We use cookies to enhance the usability of our website. If you continue, we'll assume that you are happy to receive all cookies. More information. Don't show this again.
Fields »
 

Field

Term
Gene name

Class

Subclass

Chromosome

External id

In atlas

Reliability

Reliability

Reliability

Validation

Method

Validation

Method

Validation

Method

Validation

Location

Searches

Tissue

Cell type

Expression

Tissue

Specificity

Cell line

Specificity

Cancer

Specificity

Tissue

Detectable

Cell line

Detectable

Cancer

Detectable

Cancer

Prognosis

Category

Score

Score

Score

Antibodies

Column

 
 
ABOUT
HELP
BLOG
  • THE HUMAN PROTEOME
  • THE HUMAN TISSUES
  • THE HUMAN CELL
  • HUMAN PATHOLOGY
  • PROTEIN CLASSES
  • PROTEIN EVIDENCE
    • NEWS
    • BLOG
    • EVENTS
    • PRESS ROOM
    • LEARN
    • DICTIONARY
    • METHODS
    • CELL LINES
  • THE PROJECT
  • INTRODUCTION
  • ORGANIZATION
  • PUBLICATIONS
  • PUBLICATION DATA
  • ANTIBODY SUBMISSION
  • ANTIBODY AVAILABILITY
  • LINKS
  • CONTACT
  • TECHNICAL DATA
  • ANTIBODY VALIDATION
  • ASSAYS & ANNOTATION
  • DISCLAIMER
  • DOWNLOADABLE DATA
  • HELP & FAQ
  • LICENCE & CITATION
  • PRIVACY STATEMENT
  • RELEASE HISTORY
CCK
  • premium

    TISSUE

  • CELL

  • PATHOLOGY

PATHOLOGY ATLAS

GENE/PROTEIN

Antibody validation

Dictionary

Level of antibody staining/expression





High
Medium
Low
Not detected

GENERAL INFORMATION

Gene name

CCK

Gene description

Cholecystokinin

Protein class

Plasma proteins
Predicted secreted proteins

Predicted localization

Secreted

Number of transcripts

3
SHOW MORE

HUMAN PROTEIN ATLAS INFORMATION

RNA category

TCGA (cancer tissue):Group enriched (glioma, pancreatic cancer, prostate cancer, stomach cancer)
HPA (cell line):Group enriched (CAPAN-2, RPTEC TERT1)
HPA (normal tissue):Group enriched (cerebral cortex, duodenum, prostate)

Protein evidence

Evidence at protein level

Protein expression
normal tissue

Cytoplasmic and nuclear expression in several tissues, most abundant in glandular cells of gastrointestinal tract and Purkinje cells.

ANTIBODY IHC RELIABILITY

Data reliability
description

Antibody staining mainly consistent with RNA expression data. Presumed off target binding observed and disregarded.

Reliability score

Supported based on 1 antibody.
CAB002308
SHOW MORE

PROGNOSTIC SUMMARY

Gene product is not prognostic.
Show all

RNA EXPRESSION OVERVIEW

TCGA dataset
RNA cancer category: Group enriched (glioma, pancreatic cancer, prostate cancer, stomach cancer)

PROTEIN EXPRESSION

Colorectal cancer
Breast cancer
Prostate cancer
Lung cancer
Liver cancer

STAINING SUMMARY

CAB002308

Cancer

Cancer staining

Protein
expression of
normal tissue

Breast cancer
 
Carcinoid
 
Cervical cancer
 
 
Colorectal cancer
 
 
Endometrial cancer
 
 
Glioma
 
Head and neck cancer
 
 
Liver cancer
 
 
Lung cancer
 
Lymphoma
 
 
 

Cancer

Cancer staining

Protein
expression of
normal tissue

Melanoma
 
Ovarian cancer
 
Pancreatic cancer
 
Prostate cancer
 
Renal cancer
 
Skin cancer
 
Stomach cancer
 
 
Testis cancer
 
Thyroid cancer
 
Urothelial cancer
 

Staining summary

Cancer tissues showed weak to moderate cytoplasmic immunoreactivity.

GENE INFORMATION

Gene name

CCK

Synonyms

Description

Cholecystokinin (HGNC Symbol)

Entrez gene summary

This gene encodes a member of the gastrin/cholecystokinin family of proteins. The encoded preproprotein is proteolytically processed to generate multiple protein products, including the peptide hormones cholecystokinin-8, -12, -33, and others. The encoded peptides have been shown to regulate gastric acid secretion and food intake. A sulfated form of cholecystokinin-8 may modulate neuronal activity in the brain. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Nov 2015]

Chromosome

3

Cytoband

p22.1

Chromosome location (bp)

42257825 - 42266207

Protein evidence

Evidence at protein level (all genes)

Ensembl

ENSG00000187094 (version 83.38)

Entrez gene

885

UniProt

P06307 (UniProt - Evidence at protein level)

neXtProt

NX_P06307

Antibodypedia

CCK antibodies

PROTEIN BROWSER

CCK-001
CCK-002
CCK-003

PROTEIN INFORMATION

Splice variant

UniProt

Protein class

Gene ontology

Length & mass

Signal peptide
(predicted)

Transmembrane regions
(predicted)

