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LUZP2

GENERAL INFORMATION

Gene name

 LUZP2

Gene description

 Leucine zipper protein 2

Protein class

 Predicted intracellular proteins
Predicted secreted proteins

Predicted localization

 Intracellular,Secreted

Number of transcripts

 4
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HUMAN PROTEIN ATLAS INFORMATION

RNA tissue category
HPA:Group enriched (adrenal gland, cerebral cortex)
GTEx:Group enriched (adrenal gland, caudate, cerebral cortex, hippocampus, hypothalamus)
FANTOM5:Group enriched (brain, caudate, cerebellum, hippocampus, pituitary gland)

Protein evidence

 Evidence at protein level

Protein expression

 Distinct expression in the CNS.

DATA RELIABILITY

Data reliability
description

 Antibody staining mainly consistent with RNA expression data. Pending external verification. Presumed off target binding observed and disregarded.

Reliability score

 Approved based on 1 antibody.
HPA046161
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RNA AND PROTEIN EXPRESSION SUMMARY
RNA expression (TPM) Protein expression (score)
Brain
Caudate
N/A
Endocrine tissues
Bone marrow & immune system
Muscle tissues
Lung
Bronchus
N/A
Liver & gallbladder
Pancreas
Gastrointestinal tract
Kidney & urinary bladder
Male tissues
Female tissues
Vagina
N/A
Adipose & soft tissue
Skin
Cerebral cortex

Cerebellum

Lymph node

Liver

Colon

Kidney

Testis

PROTEIN EXPRESSION OVERVIEW
Organ
Expression
Alphabetical

RNA EXPRESSION OVERVIEW
HPA dataset
Organ
Expression
Alphabetical
RNA tissue category: Group enriched (adrenal gland, cerebral cortex)
GTEx dataset
Organ
Expression
Alphabetical
RNA tissue category: Group enriched (adrenal gland, caudate, cerebral cortex, hippocampus, hypothalamus)
FANTOM5 dataset
Organ
Expression
Alphabetical
RNA tissue category: Group enriched (brain, caudate, cerebellum, hippocampus, pituitary gland)

GENE INFORMATION

Gene name

 LUZP2

Synonyms

Description

 Leucine zipper protein 2 (HGNC Symbol)

Entrez gene summary

 This gene encodes a leucine zipper protein. This protein is deleted in some patients with Wilms tumor-Aniridia-Genitourinary anomalies-mental Retardation (WAGR) syndrome. Alternate splicing results in multiple transcript variants. [provided by RefSeq, Oct 2011]

Chromosome

 11

Cytoband

 p14.3

Chromosome location (bp)

 24496970 - 25082631

Protein evidence

 Evidence at protein level (all genes)

Ensembl

 ENSG00000187398 (version 83.38)

Entrez gene

 338645

UniProt

 Q86TE4 (UniProt - Evidence at transcript level)

neXtProt

 NX_Q86TE4

Antibodypedia

 LUZP2 antibodies

PROTEIN BROWSER
LUZP2-001
LUZP2-004
LUZP2-006
LUZP2-201

PROTEIN INFORMATION

Splice variant

UniProt

Protein class

Gene ontology

Length & mass

Signal peptide
(predicted)

Transmembrane regions
(predicted)
LUZP2-001
ENSP00000432952
ENST00000533227
Q86TE4 [Direct mapping]
Leucine zipper protein 2
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Predicted intracellular proteins
Protein evidence (Kim et al 2014)
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GO:0005576 [extracellular region]
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 260 aa
28.9 kDa 		No 0
LUZP2-004
ENSP00000336817
ENST00000336930
Q86TE4 [Direct mapping]
Leucine zipper protein 2
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Predicted secreted proteins
   Secreted proteins predicted by MDSEC
   SignalP predicted secreted proteins
   Phobius predicted secreted proteins
   SPOCTOPUS predicted secreted proteins
Protein evidence (Kim et al 2014)
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GO:0005576 [extracellular region]
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 346 aa
39 kDa 		Yes 0
LUZP2-006
ENSP00000437032
ENST00000529015
E9PP05 [Direct mapping]
Leucine zipper protein 2
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Predicted secreted proteins
   Secreted proteins predicted by MDSEC
   SignalP predicted secreted proteins
   Phobius predicted secreted proteins
   SPOCTOPUS predicted secreted proteins
Show all
 176 aa
20.4 kDa 		Yes 0
LUZP2-201
ENSP00000480441
ENST00000620308
Q86TE4 [Direct mapping]
Leucine zipper protein 2
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Predicted intracellular proteins
Show all
GO:0005576 [extracellular region]
Show all
 260 aa
28.9 kDa 		No 0

Contact

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.