Expression of TMEM72 in cancer - Summary - The Human Protein Atlas

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TMEM72

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TISSUE

CELL

PATHOLOGY

PATHOLOGY ATLAS

GENE/PROTEIN

Antibody validation

Dictionary


Level of antibody staining/expression
	High Medium Low Not detected

GENERAL INFORMATION
Gene name	TMEM72
Gene description	Transmembrane protein 72
Protein class	Predicted intracellular proteins Predicted membrane proteins
Predicted localization	Intracellular,Membrane
Number of transcripts	2
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HUMAN PROTEIN ATLAS INFORMATION

RNA category

TCGA (cancer tissue):	Tissue enriched (renal cancer)
HPA (cell line):	Group enriched (RPMI-8226, U-937)
HPA (normal tissue):	Tissue enriched (kidney)

Protein evidence

Evidence at protein level

Protein expression
normal tissue

Distinct cytoplasmic expression in distal renal tubules.

ANTIBODY IHC RELIABILITY
Data reliability description	Antibody staining consistent with RNA expression data. Pending external verification.
Reliability score	Supported based on 2 antibodies. HPA039894 , HPA062907
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PROGNOSTIC SUMMARY
Prognostic marker in renal cancer (favourable).
Renal cancer p<0.001 Show all

RNA EXPRESSION OVERVIEW
TCGA dataset RNA cancer category: Tissue enriched (renal cancer)

PROTEIN EXPRESSION

Colorectal cancer

Prostate cancer

STAINING SUMMARY

HPA039894	HPA062907

GENE INFORMATION
Gene name	TMEM72 (HGNC Symbol)
Synonyms	bA285G1.3, C10orf127, KSP37
Description	Transmembrane protein 72 (HGNC Symbol)
Entrez gene summary
Chromosome	10
Cytoband	q11.21
Chromosome location (bp)	44911200 - 44937002
Protein evidence	Evidence at protein level (all genes)
Ensembl	ENSG00000187783 (version 83.38)
Entrez gene	643236
UniProt	A0PK05 (UniProt - Evidence at transcript level)
neXtProt	NX_A0PK05
Antibodypedia	TMEM72 antibodies

PROTEIN BROWSER

TMEM72-001	TMEM72-201

PROTEIN INFORMATION
Splice variant	UniProt	Protein class	Gene ontology	Length & mass	Signal peptide (predicted)	Transmembrane regions (predicted)
TMEM72-001 ENSP00000374234 ENST00000389583	A0PK05 [Direct mapping] Transmembrane protein 72 Show all	Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based 3TM proteins predicted by MDM Show all	GO:0016021 [integral component of membrane] Show all	275 aa 29.9 kDa	No	3
TMEM72-201 ENSP00000439911 ENST00000544540	A0PK05 [Direct mapping] Transmembrane protein 72 Show all	Predicted intracellular proteins Show all	GO:0016021 [integral component of membrane] Show all	157 aa 16.9 kDa	No	0

Contact

contact@proteinatlas.org

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.