Expression of LUZP2 in cancer - Summary - The Human Protein Atlas

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LUZP2

TISSUE

CELL

PATHOLOGY

PATHOLOGY ATLAS

GENE/PROTEIN

Antibody validation

Dictionary


Level of antibody staining/expression
	High Medium Low Not detected

GENERAL INFORMATION
Gene name	LUZP2
Gene description	Leucine zipper protein 2
Protein class	Predicted intracellular proteins Predicted secreted proteins
Predicted localization	Intracellular,Secreted
Number of transcripts	4
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HUMAN PROTEIN ATLAS INFORMATION

RNA category

TCGA (cancer tissue):	Group enriched (glioma, prostate cancer)
HPA (cell line):	Cell line enriched (HaCaT)
HPA (normal tissue):	Group enriched (adrenal gland, cerebral cortex)

Protein evidence

Evidence at protein level

Protein expression
normal tissue

Distinct expression in the CNS.

ANTIBODY IHC RELIABILITY
Data reliability description	Antibody staining mainly consistent with RNA expression data. Pending external verification. Presumed off target binding observed and disregarded.
Reliability score	Approved based on 1 antibody. HPA046161
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PROGNOSTIC SUMMARY
Gene product is not prognostic.
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RNA EXPRESSION OVERVIEW
TCGA dataset RNA cancer category: Group enriched (glioma, prostate cancer)

PROTEIN EXPRESSION

Colorectal cancer

Prostate cancer

STAINING SUMMARY

HPA046161

GENE INFORMATION
Gene name	LUZP2
Synonyms
Description	Leucine zipper protein 2 (HGNC Symbol)
Entrez gene summary	This gene encodes a leucine zipper protein. This protein is deleted in some patients with Wilms tumor-Aniridia-Genitourinary anomalies-mental Retardation (WAGR) syndrome. Alternate splicing results in multiple transcript variants. [provided by RefSeq, Oct 2011]
Chromosome	11
Cytoband	p14.3
Chromosome location (bp)	24496970 - 25082631
Protein evidence	Evidence at protein level (all genes)
Ensembl	ENSG00000187398 (version 83.38)
Entrez gene	338645
UniProt	Q86TE4 (UniProt - Evidence at transcript level)
neXtProt	NX_Q86TE4
Antibodypedia	LUZP2 antibodies

PROTEIN BROWSER

LUZP2-001	LUZP2-004	LUZP2-006	LUZP2-201

PROTEIN INFORMATION
Splice variant	UniProt	Protein class	Gene ontology	Length & mass	Signal peptide (predicted)	Transmembrane regions (predicted)
LUZP2-001 ENSP00000432952 ENST00000533227	Q86TE4 [Direct mapping] Leucine zipper protein 2 Show all	Predicted intracellular proteins Protein evidence (Kim et al 2014) Show all	GO:0005576 [extracellular region] Show all	260 aa 28.9 kDa	No	0
LUZP2-004 ENSP00000336817 ENST00000336930	Q86TE4 [Direct mapping] Leucine zipper protein 2 Show all	Predicted secreted proteins Secreted proteins predicted by MDSEC SignalP predicted secreted proteins Phobius predicted secreted proteins SPOCTOPUS predicted secreted proteins Protein evidence (Kim et al 2014) Show all	GO:0005576 [extracellular region] Show all	346 aa 39 kDa	Yes	0
LUZP2-006 ENSP00000437032 ENST00000529015	E9PP05 [Direct mapping] Leucine zipper protein 2 Show all	Predicted secreted proteins Secreted proteins predicted by MDSEC SignalP predicted secreted proteins Phobius predicted secreted proteins SPOCTOPUS predicted secreted proteins Show all		176 aa 20.4 kDa	Yes	0
LUZP2-201 ENSP00000480441 ENST00000620308	Q86TE4 [Direct mapping] Leucine zipper protein 2 Show all	Predicted intracellular proteins Show all	GO:0005576 [extracellular region] Show all	260 aa 28.9 kDa	No	0

Contact

contact@proteinatlas.org

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.