CCK-001
ENSP00000335657
ENST00000334681
P06307 [Direct mapping]
Cholecystokinin Cholecystokinin-58 Cholecystokinin-58 desnonopeptide Cholecystokinin-39 Cholecystokinin-33 Cholecystokinin-25 Cholecystokinin-18 Cholecystokinin-12 Cholecystokinin-8 Cholecystokinin-7 Cholecystokinin-5
Q6FG82 [Target identity:100%; Query identity:100%]
CCK protein; Cholecystokinin; Cholecystokinin, isoform CRA_a; cDNA FLJ76519, highly similar to Homo sapiens cholecystokinin (CCK), mRNA
Show all
Predicted secreted proteins
   Secreted proteins predicted by MDSEC
   SignalP predicted secreted proteins
   Phobius predicted secreted proteins
   SPOCTOPUS predicted secreted proteins
Plasma proteins
Show all
GO:0001764 [neuron migration]
GO:0005179 [hormone activity]
GO:0005184 [neuropeptide hormone activity]
GO:0005515 [protein binding]
GO:0005576 [extracellular region]
GO:0007165 [signal transduction]
GO:0007409 [axonogenesis]
GO:0030424 [axon]
GO:0042755 [eating behavior]
Show all
115 aa
12.7 kDa
Yes 0
CCK-002
ENSP00000379472
ENST00000396169
P06307 [Direct mapping]
Cholecystokinin Cholecystokinin-58 Cholecystokinin-58 desnonopeptide Cholecystokinin-39 Cholecystokinin-33 Cholecystokinin-25 Cholecystokinin-18 Cholecystokinin-12 Cholecystokinin-8 Cholecystokinin-7 Cholecystokinin-5
Q6FG82 [Target identity:100%; Query identity:100%]
CCK protein; Cholecystokinin; Cholecystokinin, isoform CRA_a; cDNA FLJ76519, highly similar to Homo sapiens cholecystokinin (CCK), mRNA
Show all
Predicted secreted proteins
   Secreted proteins predicted by MDSEC
   SignalP predicted secreted proteins
   Phobius predicted secreted proteins
   SPOCTOPUS predicted secreted proteins
Plasma proteins
Protein evidence (Kim et al 2014)
Show all
GO:0001662 [behavioral fear response]
GO:0001764 [neuron migration]
GO:0001836 [release of cytochrome c from mitochondria]
GO:0005179 [hormone activity]
GO:0005184 [neuropeptide hormone activity]
GO:0005515 [protein binding]
GO:0005576 [extracellular region]
GO:0005615 [extracellular space]
GO:0006915 [apoptotic process]
GO:0006919 [activation of cysteine-type endopeptidase activity involved in apoptotic process]
GO:0007165 [signal transduction]
GO:0007205 [protein kinase C-activating G-protein coupled receptor signaling pathway]
GO:0007409 [axonogenesis]
GO:0008284 [positive regulation of cell proliferation]
GO:0014049 [positive regulation of glutamate secretion]
GO:0030424 [axon]
GO:0030425 [dendrite]
GO:0032099 [negative regulation of appetite]
GO:0032461 [positive regulation of protein oligomerization]
GO:0042755 [eating behavior]
GO:0043025 [neuronal cell body]
GO:0043065 [positive regulation of apoptotic process]
GO:0043194 [axon initial segment]
GO:0043195 [terminal bouton]
GO:0043203 [axon hillock]
GO:0043204 [perikaryon]
GO:0050731 [positive regulation of peptidyl-tyrosine phosphorylation]
GO:0051901 [positive regulation of mitochondrial depolarization]
GO:0051930 [regulation of sensory perception of pain]
Show all
115 aa
12.7 kDa
Yes 0
CCK-003
ENSP00000409124
ENST00000434608
P06307 [Direct mapping]
Cholecystokinin Cholecystokinin-58 Cholecystokinin-58 desnonopeptide Cholecystokinin-39 Cholecystokinin-33 Cholecystokinin-25 Cholecystokinin-18 Cholecystokinin-12 Cholecystokinin-8 Cholecystokinin-7 Cholecystokinin-5
Q6FG82 [Target identity:100%; Query identity:100%]
CCK protein; Cholecystokinin; Cholecystokinin, isoform CRA_a; cDNA FLJ76519, highly similar to Homo sapiens cholecystokinin (CCK), mRNA
Show all
Predicted secreted proteins
   Secreted proteins predicted by MDSEC
   SignalP predicted secreted proteins
   Phobius predicted secreted proteins
   SPOCTOPUS predicted secreted proteins
Plasma proteins
Protein evidence (Kim et al 2014)
Show all
GO:0001764 [neuron migration]
GO:0005179 [hormone activity]
GO:0005184 [neuropeptide hormone activity]
GO:0005515 [protein binding]
GO:0005576 [extracellular region]
GO:0007165 [signal transduction]
GO:0007409 [axonogenesis]
GO:0030424 [axon]
GO:0042755 [eating behavior]
Show all
115 aa
12.7 kDa
Yes 0

Contact

  • BLOG
  • PRESS ROOM
  • contact@proteinatlas.org

The Project

  • INTRODUCTION
  • ORGANIZATION
  • PUBLICATIONS
  • DOWNLOADABLE DATA

The Human Protein Atlas

  • ANTIBODY AVAILABILITY
  • LICENCE & CITATION
  • HELP & FAQ
The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.