muscle

N/A

Skeletal muscle

N/A

Smooth muscle

N/A

Lung

N/A

Nasopharynx

N/A

Bronchus

N/A

Lung

N/A

Liver & gallbladder

N/A

Liver

N/A

Gallbladder

N/A

Pancreas

N/A

Pancreas

N/A

Gastrointestinal tract

N/A

Oral mucosa

N/A

Salivary gland

N/A

Esophagus

N/A

Stomach

N/A

Duodenum

N/A

Small intestine

N/A

Colon

N/A

Rectum

N/A

Kidney & urinary bladder

N/A

Kidney

N/A

Urinary bladder

N/A

Male tissues

N/A

Testis

N/A

Epididymis

N/A

Prostate

N/A

Seminal vesicle

N/A

Female tissues

N/A

Breast

N/A

Vagina

N/A

Cervix, uterine

N/A

Endometrium

N/A

Fallopian tube

N/A

Ovary

N/A

Placenta

N/A

Adipose & soft tissue

N/A

Adipose tissue

N/A

Soft tissue

N/A

Skin

N/A

Skin

N/A

PROTEIN EXPRESSION OVERVIEW
Pending normal tissue annotation.

RNA EXPRESSION OVERVIEW
HPA dataset Organ Expression Alphabetical RNA tissue category: Group enriched (kidney, liver)
GTEx dataset Organ Expression Alphabetical RNA tissue category: Group enriched (kidney, liver)
FANTOM5 dataset Organ Expression Alphabetical RNA tissue category: Group enriched (kidney, liver)

GENE INFORMATION
Gene name	CYP4A11 (HGNC Symbol)
Synonyms	CYP4A2, CYP4AII
Description	Cytochrome P450, family 4, subfamily A, polypeptide 11 (HGNC Symbol)
Entrez gene summary	This gene encodes a member of the cytochrome P450 superfamily of enzymes. The cytochrome P450 proteins are monooxygenases which catalyze many reactions involved in drug metabolism and synthesis of cholesterol, steroids and other lipids. This protein localizes to the endoplasmic reticulum and hydroxylates medium-chain fatty acids such as laurate and myristate. [provided by RefSeq, Jul 2008]
Chromosome	1
Cytoband	p33
Chromosome location (bp)	46929177 - 46941484
Protein evidence	Evidence at protein level (all genes)
Ensembl	ENSG00000187048 (version 83.38)
Entrez gene	1579
UniProt	Q02928 (UniProt - Evidence at protein level)
neXtProt	NX_Q02928
Antibodypedia	CYP4A11 antibodies

PROTEIN BROWSER

CYP4A11-001	CYP4A11-002	CYP4A11-005	CYP4A11-201

PROTEIN INFORMATION
Splice variant	UniProt	Protein class	Gene ontology	Length & mass	Signal peptide (predicted)	Transmembrane regions (predicted)
CYP4A11-001 ENSP00000311095 ENST00000310638	Q02928 [Direct mapping] Cytochrome P450 4A11 Show all	Enzymes ENZYME proteins Oxidoreductases Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based 1TM proteins predicted by MDM Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0001676 [long-chain fatty acid metabolic process] GO:0003091 [renal water homeostasis] GO:0003095 [pressure natriuresis] GO:0005506 [iron ion binding] GO:0005737 [cytoplasm] GO:0005789 [endoplasmic reticulum membrane] GO:0006631 [fatty acid metabolic process] GO:0006691 [leukotriene metabolic process] GO:0006805 [xenobiotic metabolic process] GO:0008392 [arachidonic acid epoxygenase activity] GO:0016324 [apical plasma membrane] GO:0016705 [oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen] GO:0018685 [alkane 1-monooxygenase activity] GO:0019369 [arachidonic acid metabolic process] GO:0019373 [epoxygenase P450 pathway] GO:0020037 [heme binding] GO:0032305 [positive regulation of icosanoid secretion] GO:0036101 [leukotriene B4 catabolic process] GO:0043231 [intracellular membrane-bounded organelle] GO:0044255 [cellular lipid metabolic process] GO:0044281 [small molecule metabolic process] GO:0050051 [leukotriene-B4 20-monooxygenase activity] GO:0055078 [sodium ion homeostasis] GO:0055114 [oxidation-reduction process] GO:0070062 [extracellular exosome] GO:0097267 [omega-hydroxylase P450 pathway] Show all	519 aa 59.3 kDa	No	1
CYP4A11-002 ENSP00000360972 ENST00000371905	A0A0C4DFV7 [Direct mapping] Cytochrome P450 4A11 Show all	Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based 1TM proteins predicted by MDM Protein evidence (Ezkurdia et al 2014) Show all	GO:0004497 [monooxygenase activity] GO:0005506 [iron ion binding] GO:0016021 [integral component of membrane] GO:0016705 [oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen] GO:0020037 [heme binding] GO:0055114 [oxidation-reduction process] Show all	455 aa 52.1 kDa	No	1
CYP4A11-005 ENSP00000477495 ENST00000462347	V9GZ77 [Direct mapping] Cytochrome P450 4A11 Show all	Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based 1TM proteins predicted by MDM Protein evidence (Ezkurdia et al 2014) Show all	GO:0004497 [monooxygenase activity] GO:0005506 [iron ion binding] GO:0016021 [integral component of membrane] GO:0016705 [oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen] GO:0020037 [heme binding] GO:0055114 [oxidation-reduction process] Show all	421 aa 47.6 kDa	No	1
CYP4A11-201 ENSP00000360971 ENST00000371904	E7EVL8 [Direct mapping] Cytochrome P450 4A11 Show all	Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based 1TM proteins predicted by MDM Protein evidence (Ezkurdia et al 2014) Show all	GO:0004497 [monooxygenase activity] GO:0005506 [iron ion binding] GO:0016021 [integral component of membrane] GO:0016705 [oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen] GO:0020037 [heme binding] GO:0055114 [oxidation-reduction process] Show all	520 aa 59.4 kDa	No	1