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Term
Gene name

Class

Subclass

Chromosome

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In atlas

Reliability

Reliability

Reliability

Validation

Method

Validation

Method

Validation

Method

Validation

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Searches

Tissue

Cell type

Expression

Tissue

Specificity

Cell line

Specificity

Cancer

Specificity

Tissue

Detectable

Cell line

Detectable

Cancer

Detectable

Cancer

Prognosis

Category

Score

Score

Score

Antibodies

Column

 
 
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FNBP1
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    TISSUE

  • CELL

  • PATHOLOGY

TISSUE ATLAS PRIMARY DATA

GENE/PROTEIN

Antibody validation


Dictionary


Tissue proteome

GENERAL INFORMATION

Gene name

FNBP1

Gene description

Formin binding protein 1

Protein class

Cancer-related genes
Disease related genes
Plasma proteins
Predicted intracellular proteins

Predicted localization

Intracellular

Number of transcripts

5
SHOW MORE

HUMAN PROTEIN ATLAS INFORMATION

RNA tissue category

HPA:Expressed in all
GTEx:Expressed in all
FANTOM5:Expressed in all

Protein evidence

Evidence at protein level

Protein expression

Cytoplasmic expression most abundant in lymphoid tissues.

DATA RELIABILITY

Data reliability
description

Antibody staining consistent with RNA expression data. Antibody staining in cells/structures not annotated, view images.

Reliability score

Supported based on 2 antibodies.
HPA019691 , HPA022119
SHOW MORE

RNA AND PROTEIN EXPRESSION SUMMARY

RNA expression (TPM) Protein expression (score)
Brain
Cerebral cortex
Hippocampus
N/A
Caudate
N/A
Cerebellum
N/A
Endocrine tissues
Thyroid gland
Parathyroid gland
Adrenal gland
Bone marrow & immune system
Appendix
Bone marrow
Lymph node
Tonsil
Spleen
Muscle tissues
Heart muscle
Skeletal muscle
Smooth muscle
Lung
Nasopharynx
N/A
Bronchus
N/A
Lung
Liver & gallbladder
Liver
Gallbladder
Pancreas
Pancreas
Gastrointestinal tract
Oral mucosa
N/A
Salivary gland
Esophagus
Stomach
Duodenum
Small intestine
Colon
Rectum
Kidney & urinary bladder
Kidney
Urinary bladder
Male tissues
Testis
Epididymis
Prostate
Seminal vesicle
Female tissues
Breast
Vagina
N/A
Cervix, uterine
Endometrium
Fallopian tube
Ovary
Placenta
Adipose & soft tissue
Adipose tissue
Soft tissue
N/A
Skin
Skin
Cerebral cortex

Lymph node

Liver

Colon

Kidney

Testis

Prostate

PROTEIN EXPRESSION OVERVIEW

Organ
Expression
Alphabetical

RNA EXPRESSION OVERVIEW

HPA dataset
Organ
Expression
Alphabetical
RNA tissue category: Expressed in all
GTEx dataset
Organ
Expression
Alphabetical
RNA tissue category: Expressed in all
FANTOM5 dataset
Organ
Expression
Alphabetical
RNA tissue category: Expressed in all

GENE INFORMATION

Gene name

FNBP1 (HGNC Symbol)

Synonyms

FBP17, KIAA0554

Description

Formin binding protein 1 (HGNC Symbol)

Entrez gene summary

The protein encoded by this gene is a member of the formin-binding-protein family. The protein contains an N-terminal Fer/Cdc42-interacting protein 4 (CIP4) homology (FCH) domain followed by a coiled-coil domain, a proline-rich motif, a second coiled-coil domain, a Rho family protein-binding domain (RBD), and a C-terminal SH3 domain. This protein binds sorting nexin 2 (SNX2), tankyrase (TNKS), and dynamin; an interaction between this protein and formin has not been demonstrated yet in human. [provided by RefSeq, Jul 2008]

