Expression of FNBP1 in cancer - Summary - The Human Protein Atlas

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FNBP1

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TISSUE

CELL

PATHOLOGY

PATHOLOGY ATLAS

GENE/PROTEIN

Antibody validation

Dictionary


Level of antibody staining/expression
	High Medium Low Not detected

GENERAL INFORMATION
Gene name	FNBP1
Gene description	Formin binding protein 1
Protein class	Cancer-related genes Disease related genes Plasma proteins Predicted intracellular proteins
Predicted localization	Intracellular
Number of transcripts	5
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HUMAN PROTEIN ATLAS INFORMATION

RNA category

TCGA (cancer tissue):	Expressed in all
HPA (cell line):	Mixed
HPA (normal tissue):	Expressed in all

Protein evidence

Evidence at protein level

Protein expression
normal tissue

Cytoplasmic expression most abundant in lymphoid tissues.

ANTIBODY IHC RELIABILITY
Data reliability description	Antibody staining consistent with RNA expression data. Antibody staining in cells/structures not annotated, view images.
Reliability score	Supported based on 2 antibodies. HPA019691 , HPA022119
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PROGNOSTIC SUMMARY
Prognostic marker in renal cancer (unfavourable).
Renal cancer p<0.001 Show all

RNA EXPRESSION OVERVIEW
TCGA dataset RNA cancer category: Expressed in all

PROTEIN EXPRESSION

Colorectal cancer

Prostate cancer

STAINING SUMMARY

HPA019691	HPA022119

GENE INFORMATION
Gene name	FNBP1 (HGNC Symbol)
Synonyms	FBP17, KIAA0554
Description	Formin binding protein 1 (HGNC Symbol)
Entrez gene summary	The protein encoded by this gene is a member of the formin-binding-protein family. The protein contains an N-terminal Fer/Cdc42-interacting protein 4 (CIP4) homology (FCH) domain followed by a coiled-coil domain, a proline-rich motif, a second coiled-coil domain, a Rho family protein-binding domain (RBD), and a C-terminal SH3 domain. This protein binds sorting nexin 2 (SNX2), tankyrase (TNKS), and dynamin; an interaction between this protein and formin has not been demonstrated yet in human. [provided by RefSeq, Jul 2008]
Chromosome	9
Cytoband	q34.11
Chromosome location (bp)	129887187 - 130043194
Protein evidence	Evidence at protein level (all genes)
Ensembl	ENSG00000187239 (version 83.38)
Entrez gene	23048
UniProt	Q96RU3 (UniProt - Evidence at protein level)
neXtProt	NX_Q96RU3
Antibodypedia	FNBP1 antibodies

PROTEIN BROWSER

FNBP1-002	FNBP1-003	FNBP1-004	FNBP1-201	FNBP1-202

PROTEIN INFORMATION
Splice variant	UniProt	Protein class	Gene ontology	Length & mass	Signal peptide (predicted)	Transmembrane regions (predicted)
FNBP1-002 ENSP00000413625 ENST00000446176	Q96RU3 [Direct mapping] Formin-binding protein 1 Show all	Predicted intracellular proteins Plasma proteins Cancer-related genes COSMIC somatic mutations in cancer genes COSMIC Somatic Mutations COSMIC Translocations Disease related genes Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0005515 [protein binding] GO:0005764 [lysosome] GO:0005856 [cytoskeleton] GO:0005886 [plasma membrane] GO:0005905 [coated pit] GO:0005938 [cell cortex] GO:0006897 [endocytosis] GO:0008289 [lipid binding] GO:0016023 [cytoplasmic membrane-bounded vesicle] GO:0042802 [identical protein binding] Show all	617 aa 71.3 kDa	No	0
FNBP1-003 ENSP00000347907 ENST00000355681	Q96RU3 [Direct mapping] Formin-binding protein 1 Show all	Predicted intracellular proteins Plasma proteins Cancer-related genes COSMIC somatic mutations in cancer genes COSMIC Somatic Mutations COSMIC Translocations Disease related genes Protein evidence (Ezkurdia et al 2014) Show all	GO:0005515 [protein binding] GO:0005764 [lysosome] GO:0005856 [cytoskeleton] GO:0005886 [plasma membrane] GO:0005905 [coated pit] GO:0005938 [cell cortex] GO:0006897 [endocytosis] GO:0008289 [lipid binding] GO:0016023 [cytoplasmic membrane-bounded vesicle] GO:0042802 [identical protein binding] Show all	592 aa 68.9 kDa	No	0
FNBP1-004 ENSP00000415602 ENST00000449089	H0Y7W6 [Direct mapping] Formin-binding protein 1 Show all	Predicted intracellular proteins Cancer-related genes COSMIC somatic mutations in cancer genes COSMIC Somatic Mutations COSMIC Translocations Protein evidence (Ezkurdia et al 2014) Show all	GO:0005515 [protein binding] Show all	568 aa 65.2 kDa	No	0
FNBP1-201 ENSP00000407548 ENST00000420781	Q96RU3 [Direct mapping] Formin-binding protein 1 Show all	Predicted intracellular proteins Plasma proteins Cancer-related genes COSMIC somatic mutations in cancer genes COSMIC Somatic Mutations COSMIC Translocations Disease related genes Protein evidence (Ezkurdia et al 2014) Show all	GO:0005515 [protein binding] GO:0005764 [lysosome] GO:0005856 [cytoskeleton] GO:0005886 [plasma membrane] GO:0005905 [coated pit] GO:0005938 [cell cortex] GO:0006897 [endocytosis] GO:0008289 [lipid binding] GO:0016023 [cytoplasmic membrane-bounded vesicle] GO:0042802 [identical protein binding] Show all	612 aa 70.8 kDa	No	0
FNBP1-202 ENSP00000389117 ENST00000443566	B7ZL14 [Direct mapping] FNBP1 protein; Formin-binding protein 1 Show all	Predicted intracellular proteins Cancer-related genes COSMIC somatic mutations in cancer genes COSMIC Somatic Mutations COSMIC Translocations Protein evidence (Ezkurdia et al 2014) Show all	GO:0005515 [protein binding] Show all	551 aa 64.1 kDa	No	0

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The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.