Chromosome

9

Cytoband

q34.11

Chromosome location (bp)

129887187 - 130043194

Protein evidence

Evidence at protein level (all genes)

Ensembl

ENSG00000187239 (version 83.38)

Entrez gene

23048

UniProt

Q96RU3 (UniProt - Evidence at protein level)

neXtProt

NX_Q96RU3

Antibodypedia

FNBP1 antibodies

PROTEIN BROWSER

FNBP1-002
FNBP1-003
FNBP1-004
FNBP1-201
FNBP1-202

PROTEIN INFORMATION

Splice variant

UniProt

Protein class

Gene ontology

Length & mass

Signal peptide
(predicted)

Transmembrane regions
(predicted)

FNBP1-002
ENSP00000413625
ENST00000446176
Q96RU3 [Direct mapping]
Formin-binding protein 1
Show all
Predicted intracellular proteins
Plasma proteins
Cancer-related genes
   COSMIC somatic mutations in cancer genes
   COSMIC Somatic Mutations
   COSMIC Translocations
Disease related genes
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0005515 [protein binding]
GO:0005764 [lysosome]
GO:0005856 [cytoskeleton]
GO:0005886 [plasma membrane]
GO:0005905 [coated pit]
GO:0005938 [cell cortex]
GO:0006897 [endocytosis]
GO:0008289 [lipid binding]
GO:0016023 [cytoplasmic membrane-bounded vesicle]
GO:0042802 [identical protein binding]
Show all
617 aa
71.3 kDa
No 0
FNBP1-003
ENSP00000347907
ENST00000355681
Q96RU3 [Direct mapping]
Formin-binding protein 1
Show all
Predicted intracellular proteins
Plasma proteins
Cancer-related genes
   COSMIC somatic mutations in cancer genes
   COSMIC Somatic Mutations
   COSMIC Translocations
Disease related genes
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0005515 [protein binding]
GO:0005764 [lysosome]
GO:0005856 [cytoskeleton]
GO:0005886 [plasma membrane]
GO:0005905 [coated pit]
GO:0005938 [cell cortex]
GO:0006897 [endocytosis]
GO:0008289 [lipid binding]
GO:0016023 [cytoplasmic membrane-bounded vesicle]
GO:0042802 [identical protein binding]
Show all
592 aa
68.9 kDa
No 0
FNBP1-004
ENSP00000415602
ENST00000449089
H0Y7W6 [Direct mapping]
Formin-binding protein 1
Show all
Predicted intracellular proteins
Cancer-related genes
   COSMIC somatic mutations in cancer genes
   COSMIC Somatic Mutations
   COSMIC Translocations
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0005515 [protein binding]
Show all
568 aa
65.2 kDa
No 0
FNBP1-201
ENSP00000407548
ENST00000420781
Q96RU3 [Direct mapping]
Formin-binding protein 1
Show all
Predicted intracellular proteins
Plasma proteins
Cancer-related genes
   COSMIC somatic mutations in cancer genes
   COSMIC Somatic Mutations
   COSMIC Translocations
Disease related genes
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0005515 [protein binding]
GO:0005764 [lysosome]
GO:0005856 [cytoskeleton]
GO:0005886 [plasma membrane]
GO:0005905 [coated pit]
GO:0005938 [cell cortex]
GO:0006897 [endocytosis]
GO:0008289 [lipid binding]
GO:0016023 [cytoplasmic membrane-bounded vesicle]
GO:0042802 [identical protein binding]
Show all
612 aa
70.8 kDa
No 0
FNBP1-202
ENSP00000389117
ENST00000443566
B7ZL14 [Direct mapping]
FNBP1 protein; Formin-binding protein 1
Show all
Predicted intracellular proteins
Cancer-related genes
   COSMIC somatic mutations in cancer genes
   COSMIC Somatic Mutations
   COSMIC Translocations
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0005515 [protein binding]
Show all
551 aa
64.1 kDa
No 0

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